Solid-state compounding of immiscible PCL-PEO blend powders for molding processes

Allaf, Rula M.; Albarahmieh, Esra’a; Alhamarneh, Baider

doi:10.1016/j.jmbbm.2019.05.023

Cited by 8 publications

(8 citation statements)

References 65 publications

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“…Then, XRD results (Figure 6a) showed that PCL had a high narrow diffraction peak at 21 • , and there was a lower diffraction peak at 24 • . It was a typical XRD result of PCL, which was similar to the results from other researches [37,38]. PECL was also observed to have these two diffraction peaks, but the strength is significantly reduced, indicating that the presence of the PEG block was not conducive to crystallization.…”

Section: Characterization Of Pcl Porous Microspheressupporting

confidence: 86%

Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics

Shi

Zhang

et al. 2022

Polymers

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Polymer porous microspheres with large specific surface areas and good fluidity have promising important applications in the biomedical field. However, controllable fabrication of porous microspheres with precise size, morphology, and pore structure is still a challenge, and phase separation caused by the instability of the emulsion is the main factor affecting the precise preparation of porous microspheres. Herein, a method combining the iso-density emulsion (IDE) template and microfluidics was proposed to realize the controllable preparation of polymer porous microspheres. The IDE exhibited excellent stability with minimal phase separation within 4 h, thus showing potential advantages in the large-scale preparation of porous microspheres. With the IDE template combined microfluidics technique and the use of a customized amphoteric copolymer, PEG-b-polycaprolactone, polycaprolactone (PCL) porous microspheres with porosity higher than 90% were successfully prepared. Afterwards, the main factors, including polymer concentration, water–oil ratio and homogenization time were investigated to regulate the pore structure of microspheres, and microspheres with different pore sizes (1–30 μm) were obtained. PCL porous microspheres exhibited comparable cell viability relative to the control group and good potential as cell microcarriers after surface modification with polydopamine. The modified PCL porous microspheres implanted subcutaneously in rats underwent rapid in vivo degradation and tissue ingrowth. Overall, this study demonstrated an efficient strategy for the precise preparation of porous microspheres and investigated the potential of the as-prepared PCL porous microspheres as cell microcarriers and micro-scaffolds.

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Section: Characterization Of Pcl Porous Microspheressupporting

confidence: 86%

Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics

Shi

Zhang

et al. 2022

Polymers

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“…DSC analyses of the moulded solid dispersions 1, 2, and 3 revealed a single melting peak corresponding to the crystalline fraction of PEO at temperatures of 67 °C in T onset 58 °C (Δ H m = 137 J g −1 ), 67 °C in T onset 57 °C (Δ H m = 107 J g −1 ), and 65 °C in T onset 56 °C (Δ H m = 72 J g −1 ), respectively. As the fraction of PCL increased from 35% to 45% inside the formulations, it was possible to identify a small “shoulder” besides the PEO melting peak due to their immiscibility [ 26 , 44 ]. The decrease in the heat of fusion amount was already indicative of the crystallinity change within the system.…”

Section: Resultsmentioning

confidence: 99%

“…After analysing the diffractogram of each polymer before and after the melt processing techniques, PEO’s main diffraction peaks at 19.09 and 23.24° [ 52 ] reduced expressively, followed by PCL diffraction peaks at 21.53 and 23.76° [ 53 ] almost disappearing, but the diffraction peak at 21.53° improved slightly due to the increase in PCL inside the formulations from 35 to 45%. The literature reports that PEO/PCL-blend–based matrices usually display convoluted peaks with intensities dependent on the blend composition [ 26 ]. Thus, these data endorse our thermal studies.…”

Section: Resultsmentioning

confidence: 99%

Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazole

Bezerra¹,

Lima

Colbert³

et al. 2023

Pharmaceutics

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Fenbendazole (FBZ) is a broad-spectrum anthelmintic administered orally to ruminants; nevertheless, its poor water solubility has been the main limitation to reaching satisfactory and sustained levels at the site of the target parasites. Hence, the exploitation of hot-melt extrusion (HME) and micro-injection moulding (µIM) for the manufacturing of extended-release tablets of plasticised solid dispersions of poly(ethylene oxide) (PEO)/polycaprolactone (PCL) and FBZ was investigated due to their unique suitability for semi-continuous manufacturing of pharmaceutical oral solid dosage forms. High-performance liquid chromatography (HPLC) analysis demonstrated a consistent and uniform drug content in the tablets. Thermal analysis using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) suggested the amorphous state of the active ingredient, which was endorsed by powder X-ray diffraction spectroscopy (pXRD). Fourier transform infrared spectroscopy (FTIR) analysis did not display any new peak indicative of either a chemical interaction or degradation. Scanning electron microscopy (SEM) images showed smoother surfaces and broader pores as we increased the PCL content. Electron-dispersive X-ray spectroscopy (EDX) revealed that the drug was homogeneously distributed within the polymeric matrices. Drug release studies attested that all moulded tablets of amorphous solid dispersions improved the drug solubility, with the PEO/PCL blend–based matrices showing drug release by Korsmeyer–Peppas kinetics. Thus, HME coupled with µIM proved to be a promising approach towards a continuous automated manufacturing process for the production of oral solid dispersions of benzimidazole anthelmintics to grazing cattle.

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“…The test results show that the heat treatment is not pertinent to the crystal formation of the blends. The diffraction peak of PCL appears at 2θ: 21.4°and 23.8° [25,26], and the diffraction peaks of PEG appear at 2θ: 19.2°and 23.3° [27]. PVA-PCL/PEG stents do not show other crystal formations after heat treatment, indicating that materials are immiscible [28].…”

Section: Mechanical Properties Of Tissue Engineering Stentsmentioning

confidence: 94%

Tissue engineering stent model with long fiber-reinforced thermoplastic technique

Lin

Huang

et al. 2020

J Mater Sci: Mater Med

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This study aims to construct tissue engineering stents by using the long fiber-reinforced thermoplastic (LFT) technique to develop artery stents. The experimental method combines fibers, the LFT technique, and electrospinning technique. First, the biodegradable polyvinyl alcohol yarns are twisted and coated in polycaprolactone/polyethylene glycol blends through the LFT technique. Next, the weft-knitting and heat treatment are used to establish the stent structure, after which poly (ethylene oxide) (PEO) is electrospun to coat the stents. The morphology, mechanical, and biological properties of tissue engineering stents are evaluated. The test results indicated that the use of the LFT technique retains the softness of filaments, which facilitates the subsequent weft-knitting process. The coating of blends and electrospinning of PEO have a positive influence on the tissue engineering stents, as demonstrated by the tensile strength of 59.93 N and compressive strength of 6.10 N. Moreover, the in vitro degradation of stents exhibits a stabilized process. The water contact angle is 20.33°, and the cell survival rate in 24 h is over 80%. The proposed tissue engineering stents are good candidates for artery stent structure.

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Solid-state compounding of immiscible PCL-PEO blend powders for molding processes

Cited by 8 publications

References 65 publications

Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics

Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics

Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazole

Tissue engineering stent model with long fiber-reinforced thermoplastic technique

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