Solid state characterization of domperidone: Hydroxypropyl-b-cyclodextrin inclusion complex

Abstract

The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a function of hydroxylpropyl-β-cyclodextrin concentration, showing AL type diagram. Solid domperidone/hydroxylpropyl-β-cyclodextrin complex was prepared in ratio 1:1 by ultrasonication and kneading method. Solid state inclusion complex was characterized by FTIR, powder X-ray diffraction and differential-scanning calorimetry techniques. FTIR studies showed intactness of drug in complex whereas powder diffraction studies showed that hydroxylpropyl-β-cyclodextrin complex was amorphous. Solubility studies showed that complexation increased domperidone solubility as compared to pure drug in 0.1M hydrochloric acid and distilled water. Drug content confirms that ultrasonication is one of the efficient methods to prepare inclusion complex. Dissolution data of inclusion complexes also indicated that there is 1.4 folds increase in dissolution as compared to pure drug and was observed in case of inclusion complexes prepared by ultrasonication.

Solubility Enhancement of Domperidone by Solvent Change In situ Micronization Technique

“…Similar findings were reported in preparing the inclusion complex of DOM-hydroxypropyl-β-cyclodextrin[ 31 ] and DOM hydrogels. [ 21 ]…”

Preparation and characterization of domperidone nanoparticles for dissolution improvement

“…Domperidone exhibited a strong characteristic absorbance band at 1714 cm -1 due to C = O stretching vibrations of amide functional group CONHR, and N ̶ H bending characteristic band at 1693 cm -1 , N ̶ H stretching band of secondary amine appeared at 3126 cm -1 as a single band, symmetric and asymmetric C ̶ H stretching bands appeared at 2810 and 2941 cm -1 respectively. As well as aromatic symmetric and asymmetric C ̶ H stretching bands appeared at 3024 and 3074 cm -1 respectively, and the aromatic C = C stretching band appeared at 1624 cm -1 (22) as shown in figure (12). The resulted FTIR of PVP-K15, the physical mixtures of PVP-K15:pure domperidone (2:1) and F8 as in figures (13, 14 and 15) showed the presence of main peaks of domperidone which indicates there is no interaction or complexation between drug and polymer during preparation of nanoparticles.…”

Spectroscopic Investigations for Photo Stability of Diclofenac Sodium Complexed with Hydroxypropyl-beta-Cyclodextrin

“…Fourier Transform Infrared Spectroscopy (FTIR) experiments were carried out in Shimadzu, IR Affinity-1 spectrometer in a range from 400 to 4000 cm -1 with 2 cm -1 resolution. DS, HPβCD, physical mixtures and the inclusion complexes were analyzed using KBr pellets (Ghodke et al, 2010). UV-Visible Analysis were carried out in a Jasco, V-670 spectrometer at 276nm in a range of 200-400nm for DS and at 282nm in a range of 250-350nm for HPβCD.…”