Preparation and characterization of domperidone nanoparticles for dissolution improvement

Al-lami, Mohammed S.; Oudah, Malath H.; Rahi, Firas Aziz

doi:10.31351/vol27iss1pp39-52

Cited by 3 publications

(2 citation statements)

References 11 publications

(14 reference statements)

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“…This top-down approach allows for easy scalability, enabling the production of large batches of NC while avoiding the use of organic solvents. Other authors have also investigated various methods for producing DOM-NC, including supercritical antisolvent precipitation and a combination of solvent evaporation and sonication [ 31 , 32 ]. Although these techniques have shown potential in improving the properties of DOM, they may not be as practical for industrial-scale production due to various limitations.…”

Section: Resultsmentioning

confidence: 99%

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

et al. 2023

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Domperidone (DOM) is a drug commonly used to treat nausea and vomiting, as well as gastrointestinal disorders. However, its low solubility and extensive metabolism pose significant administration challenges. In this study, we aimed to improve DOM solubility and avoid its metabolism by developing nanocrystals (NC) of DOM through a 3D printing technology—melting solidification printing process (MESO-PP)—to be delivered via a solid dosage form (SDF) that can be administered sublingually. We obtained DOM-NCs using the wet milling process and designed an ultra-rapid release ink (composed of PEG 1500, propylene glycol, sodium starch glycolate, croscarmellose sodium, and sodium citrate) for the 3D printing process. The results demonstrated an increase in the saturation solubility of DOM in both water and simulated saliva without any physicochemical changes in the ink as observed by DSC, TGA, DRX, and FT-IR. The combination of nanotechnology and 3D printing technology enabled us to produce a rapidly disintegrating SDF with an improved drug-release profile. This study demonstrates the potential of developing sublingual dosage forms for drugs with low aqueous solubility using nanotechnology and 3D printing technology, providing a feasible solution to the challenges associated with the administration of drugs with low solubility and extensive metabolism in pharmacology.

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Section: Resultsmentioning

confidence: 99%

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

et al. 2023

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“…In general, it is recommended that a second consecutive process has to be performed for particle preservation that is spraydrying or lyophilisation (5) . Cilnidipine was dissolved in a methanol (solvent) 5 ml at room temperature; organic solution was dropped slowly by means of a syringe onto 50 ml of DW (antisolvent) containing surfactant and subsequently stirred at agitation speed of about 1000 round per minute (rpm) on magnetic stirrer for 1 hour to allow the volatile solvent (methanol)to evaporate (6) . Pharmaceutical applications have been reported for nanoparticle engineering methods that accelerate drug solubility and dissolution rates (7) .…”

Section: Introductionmentioning

confidence: 99%

Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate

A. Al Hazzaa,

Rajab

2023

IJPS

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Cilnidipine CLD fourth generation Ca+2 channel blockers, since cilnidipine has a very low solubility (BCS Class-II drug Low solubility High permeability) and extremely low medication compliance, it has been used to treat hypertension and hypertensive-associated vascular disorders.so cilnidipine can be formulated as nanocrystals NCs using solvent anti-solvent technology which can improve the solubility and bioavailability .Two different stabilizers(poloxamer 188 and Tween20) were utilized to prepare nine formula with different ratio 1:0.25,1:0.5 and 1:1. Study and evaluation the formulation factors which may effect on particle size and Polydispersity index PDI. The prepared CLD NCs were evaluated for particle size and dissolution study ,F4 was the smallest size 152 nm ,PDI (0.161 )and the saturated solubility was increased about ten folds, this formula was subjected for freeze drying by adding 3 % mannitol as cryoprotectant .A complete dissolusion was established in about 20 minutes which confer the DSC and PXRD results in conversion from crystalline into amorphous state .It can conclude that solvent anti-solvent technique was a useful in preparation of nanocrystals suspension .

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Formulation and Evaluation of Ondansetron HCl Nanoparticles for Transdermal Delivery

Noor

Ghareeb²

2020

IJPS

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Ondansetron HCl (OND) is a potent antiemetic drug used for control of nausea and vomiting associated with cancer chemotherapy. It exhibits only 60 – 70 % of oral bioavailability due to first pass metabolism and has a relative short half-life of 3-5 hours. Poor bioavailability not only leads to the frequent dosing but also shows very poor patient adherence. Hence, in the present study an approach has been made to develop OND nanoparticles using eudragit® RS100 and eudragit® RL100 polymer to control release of OND for transdermal delivery and to improve patient compliance. Six formulas of OND nanoparticles were prepared using nanoprecipitation technique. The particles sizes and zeta potential were measured using zeta-plus analyzer. The particle morphology was also studied using scanning electron microscopy (SEM). The in-vitro release of the drug from the nanoparticles was carried out in phosphate buffer saline pH 7.4. The particle size of the prepared NPs were in nano size which ranged from (95.34 to 275.84 nm) with positive zeta potential. The drug entrapment efficiency was varied with the drug polymer ratio from 41.87% to 78.45%. The SEM showed uniform shape and regularly distributed particle sizes. The in-vitro drug release study exhibited the sustained release of OND with burst release. The cumulative percentage released after 12 hr. were between were 77.89 and 96.01%. Also the transdermal permeation study show that nanoparticles permeate more efficiently than aqueous solution of the drug through the skin by approximately two fold. OND nanoparticles were prepared successfully using nanoprecipitation method. The controlled drug release aimed for transdermal drug delivery could be obtained by using eudragit RS100 and eudragit RL100 polymers which can reduce dosing frequency, decrease side effects and improve patient compliance.

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Preparation and characterization of domperidone nanoparticles for dissolution improvement

Cited by 3 publications

References 11 publications

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate

Formulation and Evaluation of Ondansetron HCl Nanoparticles for Transdermal Delivery

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