Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate
Suray A. Al Hazzaa,
Nawal A. Rajab
Abstract:Cilnidipine CLD fourth generation Ca+2 channel blockers, since cilnidipine has a very low solubility (BCS Class-II drug Low solubility High permeability) and extremely low medication compliance, it has been used to treat hypertension and hypertensive-associated vascular disorders.so cilnidipine can be formulated as nanocrystals NCs using solvent anti-solvent technology which can improve the solubility and bioavailability .Two different stabilizers(poloxamer 188 and Tween20) were utilized to prepare nine form… Show more
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