Solid Pseudopapillary Tumor of the Pancreas: A Single-center Experience and Review of the Literature

Antoniou, Efstathios; Damaskos, Christos; Garmpis, Nikolaos; Salakos, Christos; Margonis, Georgios Antonios; Kontzoglou, Konstantinos; Lahanis, Stefanos; Spartalis, Eleftherios; Patsouras, Dimitrios; Kykalos, Stylianos; Garmpi, Anna; Andreatos, Nikolaos; Pawlik, Timothy M.; Kouraklis, Gregory

doi:10.21873/invivo.11089

Cited by 27 publications

(28 citation statements)

References 36 publications

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“…Liver metastases (n=2) were identified after 1 year and then 5 years after resection; 5- and 10-year disease-free survival rate was 96.5% and 89.6% respectively [ 10 ]. Similarly, Antoniou et al described 5 cases of females with Franz tumor treated with radical pancreatectomy who continue to be under observation and do not present with symptoms of locally recurrent disease [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Liver Transplantation for a Metastatic Pancreatic Solid-Pseudopapillary Tumor (Frantz Tumor): A Case Report

et al. 2018

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BackgroundSolid-pseudopapillary neoplasms (SPN) of the pancreas, first described by Frantz in 1959, are a very rare entity and account for 0.13–2.7% of all pancreatic neoplasms. They are seen predominantly in young women in their second and third decade of life.Case ReportWe report a case of a 51-year-old female first diagnosed with a pancreatic tumor in 2010 following a computed tomography (CT) scan of the abdomen. The lesion was originally thought to be a neuroendocrine tumor subsequently treated with chemotherapy, which delayed the appropriate treatment. The tumor was rediagnosed as a SPN only after pancreatectomy was performed. Due to the fact that the neoplasm metastasized to the liver, the patient underwent an orthotopic cadaveric liver transplantation (OLTx) in 2013. During the postoperative period lymph node metastases were identified in the abdomen. The patient received surgical treatment and palliative radiotherapy. Presently no signs of recurrence are found either in the bed of pancreatic resection or in the transplanted liver. The function of the transplant organ has demonstrated no abnormalities over the 4-year follow-up.ConclusionsSPN of the pancreas is a rare disease associated with heterogeneous clinical course ranging from benign to metastatic. Choosing appropriate treatment requires individual clinical assessment of the disease’s spread. Partial living donor liver transplantation or cadaveric liver transplantation might prove an effective therapeutic option for patients with multiple SPN metastases in the liver. It ought to be remembered, however, that the experience in this area is quite limited.

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Section: Discussionmentioning

confidence: 99%

Liver Transplantation for a Metastatic Pancreatic Solid-Pseudopapillary Tumor (Frantz Tumor): A Case Report

et al. 2018

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“…These were previously referred to using a variety of descriptive and eponymous names, before official nomenclature was proposed by the World Health Organization in 1996 and its classification as a borderline malignant tumor of the exocrine pancreas 4567. Over the past two decades, there has been an increasing frequency of cases of these tumors diagnosed and reported in the literature partly due to the widespread use of cross sectional imaging and better knowledge of the condition 78. SPPN have been well characterized as a tumor predominantly seen in young females in the second and third decades of life 123789.…”

Section: Introductionmentioning

confidence: 99%

“…Over the past two decades, there has been an increasing frequency of cases of these tumors diagnosed and reported in the literature partly due to the widespread use of cross sectional imaging and better knowledge of the condition 78. SPPN have been well characterized as a tumor predominantly seen in young females in the second and third decades of life 123789. Surgical resection is routinely indicated due to its frequency of symptomatic presentations and substantial risk of metastatic progression described in up to 15% of cases 79101112…”

Section: Introductionmentioning

confidence: 99%

“…Minimally invasive surgery (MIS) has gained increasing widespread acceptance for pancreatectomies, with several meta-analyses reporting improved perioperative pain control, decrease postoperative morbidity rates and shorter postoperative length of stay associated with minimally-invasive pancreatectomies (MIP) 131415161718. These attendant advantages, alongside improved scar cosmesis and decreased long-term wound complications, would potentially prove especially invaluable in the typical SPPN patient which usually comprises young healthy females with a long-life expectancy 123789…”

Section: Introductionmentioning

confidence: 99%

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Outcome of minimally-invasive versus open pancreatectomies for solid pseudopapillary neoplasms of the pancreas: A 2:1 matched case-control study

Tan

Teo

et al. 2019

Ann Hepatobiliary Pancreat Surg

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Backgrounds/Aims Solid pseudopapillary neoplasm (SPPN) is typically seen in young healthy females who would likely benefit from minimally-invasive pancreatectomy (MIP). A few comparative studies have suggested that MIP is associated with favorable outcomes when compared to the open approach for SPPN. This study aims to mitigate potential selection bias by performing a matched case-control study comparing MIP vs open pancreatectomy (OP) for SPPN. Methods We performed a single-institution retrospective electronic chart review of all patients who underwent surgery for pathologically confirmed SPPN between 2000 and 2017. A 2:1 matched comparison using age, gender, tumor size and the type of pancreatectomy was performed between OP and MIP. Results A total of 40 patients with a median age of 40.3 years (range 16.5–64.4) and female sex predominance (n=34, 85.0%) underwent surgery during the study period. Nine patients underwent MIP. Matched comparison between 18 OP and 9 MIP demonstrated that MIP was associated with a longer median operating time (305 vs 180 min, p =0.046) and shorter median postoperative stay (6 vs 9 days, p =0.015). There were no significant differences in intraoperative blood loss, blood transfusion requirements, postoperative morbidity (including postoperative pancreatic fistula) and mortality, resection margins, lymph node yield and long-term survival. Conclusions MIP is a safe and viable option in the management of SPPN with the benefit of a shorter postoperative length of stay at the expense of a longer operation time. There was no significant difference in oncologic outcomes between both groups of patients.

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“…К сожалению, доказательных данных об этиологии, гистогенезе и факторам риска развития СППО ПЖЖ нет. Существуют предположения, что она развивается из дериватов потоковых [10,11], ацинарных [2,11] или колониеобразующих зародышевых клеток и из производных нервной пластинки. Кроме того, в литературе имеются описания экстраорганного развития СППО ПЖЖ из эктопированной ткани железы -в сальнике, брыжейке толстой кишки, печени [11].…”

Section: Introductionunclassified

Complications of solid pseudopapillary pancreatic tumors

Турсунов

Myrzakhmet

Yakovidi-Koneva

et al. 2019

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A solid pseudopapillary tumor of the pancreas is a very rare tumor of unclear histogenesis. Its frequency is 1–2% of the total number of exocrine tumors and about 5% of cystic tumors of the pancreas. Only 130 mainly publications related to separate clinical observations of this pathology are available in medical literature. We found no works describing the complicated course of a solid pseudopapillary tumor of the pancreas in children. The article describes a clinical case with a probable complicated, life threatening course of a solid pseudopapillary pancreatic tumor in children due to peptic erosion of tissues and vessels with capsular rapture.

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Solid Pseudopapillary Tumor of the Pancreas: A Single-center Experience and Review of the Literature

Cited by 27 publications

References 36 publications

Liver Transplantation for a Metastatic Pancreatic Solid-Pseudopapillary Tumor (Frantz Tumor): A Case Report

Liver Transplantation for a Metastatic Pancreatic Solid-Pseudopapillary Tumor (Frantz Tumor): A Case Report

Outcome of minimally-invasive versus open pancreatectomies for solid pseudopapillary neoplasms of the pancreas: A 2:1 matched case-control study

Complications of solid pseudopapillary pancreatic tumors

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