Solid Pseudopapillary Neoplasm of the Pancreas

Jiménez-Fuertes, Montiel; Ramírez-García, José Ramón; Ruíz-Tóvar, Jaime; García, Gustavo Díaz; Durán-Poveda, Manuel

doi:10.1016/j.cireng.2015.04.013

Cited by 66 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Solid pseudopapillary epithelial tumors of the pancreas are rare and occur most often in young women, as our two cases demonstrate [ 4 ]. Most of these tumors arise in the tail of the pancreas but can arise in the head of the pancreas, as our first case demonstrates.…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

Shu,

Ngock,

Lisongwe

et al. 2024

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Solid pseudopapillary epithelial neoplasm (SPEN) of the pancreas is a rare tumor of low malignant potential that occurs most often in young females. Imaging and histopathology are necessary to confirm the diagnosis as most have no symptoms. Lack of access to these technologies in sub-Saharan Africa contributes to the difficulty in making an early and accurate diagnosis, and hence, impedes treatment. We present two cases of SPEN of the pancreas in young female patients at a rural, teaching hospital in Cameroon. The diagnosis was made only with histopathology. Computed tomography scan with intravenous contrast was essential to planning a safe surgical resection. Both patients had complete surgical resection with good results.

show abstract

Section: Discussionmentioning

confidence: 85%

“…Immunohistochemistry is necessary for a definitive diagnosis [ 8 ]. This is important as liver enzymes and tumor markers are usually normal [ 4 , 6 ]. The liver is the most common site of metastases which occurs in an infiltrative pattern in about 15% of cases [ 1 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

Shu,

Ngock,

Lisongwe

et al. 2024

Journal of Surgical Case Reports

View full text Add to dashboard Cite

show abstract

“…Interestingly, there is a female predilection of SPN. Multiple studies described the female predominance and female-to-male ratio of nearly 5:1 [1, 5, 9–13]. Chhabra et al attributed the underlying female predominance to a relationship with sex hormones (i.e., estrogen and progesterone); however, their role in neoplasm growth and histogenesis remains debated [14].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Solid Pseudopapillary Tumor Associated with Elevated DHEA and Testosterone

Estifan

Cavanagh

Kapoor

et al. 2019

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

Solid pseudopapillary neoplasms (SPN) of the pancreas are extremely rare epithelial tumors with low malignant potential. They account for only 1-2% of pancreatic lesions. These masses often go unnoticed and when they become symptomatic it is often due to mass effect on neighboring structures. We encountered an unusual presentation in a healthy 34-year-old female who was found to have elevated dehydroepiandrosterone (DHEA) and testosterone levels during the evaluation of irregular menses. Subsequent abdominal imaging revealed an enhancing 2.7 cm pancreatic tail mass that was concerning for a pancreatic neoplasm. The patient underwent endoscopic ultrasound which confirmed the presence of a hypoechoic, 2.3 x 1.7 cm mass in the pancreatic tail. An intact interface was seen between the mass and adjacent structures, suggesting the absence of local invasion. Fine needle biopsy was performed and cytology was consistent with SPN. The patient later underwent curative distal pancreatectomy, with subsequent normalization of her menses. SPN are generally inactive on laboratory screening modalities (i.e., AFP, CEA, CA 19-9, and CA 125) and our patient showed no evidence of pancreatic insufficiency, pancreatic parenchymal injury, abnormal liver function, or cholestasis. Similarly to our patient, most SPN are asymptomatic. One retrospective study (spanning 15 years) reported vague abdominal pain in ~70% of patients, on initial presentation. Symptoms of tumor mass effect were the second most common. To our knowledge, this is the first reported presentation of elevated DHEA and testosterone levels associated with a solid pseudopapillary tumor in the absence of an underlying adrenal lesion or dysfunction. Despite extensive workup, no alternate etiology or correlatable medical condition could be elucidated for our patient’s hormonal dysregulation. We, therefore, recommend further review and investigation into this potential correlative relationship in an effort to guide the future diagnosis and management of this unusual neoplasm.

show abstract

“…No adjuvant therapy is recommended [17]. Prognosis is favourable, even in the presence of distant metastasis, and survival rates of more than 10 years have been described [19]. There are almost 100 cases of SPN of the pancreas reported in children among about 700 cases described [20].…”

Section: Discussionmentioning

confidence: 99%

Frantz tumor – a rare cause of abdominal pain in children – case report

Piechota-Mikuła

Strzelczuk-Judka

Mańkowski³

et al. 2014

Ann. Acad. Med. Siles.

View full text Add to dashboard Cite

The Frantz tumor (solid pseudopapillary neoplasm-SPN) is a rare, usually benign tumor of unclear etiology having a predilection for young women. This usually asymptomatic tumor may, however, be a cause of abdominal pain or discomfort. In our case, the mentioned tumor was a cause of abdominal pain in a 14-year-old, a so far healthy patient. Abdominal imaging-USG and computed tomography scan (CT) were performed showing a large mass in the left epi-and mesogastrium with primary location probably in the pancreas. A laparoscopic biopsy was performed and confirmed the initial diagnosis. A tumor along with the pancreatic tail were removed by laparotomy without complications. The case we described shows that a solid pseudopapillary neoplasm can be a rare cause of abdominal pain in pediatric patients.

show abstract

Solid Pseudopapillary Neoplasm of the Pancreas

Cited by 66 publications

References 14 publications

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

The diagnosis and management of solid pseudopapillary epithelial neoplasm of the pancreas in a resource-limited setting: two cases from Cameroon

Pancreatic Solid Pseudopapillary Tumor Associated with Elevated DHEA and Testosterone

Frantz tumor – a rare cause of abdominal pain in children – case report

Contact Info

Product

Resources

About