Solid Pseudopapillary Neoplasm of Pancreas; A Case Series and Review Literature

Abstract

BACKGROUND Information regarding solid pseudopapillary neoplasm (SPN) of the pancreas is limited in Iran. We aimed to review the clinicocytopathological features and follow-up of patients with SPN of pancreas who were diagnosed in a single center in Iran. METHODS Seven patients with SPN of the pancreas were diagnosed during January 2010 to March 2015 at the Digestive Disease Research Institute of Tehran University of Medical Sciences. The patients were reviewed prospectively. RESULTS Six out of the 7 patients were female and the mean age of all the patients was 29.4 years ranging from 15 to 61 years. The most common clinical presentation was nonspecific abdominal pain (N=6). The tumors were located mostly in head and neck of the pancreas. SPN was diagnosed in all patients by fine needle aspiration through endosonography (EUS-FNA). All patients underwent surgery. Histological findings of surgical tissues were consistent with EUS-FNA. The postoperative follow-up period of about 14 months was uneventful. CONCLUSION SPN of the pancreas is a rare pancreatic tumor which affects primarily young women. EUS-guided FNA could play an important role in preoperative diagnosis of SPN of the pancreas.

Solid pseudopapillary neoplasm of the pancreas: a report of 10 cases and literature review

“…The most common presenting symptoms are abdominal pain, followed by vomiting and nausea resulting from tumour compression on the adjacent organs and a palpable mass. Although, almost 30% of patients are completely asymptomatic and the tumour is incidentally discovered during diagnostic imaging procedures …”

Clinical update on the management of pseudopapillary tumor of pancreas

“…Symptoms are nonspecific. SPNs can present with palpable abdominal mass, indigestion, abdominal discomfort, epigastric pain, nausea, vomiting, asthenia, itching, weight loss, back pain, early satiety, bloating, jaundice and pancreatitis[ 23 , 27 , 41 , 42 ]. SPN outside the pancreas can occur in the retro-peritoneum , liver, stomach, mesentery, duodenum, omentum, ovary or lung[ 43 , 44 ].…”

Contribution of 18F-FDG PET/CT in the Staging of Pancreatic Solid Pseudopapillary Neoplasms: A Case Report

“…Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare epithelial tumor (1,2). The first cases of SPN were described by Frantz in 1959.…”

“…The first cases of SPN were described by Frantz in 1959. Since then, these lesions have been identified with different names until 2010 when the World Health Organization (WHO) defined SPN as a "low malignant epithelial neoplasm" and eliminated the term tumor (1)(2)(3).…”

“…SPNs are very rare pancreatic tumors, accounting for approximately 0.2% -2.7% of all exocrine pancreatic tumors, although with recent improvements in imaging the incidence increased up to 5% -6% of all pancreatic tumors diagnosed, mainly affecting females (femalemale ratio of 8:1) and young patients (between 28.5 and 36.8 years) (1,2). SPNs have a good prognosis, even in the presence of distant metastases (1,2).…”