Clinical update on the management of pseudopapillary tumor of pancreas

Lanke, Gandhi; Ali, Faisal S.; Lee, Jeffrey H.

doi:10.4253/wjge.v10.i9.145

Cited by 62 publications

(78 citation statements)

References 85 publications

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“…In some cases, patients may present nonspecific symptoms, including abdominal discomfort, nausea, vomiting, asthenia, or pain. 7 In patients with large neoplasms, acute abdomen resulting from traumatic intratumoral hemorrhage has been described. 3 Tumor markers' serum levels are within normal range, so they are not useful in the diagnostic workup.…”

Section: Epidemiologymentioning

confidence: 99%

Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features

Rosa

Bongiovanni

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Solid pseudopapillary neoplasm of the pancreas is a low-grade malignant tumor generally associated with a good prognosis. Solid pseudopapillary neoplasms show peculiar morphologic features, but sometimes the differential diagnosis with other pancreatic neoplasms (ie, pancreatic neuroendocrine tumors) can be a challenging task, especially in cytologic or biopsy specimens. In these cases immunohistochemistry is a useful tool, but the diagnostic utility of several proposed immunohistochemical markers is questionable. In recent years, despite several attempts to characterize the pathogenetic, molecular, and prognostic features of solid pseudopapillary neoplasms, they still remain unclear. Objective.— To give the reader a comprehensive update on this entity. Data Sources.— The PubMed database (US National Library of Medicine) was searched using the following string: pseudopapillary tumor [AND/OR] neoplasm [AND/OR] pancreas. All articles written in English were included. In addition, because a heterogeneous terminology has been used in the past to define solid pseudopapillary neoplasms, the reference lists of each paper selected in the PubMed database were also reviewed. Conclusions.— This review gives a comprehensive update on the pathologic, clinical, and molecular features of solid pseudopapillary neoplasms, particularly addressing issues and challenges related to diagnosis. In addition, we have tried to correlate the molecular alterations with the morphologic and clinical features.

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Section: Epidemiologymentioning

confidence: 99%

Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features

Rosa

Bongiovanni

2020

Archives of Pathology &Amp; Laboratory Medicine

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“…US examinations of SPTs usually show a homogeneous, hypoechogenic mass with a hyerpechogenic rim. 14 Computed tomography features include an encapsulated mass with varying solid and cystic components secondary to hemorrhagic degeneration. 14 At the periphery of the mass, both solid areas and calcifications can be seen.…”

Section: Discussionmentioning

confidence: 99%

“…14 Computed tomography features include an encapsulated mass with varying solid and cystic components secondary to hemorrhagic degeneration. 14 At the periphery of the mass, both solid areas and calcifications can be seen. 15 Typical MRI findings are a large, well-defined, encapsulated lesion with heterogeneous high-or low-signal intensity on T1-weighted and heterogeneous high signal intensity on T2-weighted images.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Distal Pancreatectomy of a Solid Pseudopapillary Tumor (SPT) Achieves Long-Term Oncologic Safety and Multiorgan Preservation

Elhaddad

Gasparella

Castellani

et al. 2019

European J Pediatr Surg Rep

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The oncological safety of a laparoscopic approach for solid pseudopapillary tumors (SPTs) of the pancreas remains a matter of debate. We present the long-term follow-up of an adolescent girl with an SPT in the pancreatic tail. A multimodality workup including magnetic resonance imaging (MRI) revealed a complex, spherical mass of 4.4 cm × 3.6 cm × 4 cm most likely located in the pancreatic tail. All routine laboratory investigations and tumor markers were within normal limits (alpha fetoprotein [AFP], cancer antigen 125 [CA125], CA 19–9, carcinoembryonic antigen [CEA], adrenocorticotropic hormone [ACTH]). Diagnostic laparoscopy was performed to verify the origin of the tumor in the pancreatic tail. In a three-port technique the tumor was mobilized of the splenic vessels until a distal pancreatectomy could be completed. Histopathological examination confirmed the complete resection of a low-grade malignant SPT. The postoperative course was unremarkable. Regular pediatric oncological follow-up examinations for 3 years, including MRI every 6 months, ruled out recurrence and confirmed preservation of splenic and pancreatic functions. While data about the technical feasibility of a laparoscopic approach to pancreatic SPT are already available, this pediatric case report adds a long-term oncological and functional success to the available literature.

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“…These survival rates are definitely better and more encouraging than those of PDACs or other aggressive histotypes. Furthermore, the more aggressive cases are often tumors that harbor an undifferentiated component or have peculiar pathological features usually associated with an aggressive behavior such as diffuse growth pattern, high mitotic activity, nuclear atypia, and tumor necrosis[ 4 , 38 , 39 ].…”

Section: Pseudopapillarymentioning

confidence: 99%

One size does not fit all for pancreatic cancers: A review on rare histologies and therapeutic approaches

Niger

Prisciandaro

Antista

et al. 2020

WJGO

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Exocrine pancreatic neoplasms represent up to 95% of pancreatic cancers (PCs) and are widely recognized among the most lethal solid cancers, with a very poor 5-year survival rate of 5%-10%. The remaining < 5% of PCs are neuroendocrine tumors that are usually characterized by a better prognosis, with a median overall survival of 3.6 years. The most common type of PC is pancreatic ductal adenocarcinoma (PDAC), which accounts for roughly 85% of all exocrine PCs. However up to 10% of exocrine PCs have rare histotypes, which are still poorly understood. These subtypes can be distinguished from PDAC in terms of pathology, imaging, clinical presentation and prognosis. Additionally, due to their rarity, any knowledge regarding these specific histotypes is mostly based on case reports and a small series of retrospective analyses. Therefore, treatment strategies are generally deduced from those used for PDAC, even if these patients are often excluded or not clearly represented in clinical trials for PDAC. For these reasons, it is essential to collect as much information as possible on the management of PC, as assimilating it with PDAC may lead to the potential mistreatment of these patients. Here, we report the most significant literature regarding the epidemiology, typical presentation, possible treatment strategies, and prognosis of the most relevant histotypes among rare PCs.

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Clinical update on the management of pseudopapillary tumor of pancreas

Cited by 62 publications

References 85 publications

Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features

Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features

Laparoscopic Distal Pancreatectomy of a Solid Pseudopapillary Tumor (SPT) Achieves Long-Term Oncologic Safety and Multiorgan Preservation

One size does not fit all for pancreatic cancers: A review on rare histologies and therapeutic approaches

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