Solid-phase optimisation for simultaneous determination of thirteen pharmaceuticals in Ethiopian water samples with HPLC-DAD detection: an initial assessment

Tegegne, Bisratewongel; Chandravanshi, Bhagwan Singh; Zewge, Feleke; Chimuka, Luke

doi:10.1007/s10661-021-08999-y

Cited by 15 publications

(7 citation statements)

References 48 publications

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“…The ComplexGAPI pentagrams in Table 4 reveal a better green profile of the proposed method than the reported methods. 28,36 The proposed method showed fewer red sections and more green sections, especially the sample treatment hexagon, as a result of the first pillar of the EVG framework by optimizing the consumption of solvents, energy savings, and minimum costs. The detailed analytical greenness reports for the ComplexGAPI metrics are shown in Table 4SM †…”

Section: Resultsmentioning

confidence: 99%

“…37,57–59 As previously mentioned, only LC-MS was reported for the analysis of these drugs simultaneously; thus, the proposed method was compared to reported HPLC-UV methods for the simultaneous quantitation of two drugs, CIP and SMZ, 36 as well as CIP and ALB. 28…”

Section: Resultsmentioning

confidence: 99%

“…37,[57][58][59] As previously mentioned, only LC-MS was reported for the analysis of these drugs simultaneously; thus, the proposed method was compared to reported HPLC-UV methods for the simultaneous quantitation of two drugs, CIP and SMZ, 36 as well as CIP and ALB. 28 The AGREE pictogram of the proposed method was altered to a greener color with a higher score of (0.55) compared to other reported methods. It can be related to the greener principles no.…”

Section: Greenness (Evg 3rd Pillar)mentioning

confidence: 93%

“…23,25,26 Albendazole (ALB) is an antiparasitic drug used to control anthelminthic parasites in humans and animals, and it belongs to the largest sector of the animal pharmaceutical industry. 27 Regardless of the high discharge of metabolized or unmetabolized anthelmintics into the environment, only few studies have quantified thirteen pharmaceutical compounds of different therapeutic classes in water samples using solid-phase extraction and HPLC-DAD, 28 measuring ALB 29 at surface water in the African region. These findings prompted the importance of investigations in the presence of CIP, SMZ and ALB in the Egyptian aquatic system.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An integrated framework to develop an efficient valid green (EVG) HPLC method for the assessment of antimicrobial pollutants with potential threats to human health in aquatic systems

Saleh,

Lotfy,

Elbalkiny

2023

Environ. Sci.: Processes Impacts

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Greenness (Evg 3rd Pillar)mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An integrated framework to develop an efficient valid green (EVG) HPLC method for the assessment of antimicrobial pollutants with potential threats to human health in aquatic systems

Saleh,

Lotfy,

Elbalkiny

2023

Environ. Sci.: Processes Impacts

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show abstract

“…To select the best eluent for eluting the analytes from the sorbent, water-miscible organic solvents including ACN, MeOH, and mixtures of their different proportions (80:20, 70:30, 50:50 v/v) were tested. These solvents were selected based on the fact that they could be suitable to desorb the targeted antibiotic analytes from the sorbent using minimum volume [38]. Figure 3 shows the results of the effect of the elution solvents on the recovery of the targeted compounds.…”

Section: Effect Of Elution Solvent Typementioning

confidence: 99%

Trace level enrichment and clean-up of β-lactam antibiotic residues in edible chicken tissues and feathers by solid phase extraction for quantitative determination utilizing liquid chromatography

Lakew¹,

Megersa²,

Chandravanshi³

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. A simple analytical method for the extraction and determination of three β-lactam antibiotics in chicken tissues and feather samples was developed and validated using solid phase extraction (SPE) and liquid chromatography-ultraviolet, LC-UV, detection. The analytes were extracted with strong anion exchange (SAX) cartridges for the extract clean-up and enrichment before introduction into the LC system. The validation was carried out based on the recommendations from Commission Decision 2002/657/EC. Under optimised conditions, the proposed method offers correlation coefficients of r2 ≥ 0.9991 for all the studied analytes in both matrices. Percent recovery results were found to vary between 79.7-101.8% and 94.2-101.6% for chicken feathers and tissues, respectively, with the relative standard deviation, RSD < 8.4%. The limits of detection (LOD) were in the range of 0.1-0.13 µg kg-1 and 0.1-0.15 µg kg-1 while the limits of quantification (LOQ) were in the range of 0.3-0.38 µg kg-1 and 0.3-4.5 µg kg-1 in chicken feathers and tissues, respectively. The proposed method offers good sensitivity and selectivity and all the results demonstrating that the method would be widely used for determination of β-lactam antibiotics and other trace level antibiotics residues having similar physical and chemical properties in the matrices of varying origins. KEY WORDS: Chicken tissues, Chicken feathers, β-Lactams, Solid phase extraction, LC-UV Bull. Chem. Soc. Ethiop. 2022, 36(3), 503-519. DOI: https://dx.doi.org/10.4314/bcse.v36i3.2

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The potential of three different adsorbents in solid‐phase extraction of antihistaminic and antimigraine drugs from water samples using ultra‐high‐performance liquid chromatography‐ultraviolet analysis

Jebali,

Labidi,

Sghaier

et al. 2023

Separation Science Plus

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In this study, eight pharmaceuticals belonging to two classes, antihistaminic and antimigraine, were considered. Ultra‐performance liquid chromatography‐diode array detection was set up and gradient elution was used. The mobile phase was composed of acetonitrile and trifluoroacetic acid solution. Chromatographic separation was carried out with a run time of 9 min. The preconcentration of eight studied solutes was realized by micro solid‐phase extraction. Multiwalled carbon nanotubes, cetyltrimethylammonium bromide‐titanium dioxide nanotubes, and C‐18 bonded silica solid‐phase extraction (SPE) sorbents were evaluated and compared concerning recoveries. The results of the optimization of factors affecting the extraction efficiency including sample volume, the elution solvent type, and its volume are reported. For validation of the analytical procedure, specificity, linearity, precision, accuracy, limit of detection, and limit of quantification were evaluated. The developed method was successfully applied to the analysis of wastewater treatment samples. The extraction recoveries of pharmaceutical substances were above 81.23% for the three SPE sorbents. The extraction method was selective and the detection and quantification limits were between 0.004–0.02 and 0.01–0.06 μg/L, respectively. All the results indicated the potential application of the three studied SPE sorbents for the extraction of selected pharmaceuticals from wastewater.

show abstract

Solid-phase optimisation for simultaneous determination of thirteen pharmaceuticals in Ethiopian water samples with HPLC-DAD detection: an initial assessment

Cited by 15 publications

References 48 publications

An integrated framework to develop an efficient valid green (EVG) HPLC method for the assessment of antimicrobial pollutants with potential threats to human health in aquatic systems

An integrated framework to develop an efficient valid green (EVG) HPLC method for the assessment of antimicrobial pollutants with potential threats to human health in aquatic systems

Trace level enrichment and clean-up of β-lactam antibiotic residues in edible chicken tissues and feathers by solid phase extraction for quantitative determination utilizing liquid chromatography

The potential of three different adsorbents in solid‐phase extraction of antihistaminic and antimigraine drugs from water samples using ultra‐high‐performance liquid chromatography‐ultraviolet analysis

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