Solid Phase Microextraction Coupled to High-Performance Liquid Chromatography

Chen, Jian; Pawliszyn, Janusz

doi:10.1021/ac00111a006

Cited by 323 publications

(151 citation statements)

References 9 publications

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“…2 Besides its application as an analytical method for the quantitative determination of organic pollutants and drugs in aqueous samples or in the headspace of aqueous samples, [3][4][5] SPME is increasingly being used to perform biomimetic extractions and to assess the bioavailability of organic pollutants in the presence of organic matrices. [6][7][8][9][10][11] Both strategies rely upon the premise that only the free aqueous concentration of a pollutant is available for biouptake and for partitioning into the polymer coating of the SPME fiber.…”

Section: Introductionmentioning

confidence: 99%

Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction

Escher

Berg

Mühlemann

et al. 2001

Analyst

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The extraction of two methylated anilines and three chlorinated phenols by solid-phase microextraction (SPME) fibers coated with polyacrylate was investigated as a function of pH. Only the neutral species of the acids and bases partitioned into the polymer. Extraction kinetics were accelerated for the hydrophobic phenols at pH values around their acidity constant. This is presumably due to a reconstitution of the neutral species in the unstirred aqueous layer adjacent to the polymer surface by the charged species through the fast acid-base equilibrium. Although the charged species is not taken up into the polymer, liposome/water distribution ratios could be measured up to a pH value, where 99% of the compounds were present as charged species. The partition coefficients of the neutral and charged species were extrapolated from the pH profiles of the liposome/water distribution ratios. The resulting values were slightly lower than those measured with equilibrium dialysis. The discrepancies are discussed with respect to differences in the experimental conditions and the possibility of matrix effects during SPME measurements.

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Section: Introductionmentioning

confidence: 99%

Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction

Escher

Berg

Mühlemann

et al. 2001

Analyst

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“…For example, Suchara et al (2008) developed an SPME method for simultaneous extraction of pharmaceutical compounds with acidic and basic characteristics (ibuprofen, fenoprofen, diclofenac, diazepam and loratadine), followed by GC/MS with LODs ranging from 0.02 to 0.43 μg l −1 . The coupling of SPME and liquid chromatography (LC) is more difficult because thermal desorption cannot completely desorb many non-volatile compounds typically detected by LC from the fibre (Chen & Pawliszyn 1995;Pichon 2000). As such, solvent desorption is necessary, but the challenge is to desorb analytes completely with a minimum amount of solvent to avoid significant impacts on chromatographic performance (Chen & Pawliszyn 1995).…”

Section: (I) Pre-treatmentmentioning

confidence: 99%

Practical overview of analytical methods for endocrine-disrupting compounds, pharmaceuticals and personal care products in water and wastewater

Comerton

Bagley

2009

Phil. Trans. R. Soc. A.

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The detection of organic micropollutants, such as endocrine-disrupting compounds, pharmaceuticals and personal care products, in wastewater and the aquatic environment has brought increasing concern over their potential adverse ecological and human impacts. These compounds are generally present at trace levels (ng l −1 ) and in complex water matrices, such as wastewaters and surface waters, making their analysis difficult. Currently, no standardized analytical methods are available for the analysis of organic micropollutants in environmental waters. Owing to the diversity of physico-chemical properties exhibited by the various classes of organic micropollutants, the majority of established analytical methods described in the literature focus on a specific class of compounds, with few methods applicable to multi-class compound analysis. As such, analytical challenges and limitations contribute to the lack of understanding of the effectiveness of drinking water and wastewater treatment processes to remove organic micropollutants. This paper provides a practical overview of current analytical methods that have been developed for the analysis of multiple classes of organic micropollutants from various water matrices and describes the challenges and limitations associated with the development of these methods.

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“…The two methods have different desorption steps. In most applications, SPME is hyphenated to GC, but recent studies have reported the hyphenation of SPME to HPLC for the speciation of various analytes [34].…”

Section: Desorptionmentioning

confidence: 99%

Applications of solid phase microextraction for the determination of metallic and organometallic species

Kaur

Malik²,

Verma

2006

J. Sep. Sci.

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Applications of solid phase microextraction for the determination of metallic and organometallic speciesThis paper reviews recent developments of solid phase microextraction (SPME) and its application to the analysis of organometallic species of lead, arsenic, mercury, tin, and selenium by hyphenation with HPLC-GC-atomic spectrometry. In the first part, a background of the technique is given in terms of derivatization, fibers used, extraction and desorption conditions. The second part summarizes typical SPME applications to the determination of organometallic species and the main experimental conditions with the aid of specific examples. Most of the applications comprise alkylation with NaBEt 4 and headspace extraction followed by gas chromatographic separation with a suitable detector.

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Solid Phase Microextraction Coupled to High-Performance Liquid Chromatography

Cited by 323 publications

References 9 publications

Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction

Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction

Practical overview of analytical methods for endocrine-disrupting compounds, pharmaceuticals and personal care products in water and wastewater

Applications of solid phase microextraction for the determination of metallic and organometallic species

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