Solid-phase microextraction: An appealing alternative for the determination of endogenous substances - A review

Huang, Siming; Chen, Guosheng; Ye, Niru; Kou, Xiaoxue; Zhu, Fang; Shen, Jun; Ouyang, Gangfeng

doi:10.1016/j.aca.2019.05.054

Cited by 98 publications

(36 citation statements)

References 200 publications

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“…SPME has been used routinely along with HPLC and GC for analyzing a wide variety of compounds (Risticevic, Niri, Vuckovic, & Pawliszyn, ). Over the past decades, several excellent reviews have successively been published, which elaborated the benefits, development, and future evolution of SPME in bioanalysis (Hamidi, Alipour‐Ghorbani, & Hamidi, ; Huang et al, ; Kataoka, ; Miekisch, Trefz, Bergmann, & Schubert, ). Each of these reviews covers a mass of SPME application in bioanalysis, such as pharmacotherapeutic and forensic analyses as well as the determination of endogenous substances, thus providing great reference values for readers.…”

Section: Sample Clean‐up and Recoverymentioning

confidence: 99%

“…A concentration equilibrium of the analytes between the sample matrix and the extraction phase is achieved during the SPME process, wherein the concentration of analyte extracted onto the coating corresponds to that of analyte existing in the sample matrix (Ahmad, 2013). SPME has been used routinely along with HPLC and GC for analyzing a wide variety of compounds (Risticevic, Niri, Vuckovic, & Pawliszyn, 2009 Human plasma and blood Kaewkhao et al (2019) evolution of SPME in bioanalysis (Hamidi, Alipour-Ghorbani, & Hamidi, 2018;Huang et al, 2019;Kataoka, 2015;Miekisch, Trefz, Bergmann, & Schubert, 2014). Each of these reviews covers a mass of SPME application in bioanalysis, such as pharmacotherapeutic and forensic analyses as well as the determination of endogenous substances, thus providing great reference values for readers.…”

Section: Spme and Enhanced Matrix Removal-lipidmentioning

confidence: 99%

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Technologies to improve the sensitivity of existing chromatographic methods used for bioanalytical studies

Chen

Gao

Zhong

2020

Biomedical Chromatography

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Chromatographic method has long been recognized as the most widely used separation method in bioanalytical research. However, the relatively low sensitivity of existing chromatographic methods remains a significant challenge, as the requirements for experimental procedures become more demanding. This review discusses the main causes for the low sensitivity of chromatographic methods and aims to introduce different technologies for enhancing their sensitivity in the following aspects: (i) different pretreatment methods for improving clean‐up efficiency and recovery; (ii) derivatization step for altering the chromatographic behavior of analytes and enhancing MS ionization efficiency; (iii) optimal LC–MS conditions and appropriate separation mechanism; and (iv) applications of other chromatographic methods, including miniaturized LC, 2D‐LC, 2D‐GC, and supercritical fluid chromatography. Altogether, this review is devoted to summarizing the recent technologies reported in the literature and providing new strategies for the detection of bioanalytes.

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Section: Sample Clean‐up and Recoverymentioning

confidence: 99%

Section: Spme and Enhanced Matrix Removal-lipidmentioning

confidence: 99%

Technologies to improve the sensitivity of existing chromatographic methods used for bioanalytical studies

Chen

Gao

Zhong

2020

Biomedical Chromatography

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“…Several review articles have been published in recent years on SPME, highlighting various application areas, developments, and materials/coatings [7,11,[16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Recently, a review article has been published as an overview of the most cited review articles on SPME covering theory, applications, automation, and future trends [30].…”

Section: Introductionmentioning

confidence: 99%

Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview

2020

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In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided.

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“…Analogously, detection of pollutants deriving from both anthropogenic and natural sources in living plants and animals can be useful to achieve information about the environmental conditions to which the organisms are exposed [11]. SPME coatings play a crucial role for in vivo applications: both commercial coatings, such as polydimethylsiloxane (PDMS), polyacrylate (PA) and divinylbenzene (DVB), and lab-made fibers based on the use of biocompatible coatings like C 18 , polydopamine (PDA), molecularly imprinted polymers (MIPs), mixed C 18 and cation exchange particles, polyacrylonitrile (PAN), hydrophilic lipophilic balanced particles (HLB) [1,[12][13][14][15][16][17][18][19][20] have been proposed with the final aim of improving both method sensitivity and selectivity. Novel geometry of SPME, like the thin-film microextraction blades (TF-SPME) [18] or biocompatible surface coated probes (BSCP) [21,22] have been also developed to provide higher sensitivity and reduced analysis time due both to the high surface area-to-volume ratio and to the possibility of a direct mass spectrometry (MS) coupling.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in In Vivo SPME Sampling

et al. 2020

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In vivo solid-phase microextraction (SPME) has been recently proposed for the extraction, clean-up and preconcentration of analytes of biological and clinical concern. Bioanalysis can be performed by sampling exo- or endogenous compounds directly in living organisms with minimum invasiveness. In this context, innovative and miniaturized devices characterized by both commercial and lab-made coatings for in vivo SPME tissue sampling have been proposed, thus assessing the feasibility of this technique for biomarker discovery, metabolomics studies or for evaluating the environmental conditions to which organisms can be exposed. Finally, the possibility of directly interfacing SPME to mass spectrometers represents a valuable tool for the rapid quali- and quantitative analysis of complex matrices. This review article provides a survey of in vivo SPME applications focusing on the extraction of tissues, cells and simple organisms. This survey will attempt to cover the state-of- the-art from 2014 up to 2019.

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Solid-phase microextraction: An appealing alternative for the determination of endogenous substances - A review

Cited by 98 publications

References 200 publications

Technologies to improve the sensitivity of existing chromatographic methods used for bioanalytical studies

Technologies to improve the sensitivity of existing chromatographic methods used for bioanalytical studies

Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview

Recent Advances in In Vivo SPME Sampling

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