Solid-phase extraction–high-performance liquid chromatography–ion trap mass spectrometry for analysis of trace concentrations of macrolide antibiotics in natural and waste water matrices

Yang, Shinwoo; Carlson, Kenneth

doi:10.1016/j.chroma.2004.02.084

Cited by 172 publications

(92 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Above mentioned antibiotics have been found to be sorbed to the residual metals on SPE cartridges and glassware, resulting in irreversible binding to the cartridge and lowering recovery. To obtain sufficient recovery from the environmental matrices some chelator should be added [30,31]. Chelating agents such as EDTA, oxalic acid and citric acid are usually applied to decrease the tendency for antibiotics to bind to cations in the matrix, to improve peak shape and to prevent interferences during the extraction of antibiotics [22].…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

“…The mostly referred preconcentration factor of sample was 500 or 1000 (see Table 1). LC-MS/MS [30] According to the sample volume used, usually 500 or 1000 mL of surface or ground water. When the wastewater sample was analyzed, lower volumes can be used for preconcentration because antibiotics occur there at higher concentration levels.…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

“…Thus, ERY-H 2 O is very often quantified in many studies [59], assuming that ERY is totally converted into ERY-H 2 O in SPE procedures. Additionally, since the oral administration of ERY has to pass through strongly acidic conditions in the stomach, the degraded product ERY-H 2 O, does not exhibit the original antibiotic properties [30].…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

“…MLs do not have any suitable chromophore group and this causes that MLs show poor UV absorbance, indicating that specific, selective and sensitive UV detection of these compounds in environmental waters is difficult [30]. One study refers the monitoring ERY, roxithromycin (ROXI) and tylosin (TLS) by UV, but the tandem MS was used for the accurate quantitation [30]. FD of MLs is possible with their derivatization.…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

“…The precursor ion chosen for the quantitation was [M+H] + in almost all studies, except of ERY-H 2 O, for which [M+H-H 2 O] + was used as a precursor ion [5,9,17,30].…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

See 4 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

310

170

View full text Add to dashboard Cite

a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

show abstract

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

Section: Macrolide Antibioticsmentioning

confidence: 99%

Section: Macrolide Antibioticsmentioning

confidence: 99%

“…The precursor ion chosen for the quantitation was [M+H] + in almost all studies, except of ERY-H 2 O, for which [M+H-H 2 O] + was used as a precursor ion [5,9,17,30].…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

310

170

View full text Add to dashboard Cite

show abstract

Mass Spectrometry

English¹,

Haag²

2011

Pharmaceutical Sciences Encyclopedia

View full text Add to dashboard Cite

Mass spectrometry (MS) has experienced tremendous growth throughout numerous scientific disciplines in the last few decades. This chapter will provide a concise summary of informative topics related to the study of therapeutic agents by MS. Our objective is to highlight as many pertinent MS techniques as possible. However, it should be noted that this will not be an all‐inclusive list of approaches due to the large volume of literature. This chapter will be primarily divided into the areas of instrumentation, sample preparation, and applications in proteomics, metabolomics, and emerging fields in drug analysis.

show abstract