Solid Organ Transplantation in HIV+ Recipients: Italian Experience

Morabito, Vincenzo; Grossi, Paolo; Lombardini, Letizia; Ricci, A.; Trapani, Silvia; Peritore, D.; Gaeta, Anna Michela; Ballanti, D.; Sordo, E. Del; Rizzato, Lucia; Costa, Alessandro Nanni

doi:10.1016/j.transproceed.2015.12.049

Cited by 17 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 , 21 , 22 Successful outcomes in heart, pancreas and lung transplants have also been reported in HIV-positive patients, despite using organs from HIV-negative donors. 23 , 24 , 25 , 26 …”

Section: Evidence To Datementioning

confidence: 99%

Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients

Nel

Conradie

Botha

et al. 2020

Southern African Journal of HIV Medicine

View full text Add to dashboard Cite

show abstract

Section: Evidence To Datementioning

confidence: 99%

Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients

Nel

Conradie

Botha

et al. 2020

Southern African Journal of HIV Medicine

View full text Add to dashboard Cite

show abstract

“…The intention was to increase the number of organs available to HIV-positive recipients. With this change, numerous new considerations need to be taken into account [9, 14, 19].…”

Section: The History Of Solid Organ Transplantation In Hiv-infected Imentioning

confidence: 99%

“…A large, multicentre Italian study described long-term transplant outcomes of liver, kidney, heart, lung and combined kidney-pancreas transplants in HIV-infected recipients [14]. Twenty-nine transplant centres participated, and 257 qualifying solid organ transplants were performed during the study period.…”

Section: Transplantation Outcomes In Hiv-positive Recipientsmentioning

confidence: 99%

See 1 more Smart Citation

HIV and Solid Organ Transplantation: Where Are we Now

et al. 2019

View full text Add to dashboard Cite

Purpose of ReviewWe review the international evolution of HIV and solid organ transplantation over 30 years. We emphasise recent developments in solid organ transplantation from HIV-infected to HIV-uninfected individuals, and their implications.Recent FindingsIn 2017, Johannesburg, South Africa, a life-saving partial liver transplant from an HIV-infected mother to her HIV-uninfected child was performed. This procedure laid the foundation not only for consideration of HIV-infected individuals as living donors, but also for the possibility that HIV-uninfected individuals could receive organs from HIV-infected donors.SummaryRecent advances in this field are inclusion of HIV-infected individuals as living organ donors and the possibility of offering HIV-uninfected individuals organs from HIV-infected donors who are well-controlled on combination antiretroviral therapy (cART). The large number of HIV-infected individuals on cART is an unutilised source of otherwise eligible living organ donors. HIV-positive-to-HIV-negative organ transplantation has become a reality, providing possible new therapeutic options to address extreme organ shortages.

show abstract

“…Based on these studies, HIV status was no longer considered as an absolute contraindication for lung transplantation . However, published cases of lung transplantation in HIV‐infected patients remain scarce …”

Section: Introductionmentioning

confidence: 99%

Double lung transplantation in an HIV‐positive patient with Mycobacterium kansasii infection

Ambaraghassi

Ferraro

Poirier

et al. 2018

Transplant Infectious Dis

View full text Add to dashboard Cite

Good outcomes with kidney and liver transplantation in HIV-positive patients have led clinicians to recommend lung transplantation in HIV-positive patients based on extrapolated data. Pre-transplant mycobacterial infection is associated with an increased risk of developing new infection or aggravating existing infection, though it does not contraindicate transplantation in non-HIV-infected patients. However, no data exists regarding the outcome of HIV-positive patients with pre-transplant mycobacterial infection. We report a case of double lung transplantation in a 50-year-old HIV-positive patient with alpha-1 antitrypsin deficiency. Prior to transplantation, Mycobacterium kansasii was isolated in one sputum culture and the patient was considered merely colonized as no clinical evidence of pulmonary or disseminated disease was present. The patient successfully underwent a double lung transplantation. Nontuberculous mycobacterial infection was diagnosed histologically on examination of native lungs. Surveillance and watchful waiting were chosen over treatment of the infection. HIV remained under control post-transplantation with no AIDS-defining illnesses throughout the follow-up. A minimal acute rejection that responded to increased corticosteroids was reported. At 12 months post-transplant, a bronchiolitis obliterans syndrome was diagnosed after a drop in FEV1. No evidence of isolation nor recurrence of nontuberculous mycobacteria was reported post-transplantation. At 15 months post-transplant, the patient remained stable with an FEV1 of 30%. The presence of pre-transplant nontuberculous mycobacterial infection did not translate into recurrence of nontuberculous mycobacterial infection post-transplant. Whether it contributed to bronchiolitis obliterans syndrome remains unknown.

show abstract

Solid Organ Transplantation in HIV+ Recipients: Italian Experience

Cited by 17 publications

References 21 publications

Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients

Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients

HIV and Solid Organ Transplantation: Where Are we Now

Double lung transplantation in an HIV‐positive patient with Mycobacterium kansasii infection

Contact Info

Product

Resources

About