Solid-liquid equilibrium data of amoxicillin and hydroxyphenylglycine in aqueous media

Bezerra, I. M.; Chiavone‐Filho, Osvaldo; Mattedi, Silvana

doi:10.1590/s0104-66322013000100006

Cited by 18 publications

(10 citation statements)

References 18 publications

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“…Finally, AMX solubility variation was observed in vitro (constant pH) from 2.3 g to 1.7 g when temperature decreased from 25°C to 10°C. Given the fact that body temperature of patients undergoing general anesthesia decrease roughly from 0.5°C to 1.5°C, the impact of potential intraoperative hypothermia appears marginal (22,23). Overall, those known precipitating factors are not new and cannot explain the recent AICN increase.…”

Section: Discussionmentioning

confidence: 99%

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Vodovar

Thomas

Lepeule

et al. 2018

Antimicrob Agents Chemother

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An increase in amoxicillin-induced crystal nephropathy (AICN) incidence has been recently suggested. The aims of this study were to investigate the trend of AICN incidence through Paris' regional centers of pharmacovigilance (Paris RCPVs) and better describe this rare adverse drug reaction. Forty-five AICN cases were identified between 1985 and 2016. All cases, except one, were reported since 2010. Amoxicillin (AMX) was administered intravenously (65 [interquartile range {IQR}, 43 to 110] mg/kg of body weight/day) in all patients, either for treating infection ( = 15) or as surgical prophylaxis ( = 30). Delay between AMX administration and AICN onset was 1 (IQR, 1 to 3) day; 30, 4, and 11 patients developed KDIGO stage 1, 2, and 3 acute kidney injury, respectively. Delay between AICN onset and kidney function recovery was 4 (IQR, 2 to 6) days. Precipitating factors were identified in only one-third of cases. Twelve patients required intensive care unit admission, and 8 needed renal replacement therapy. Neither chronic kidney disease nor death was observed. We confirmed the recent and dramatic increase of AICN in the Paris RCPVs since 2010. The absence of precipitating factors in the majority of cases and the onset of AICN in apparent routine indications, such as surgical prophylaxis, are alarming and justify a high vigilance from all AMX prescribers.

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Section: Discussionmentioning

confidence: 99%

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Vodovar

Thomas

Lepeule

et al. 2018

Antimicrob Agents Chemother

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“…The further negative Δ f 3 and a decrease in the slope may indicate the reorganization of molecules to minimize the energy and to free up more sites, as already described previously. 51 , 52 From the Δ f 3 values, the adsorption behavior of GLO onto Chi-77KS displays initial rapid adsorption, with a subsequent decline over an extended period. A similar behavior in the case of Δ f 3 is noticed for Chi-77KS/AMOX, but the dissipation showed the opposite trend, where it increased as the adsorption progressed.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

Ajdnik

Zemljič

Plohl

et al. 2021

ACS Appl. Mater. Interfaces

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Medical implant-associated infections resulting from biofilm formation triggered by unspecific protein adsorption are the prevailing cause of implant failure. However, implant surfaces rendered with multifunctional bioactive nanocoatings offer a promising alternative to prevent the initial attachment of bacteria and effectively interrupt biofilm formation. The need to research and develop novel and stable bioactive nanocoatings for medical implants and a comprehensive understanding of their properties in contact with the complex biological environment are crucial. In this study, we developed an aqueous stable and crosslinker-free polyelectrolyte–surfactant complex (PESC) composed of a renewable cationic polysaccharide, chitosan, a lysine-based anionic surfactant (77KS), and an amphoteric antibiotic, amoxicillin, which is widely used to treat a number of infections caused by bacteria. We successfully introduced the PESC as bioactive functional nanolayers on the “model” and “real” polydimethylsiloxane (PDMS) surfaces under dynamic and ambient conditions. Besides their high stability and improved wettability, these uniformly deposited nanolayers (thickness: 44–61 nm) with mixed charges exhibited strong repulsion toward three model blood proteins (serum albumin, fibrinogen, and γ-globulin) and their competitive interactions in the mixture in real-time, as demonstrated using a quartz crystal microbalance with dissipation (QCM-D). The functional nanolayers with a maximum negative zeta potential (ζ: −19 to −30 mV at pH 7.4), water content (1628–1810 ng cm –2 ), and hydration (low viscosity and elastic shear modulus) correlated with the mass, conformation, and interaction nature of proteins. In vitro antimicrobial activity testing under dynamic conditions showed that the charged nanolayers actively inhibited the growth of both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria compared to unmodified PDMS. Given the ease of fabrication of multifunctional and charged biobased coatings with simultaneous protein-repellent and antimicrobial activities, the limitations of individual approaches could be overcome leading to a better and advanced design of various medical devices (e.g., catheters, prosthetics, and stents).

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“…At room temperature, amoxicillin has pK a1 = 2.74 and pK a2 = 6.98. At a high pH value, the hydrolysis of the amoxicillin is observed [26].…”

Section: Discussionmentioning

confidence: 99%

A Novel Optimized Formulation for Cooling Tower Effluent Disinfection: Tarasht Power Plant Case Study

Sohrabi

Iranshahi

et al. 2021

Preprint

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Since the operating conditions of the cooling tower units provide such a suitable environment for the growth of bacteria and algae, taking measures for the disinfection process is strongly recommended. The cooling tower unit is proceeded by RO and the disinfection strategy is sodium hypochlorite, combined with this new formulation. The sampling result revealed that bacteria counts from the effluent of the cooling tower are 2600 CFU/ml while the microbial load of the water in the pond is 220 CFU/ml. Herein, two type formulations are introduced for cooling tower output stream while the pond water comes along with a NaOCl injection. The dosage of A: Glucose Oxidase, B: ammonium persulfate, and C: Amoxicillin, and D: the order of use are chosen as the four independent variables whose effects and their binary interactions on microbial load and disinfection efficiency were investigated via Box–Behnken design (BBD) combined with response surface methodology (RSM). The ANOVA results show that the most significant variable is amoxicillin in the presence of bleach. Meanwhile, high values for R2 > 0.99 and the model F-value 45.64 in addition to diagnostic tests confirmed the reliability of the model. Several solutions have been introduced as optimum formulations. The pre-scale up and economic considerations have been included.

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Solid-liquid equilibrium data of amoxicillin and hydroxyphenylglycine in aqueous media

Cited by 18 publications

References 18 publications

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Dramatic Increase of Amoxicillin-Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers

Bioactive Functional Nanolayers of Chitosan–Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants

A Novel Optimized Formulation for Cooling Tower Effluent Disinfection: Tarasht Power Plant Case Study

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