Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil

Delivery of drugs applied topically to the skin

“…Vaccines, 5-fluorouracil, IL-2 and IFN-α [149][150][151] SECosomes or nanosomes Mixture of surfactant, ethanol and cholesterol siRNA [121] SLNs Produced with one single solid lipid and surfactants, with perfect crystalline lattice CoQ-10, glucocorticoids, minoxidil and oxybenzone [152][153][154][155] NLCs Produced with solid and liquid lipids and surfactants, with distorted crystalline lattice Targeted tumor delivery, phospholipase A2 inhibitors, benzocaine, lidocaine and psoriasis treatment [156][157][158][159] Polymeric nanoparticles Consist of micro-and nano-spheres or capsules developed to control the release of the entrapped drug Chlorhexidine, indomethacin, melatonin and poorly soluble drugs [160][161][162][163] ALA: Aminolevulinic acid; NLC: Nanostructured lipid carrier; SECosome: Surfactant-ethanol-cholesterol-osome; SLN: Solid lipid nanoparticle.…”

Nanotechnology-Based Cosmetics for Hair Care

“…One study found that encapsulating minoxidil into solid lipid nanoparticles showed similar skin penetration to commercial solutions without the corrosive potential (i.e., dryness, irritation, burning, etc.) [47]. Finasteride, a 5-α reductase inhibitor preventing the peripheral conversion of testosterone to dihydrotestosterone, has a variety of unwanted side effects following oral administration; encapsulation of finasteride into topical liquid crystalline nanoparticles has been proposed as a viable alternative to oral administration in order to maintain high skin retention in the scalp, enable a lower dosing frequency and minimize significant side effects including mood disturbances, gynecomastia and erectile dysfunction [48].…”

Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies

“…After 24 hours, only a very small quantity of minoxidil crossed the skin. A previous study 1 indicated the difficulty that exists in this drug penetrating through the skin. Therefore, the results obtained in this work were not different than what was expected, according to the literature.…”

“…This disease has different possible forms; androgenic alopecia (AGA) is a common form of hair loss in both men and women. 1 It affects up to half of the Caucasian male population by middle age, and almost all (95%) Caucasian men by old age (80 years). 2 This type of alopecia is progressive and related to a perturbation of the hair follicle cycle, which is caused by a shortening of the anagen stage, with the clinical consequence of increased hair loss accompanied by a transformation of terminal…”

“…Lipid nanoparticles (LNs), such as solid LNs and nanostructured lipid carriers (NLCs), are composed of physiological (biocompatible) and biodegradable lipids, 1 which possess low cytotoxicity and low systemic toxicity and thus high tolerability. [6][7][8] LNs exhibit many advantageous features for dermal application of cosmetic and pharmaceutical products, such as: controlled drug release and drug targeting; improved drug physical stability; feasibility to incorporate lipophilic and hydrophilic drugs; avoidance of organic solvents; and no problems with respect to large-scale production and sterilization.…”