Solid lipid nanoparticles of <i>Annona muricata</i> fruit extract: formulation, optimization and <i>in vitro</i> cytotoxicity studies

Sabapati, Mohanalakshmi; Palei, Narahari N.; K, Ashok Kumar C; Molakpogu, Ravindra Babu

doi:10.1080/03639045.2019.1569027

Cited by 32 publications

(11 citation statements)

References 38 publications

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“…)- -Olean-13(18)-ene -7,22-ergostadienone -Lupan-3-ol, acetate -Stigmasta-4,22-diene [ 136 ] Pteris quadriaurita Leaves Methanol -Gold nanoparticles -MCF-7 cell line -BT-47 cell line -0–125 µg/mL -0–500 µg/mL -9 µg/mL (24 h) -460 µg/mL (24 h) -↑ Cytotoxicity a -↑ Anti-proliferative activity a -↑ Cell cycle arrest-inducing activity a -↑ Pro-apoptotic activity a -N/A -Phytol -2-pentadecanone, 6,10,14-trimethyl- -1.4-eicosadiene -Hexadecanoic acid, methyl ester -1-hexadecen-3-ol, 3,5,11,15-tetramethyl- -N-hexadecanoic acid -Linoleic acid ethyl ester -9.12-octadecadienoyl chloride, (Z,Z)- -Octadecanoic acid, methyl ester -(R)-(-)-14-methyl-8-hexadecyn-1-ol -Octadecanoic acid -5,8,11,14,17-eicosapentaenoic acid -Palmitoyl chloride -4,8,12,16-tetramethylheptadecan-4-olide -1,3,5-trisilacyclohexane -Heptacosane -Eicosane, 9-octyl- -Indan, 1-methyl-3-nonyl- -Heptasiloxane, hexadecamethyl- -2H-1-Benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-(4,8,12-trimethyltridec -Octasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl- -Cholesta-4,6-dien-3-ol, (3.beta. )- -Stigmastan-3,5-diene -DL-.alpha.-tocopherol -Octasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl- -Olean-13(18)-ene [ 136 ] Annona muricata Fruits Ethanol -Solid lipid nanoparticles -MCF-7 cell line -6.25–100 µg/mL -12 µg/mL (24 h) -↑ Cytotoxicity a -↑ Pro-apoptotic activity a -N/A -Alkaloids -Cardiac glycosides -Flavonoids -Phenols -Reducing sugars -Steroids -Terpenoids [ 155 ] Peels Deionised distilled water -Silver nanoparticles -AMJ-13 cell line -25 µg/mL -17.34 µg/mL -17.34 µg/mL (N/A) ...…”

Section: The Anti-breast Cancer Mechanisms Of Medicinal Plant Extracts/essential Oils and Anti-breast Cancer Activities Of Their Nanoformmentioning

confidence: 99%

“…Sabapati et al 155 loaded A. muricata ethanolic fruit extract into SLNs and found that extract-loaded SLNs caused a greater dose-dependent reduction in MCF-7 cell viability than the free extract (IC 50 values of 12 µg/mL vs 30 µg/mL). Flow cytometric analysis of Annexin V-FITC-stained cells further showed that extract-loaded SLNs could induce a significantly higher percentage of apoptotic MCF-7 cell death than the free extract (86.0% vs 71.34%).…”

Section: The Anti-breast Cancer Mechanisms Of Medicinal Plant Extracts/essential Oils and Anti-breast Cancer Activities Of Their Nanoformmentioning

confidence: 99%

See 1 more Smart Citation

Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature

Yap¹,

Sekar²,

Fuloria³

et al. 2021

IJN

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Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a global health issue affecting millions of women annually. Poor prognosis in BC patients is often linked to drug resistance as well as the lack of effective therapeutic options for metastatic and triple-negative BC. In response to these unmet needs, extensive research efforts have been devoted to exploring the anti-BC potentials of natural products owing to their multi-target mechanisms of action and good safety profiles. Various medicinal plant extracts/essential oils and natural bioactive compounds have demonstrated anti-cancer activities in preclinical BC models. Despite the promising preclinical results, however, the clinical translation of natural products has often been hindered by their poor stability, aqueous solubility and bioavailability. There have been attempts to overcome these limitations, particularly via the use of nano-based drug delivery systems (NDDSs). This review highlights the tumour targeting mechanisms of NDDSs, the advantages and disadvantages of the major classes of NDDSs and their current clinical status in BC treatment. Besides, it also discusses the proposed anti-BC mechanisms and nanoformulations of nine medicinal plants’ extracts/essential oils and nine natural bioactive compounds; selected via the screening of various scientific databases, including PubMed, Scopus and Google Scholar, based on the following keywords: “Natural Product AND Nanoparticle AND Breast Cancer”. Overall, these nanoformulations exhibit improved anti-cancer efficacy against preclinical BC models, with some demonstrating biocompatibility with normal cell lines and mouse models. Further clinical studies are, however, warranted to ascertain their efficacy and biocompatibility in humans.

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Section: The Anti-breast Cancer Mechanisms Of Medicinal Plant Extracts/essential Oils and Anti-breast Cancer Activities Of Their Nanoformmentioning

confidence: 99%

Section: The Anti-breast Cancer Mechanisms Of Medicinal Plant Extracts/essential Oils and Anti-breast Cancer Activities Of Their Nanoformmentioning

confidence: 99%

Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature

Yap¹,

Sekar²,

Fuloria³

et al. 2021

IJN

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show abstract

“…In the new drug delivery system, the sample drugs used are microparticle or natural nanoparticle products, and the references used are free drugs that are not within the microparticle or nanoparticle matrix. The methods that can be used in this process are the sink method [21,38], dialysis bag method [30,42,43], and static dialysis method [47].…”

Section: In Vitro Release Testmentioning

confidence: 99%

A Review: Anti-Cancer Natural Product Drug Delivery System Dosage Form and Evaluation

2021

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A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.

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“…They are presented with their coded levels in Table 1. More precisely, the main effects of each factor as well as their interaction effects on the nanoparticle size distribution were investigated by carrying out eight runs that were determined by a 2 3 full factorial design (Table 2) [45]. Two experimental responses were measured by dynamic light scattering (DLS) analyses: the polydispersity index (PDI) (Y 1 ) and the mean particle size (d) (Y 2 ).…”

Section: Design Of Experimentsmentioning

confidence: 99%

Non-isocyanate polyurethane nanoprecipitation: Toward an optimized preparation of poly(hydroxy)urethane nanoparticles

Querette

Bordes

Sintès‐Zydowicz

2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies

Cited by 32 publications

References 38 publications

Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature

Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature

A Review: Anti-Cancer Natural Product Drug Delivery System Dosage Form and Evaluation

Non-isocyanate polyurethane nanoprecipitation: Toward an optimized preparation of poly(hydroxy)urethane nanoparticles

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