Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Celecoxib for Topical Application – Preparation, Characterization and Drug Penetration Through Rat Skin

Üner, Melike; Yener, Gülgün; Ergüven, Mıne; Karaman, Ecem Fatma; Utku, Elif Gozde

doi:10.2174/1573413710666140218231307

Cited by 13 publications

(11 citation statements)

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“…As per information gathered by DSC experiments on formulations, melting points of nanoparticles were distinguished to diminish to lower temperatures in conjunction with broader peaks contrasted with bulk lipid by giving variable enthalpy values additionally showing several thermal transitions. 20,21 The melting points of the lipid only shown at 61.58°C and 57.84°C (enthalpy of -628.05 and -363.85 mJ) through DSC analysis of the SLN and NLC formulation respectively this implies that the drug is obviously dissolved in the lipid and dispersed in the lipid phase molecularly (Figure 3). It was also observed a depression in melting point of NLC due to presence of liquid lipid (Eucalyptus oil).…”

Section: Discussionmentioning

confidence: 99%

Nanostructured Lipid Carrier (NLC) and Solid Lipid Nanoparticles (SLN) Based Hydrogel for Delivery of Etodolac: A Comparative Investigation on Dermal Pharmacokinetic on Rat Skin

Patel

Kesharwani

Kumar

2021

JPHI

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Objectives:The present work focus on to create Solid lipid nanoparticles (SLN) and nanostructured lipid Carrier (NLC) as transporters for effective delivery of Etodolac (ETD). Methods: Etodolac stacked SLN and NLC were set up by melting emulsification and hardening at low temperature method and they were portrayed for molecule size, zeta potential, encapsulation efficacy and in vitro discharge rate. Ex vivo dermatokinetic by tape stripping technique was explored in rat skin utilizing altered Franz diffusion cells. The praticle size and the surface electrical charge (ZP) have been assessed following after manufacturing of dispersion. Results: The particles stayed in their colloidal range after production by melt emulsification method. For all nano dispersion the encapsulation efficacy was higher than 75%. Differential Scanning calorimetry (DSC) were performed to portray the physicochemical properties of the SLN and NLC. Approximately Same amount of Etodolac release was facilitated through skin of rats from SLN-SA and NLC-SA. Conclusion: Research work could be concluded as successful development of Etodolac loaded SLN and NLC to increase the encapsulation efficiency of colloidal lipid carriers with benefit of higher performance in terms of long term stability and impart a sustaining Etodolac topical effect as well as faster relief from pain associated with arthritis.

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Section: Discussionmentioning

confidence: 99%

Nanostructured Lipid Carrier (NLC) and Solid Lipid Nanoparticles (SLN) Based Hydrogel for Delivery of Etodolac: A Comparative Investigation on Dermal Pharmacokinetic on Rat Skin

Patel

Kesharwani

Kumar

2021

JPHI

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“…Franz-type diffusion cells were used to determine 18-β GA permeation through the skin [22]. For ex vivo skin penetration and permeation assessments, abdomens of animals were precisely shaved 2 days prior to the in vivo study.…”

Section: Ex Vivo Skin Penetration and Permeation Studiesmentioning

confidence: 99%

Influence of Vehicles and Penetration Enhancers on Anti-Inflammatory Effect of 18-Β Glycyrrhetinic Acid: Kinetic Modelling of Drug Release, in Vivo and Ex Vivo Experiments

Karaman¹,

Çelik²,

Özdemir³

et al. 2020

FARMACIA

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Topical formulations of 18-β glycyrrhetinic acid (18-β GA) were designed for use in relieving inflammatory and painful conditions of the skin. Formulations were containing penetration enhancers that differ in penetration enhancing mechanisms. Anti-inflammatory effects of formulations and effects of penetration enhancers on penetration and permeation of the drug through rat skin were investigated. The total amount of 18-β GA permeated from the base oil/water emulsion (53.19 ± 22.25 mcg/cm 2 ) was approximately twice higher than the base oleaginous cream (29.17 ± 3.85 mcg/cm 2 ) while there was no 18-β GA permeation from the base hydrogel formulation to the skin (p < 0.05). Incorporation of propylene glycol was generally found to increase 18-β GA permeation to the skin. The highest oedema inhibiting activity was achieved in the oil/water emulsion containing propylene glycol followed by the base oil/water emulsion without a penetration enhancer (p < 0.05). This result was consistent with the ex vivo study. Limonene and oleic acid were found to be insufficient in 18-β GA permeation to the skin. RezumatAu fost elaborate formulări topice ale acidului gliciretinic 18-β (GA 18-β), cu promotori de penetrare, pentru utilizarea acestora în ameliorarea bolilor inflamatorii ale pielii. Au fost cercetate efectele antiinflamatoare ale formulărilor și efectele promotorilor de penetrare asupra penetrării și permeării medicamentului prin pielea șobolanului. Cantitatea totală de 18-β GA pătrunsă în piele din emulsia de bază U/A (53,19 ± 22,25 mcg/cm 2 ) a fost aproximativ de două ori mai mare decât din crema oleaginoasă (29,17 ± 3,85 mcg/cm 2 ). Nu a existat o permeare de 18-β GA din formularea hidrogelului de bază (p < 0,05). Încorporarea propilenglicolului a crescut permeabilitatea GA-18-β în piele. Cea mai mare activitate de inhibare a edemelor a fost obținută cu emulsia U/A conținând propilenglicol, urmată de emulsia U/A de bază fără promotor de penetrare (p < 0,05). Acest rezultat a fost în concordanță cu studiul ex vivo. Limonenul și acidul oleic s-au dovedit a fi insuficiente în creșterea permeabilității GA-18-β prin piele.

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“…Figura 20-Gráfico de Pareto dos efeitos padronizados para os fatores tipo de óleo (A), tempo de sonicação (B) e interações entre tipo de lipídeo e tempo de sonicação (AB) para a resposta índice de polidispersão (PdI). CLN (ZAMIRI et al, 2016;DOUNG et al,2009;BAHARI et al, 2016) e o Óleo de coco foi descrito como um dos mais comumente utilizados para o preparação destes sistemas (SUTARIYA et al, 2015;ÜNER et al, 2014).…”

Section: Planejamento Fatorial 2unclassified

“…É relevante mencionar que o óleo é adicionado ao carreador com intuito de deixá-lo com uma estrutura cristalina mais desorganizada. Estudos demostraram que a introdução e o aumento da quantidade óleo diminuem a cristalinidade ou desorganizam a estrutura cristalina de CLN (KAWADKAR et al, 2013;ÜNER et al, 2014). Ademais, a desorganização na estrutura pode permitir ao carreador abrigar mais ativo e impedir a expulsão do mesmo durante o período de estocagem (MARCATO, 2009;TAMJIDI et al, 2013), visto que o fármaco se acomoda nas imperfeições da estrutura cristalina, entre as cadeias de lipídeo MÜLLER, 2003 andMÜLLER et al, 2007).…”

Section: Soma Dos Quadradosunclassified

“…Além disso, o comportamento de cristalização das partículas pode ser determinante na expulsão ou não do ativo durante o tempo de estocagem (TAMJIDI et al, 2013). No período de estocagem o lipídeo que compõe as nanopartículas pode sofrer uma transformação em sua e trutura cri ta ina, caracteriza a e a tran i a f r a cri ta ina α ( en r aniza a) ara a f r a cri ta ina β ( ai r aniza a) (ÜNER et al, 2014). Esta u an a c rre, i a f r a β é ener etica ente ai e t el.…”

Section: Calorimetria Exploratória Diferencial (Dsc)unclassified

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Preparação, caracterização e avaliação do potencial citotóxico in vitro de carreadores lipídicos nanoestruturados funcionalizados com folato encapsulando quercetina em células de câncer de bexiga

Silva¹

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Barcellos pela amizade sincera, vivências, apoio nas horas decisivas e por tornarem esta etapa ainda mais especial para mim. Ao técnico Luis Henrique Cenzi pela ajuda e apoio dentro do laboratório e amizade. À família Nanobiolab. À Professora Doutora Kamilla Swiech pela acolhida em seu laboratório, confiança e por toda a colaboração. Ao técnico Fernando Fernandes pela ajuda e apoio dentro do laboratório de Cultivo de Células e Bioprocessos. À técnica Mariana por toda gentileza e apoio e ao Laboratório de Controle de Qualidade por disponibilizar o HPLC. Ao Professor Doutor Flávio Emery, ao técnico Murilo de Paula e ao Doutor Lucas Resende pela colaboração e contribuição para produção do Pluronic funcionalizado.

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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Celecoxib for Topical Application – Preparation, Characterization and Drug Penetration Through Rat Skin

Cited by 13 publications

References 0 publications

Nanostructured Lipid Carrier (NLC) and Solid Lipid Nanoparticles (SLN) Based Hydrogel for Delivery of Etodolac: A Comparative Investigation on Dermal Pharmacokinetic on Rat Skin

Nanostructured Lipid Carrier (NLC) and Solid Lipid Nanoparticles (SLN) Based Hydrogel for Delivery of Etodolac: A Comparative Investigation on Dermal Pharmacokinetic on Rat Skin

Influence of Vehicles and Penetration Enhancers on Anti-Inflammatory Effect of 18-Β Glycyrrhetinic Acid: Kinetic Modelling of Drug Release, in Vivo and Ex Vivo Experiments

Preparação, caracterização e avaliação do potencial citotóxico in vitro de carreadores lipídicos nanoestruturados funcionalizados com folato encapsulando quercetina em células de câncer de bexiga

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