Solid Lipid Nanoparticles- An Innovative Approach for Improving the Solubility and Bioavailability

Abstract

The purpose of this study is to give a general review on solid lipid nanoparticles (SLNs) as a novel drug carrier for improving the solubility and bioavailability of drugs. Approach: Among the various colloidal drug carriers, SLNs have been emerged as next generation drug delivery system for incorporating lipophilic drugs. They are relatively nontoxic and nonirritant. The review insight on the various methods of preparation, characterization and also the application of SLNs for improving the solubility and bioavailability is explained here. Findings: SLNs is used as a novel carrier for improving the solubility of poorly soluble drugs which may results in enhanced bioavailability and stability of drug can also be improved by incorporating drug in the form of solid lipid nanoparticles. Conclusion: This review presents an overview of SLNs which includes SLN and its properties, excipients, techniques used in preparation of SLNs, characterization, and their applications.

A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery

“…6,7,82 DSC works on the fact that different lipids modifications have different melting points and melting energy. 5 Infrared Radiation spectroscopy and Raman spectroscopy both techniques are used to find out the structural properties of lipids.…”

“…Insoluble drug delivery strategies: review of recent advances and business prospects [3][4] Solid lipid nanoparticles (SLNs) as a colloidal carrier have proved their potential by surpassing the limitations of other carriers from the early 1990s. 5 Several potent formulations do not show success in therapy, leading to an increase in the rejection rate of API from the FDA. Factors that contribute to treatment failure include low absorption and fast metabolism, indiscriminate drug distribution leading to insufficient drug concentration (e.g.…”