Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

Mendoza‐Muñoz, Néstor; Urbán-Morlán, Zaida; Leyva-Gómez, Gerardo; Zambrano-Zaragoza, María L.; Piñón-Segundo, Elizabeth; Quintanar‐Guerrero, David

doi:10.18433/jpps31788

Cited by 37 publications

(22 citation statements)

References 98 publications

(117 reference statements)

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“…SLNs have been widely applied for delivery of drugs for neurological diseases and cancer, and for preventing antibiotic resistance, because this carrier can contain many antimicrobial drugs, increase drug absorption, and reduce bacterial efflux. SLNs are a good alternative in terms of functionality and biocompatibility, because they can directly reach the site of infection, increase drug bioavailability, and reduce toxicity or side effects [ 122 ].…”

Section: Applications Of Slns In Various Fieldsmentioning

confidence: 99%

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

2023

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Various active compounds are easily damaged, so they need protection and must be easily absorbed and targeted. This problem can be overcome by encapsulating in the form of solid lipid nanoparticles (SLNs). Initially, SLNs were widely used to encapsulate hydrophobic (non-polar) active compounds because of their matched affinity and interactions. Currently, SLNs are being widely used for the encapsulation of hydrophilic (polar) and semipolar active compounds, but there are challenges, including increasing their entrapment efficiency. This review provides information on current research on SLNs for encapsulation and delivery systems for active and antioxidant compounds, which includes various synthesis methods and applications of SLNs in various fields of utilization. SLNs can be developed starting from the selection of solid lipid matrices, emulsifiers/surfactants, types of active compounds or antioxidants, synthesis methods, and their applications or utilization. The type of lipid used determines crystal formation, control of active compound release, and encapsulation efficiency. Various methods can be used in the SLN fabrication of active compounds and hydrophilic/hydrophobic antioxidants, which have advantages and disadvantages. Fabrication design, which includes the selection of lipid matrices, surfactants, and fabrication methods, determines the characteristics of SLNs. High-shear homogenization combined with ultrasonication is the recommended method and has been widely used because of the ease of preparation and good results. Appropriate fabrication design can produce SLNs with stable active compounds and antioxidants that become suitable encapsulation systems for various applications or uses.

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Section: Applications Of Slns In Various Fieldsmentioning

confidence: 99%

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

2023

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“… SLNs are being broadly studied for delivering anti-cancer drugs by incorporating them into an SLN formulation to improve oral bioavailability of drugs, protecting them from labile environment & also helpful in reducing adverse effects by minimizing the dosage by effective targeting to site of action 27 . There is various drugs approved by FDA  Additional medical study on lipid nanoparticles for releasing mRNA to solid cancer cells or lymphoma is presently underway (NCT03739931).…”

Section: Slns and Anticancer Drug Deliverymentioning

confidence: 99%

Untitled

2023

IJPSR

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Nanoparticles with lipids as a constituent are called "solid lipid nanoparticles" (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aids in the solubilization of lipophilic compounds. The evolution of multidrug resistance therapy against various chemotherapeutic agents, tissue toxicity, and a high prevalence of drug-resistant tumors are the most common impediments in the clinical management of cancer. For more than a decade, SLNs have been widely used as drug delivery systems in the treatment of various cancers due to their low toxicity, high drug bioavailability, and usefulness with hydrophilic and lipophilic drugs. In this review, we discussed the incorporation and controlled delivery of different cytotoxic anti-cancer drugs to target sites using SLNs to treat various malignancies.

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“…SLNPs [ 56 , 57 ], similarly to polymer-based nanoscale delivery systems, can improve the absorption and bioavailability of drugs with a low solubility and can protect molecules, which are labile in an acidic environment and can enable the targeting of drugs to their side of action and can reduce adverse side effects [ 169 ]; the emergence of antibiotic resistance can be reduced by the incorporation of antibiotics into SLNPs [ 170 ]. Ascorbyl tocopherol succinate, which is used as an adjuvant in SLNPs loaded with VAN, showing a mean size of 106.9 ± 1.4 nm and a zeta potential of −16.5 ± 0.93 mV, contributed to a pronounced increase in drug release in an acidified environment compared to controls; as a response to the lipase enzyme, these antibiotic-loaded SLNPs caused double higher growth inhibition of MRSA biofilm for 5 days and a 3.44-fold reduction of bacteria in a skin-infected mice model compared to free drug [ 171 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

Cited by 37 publications

References 98 publications

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

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Advances in Nanostructures for Antimicrobial Therapy

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