Solid Hollow Fiber Cooling Crystallization

Zarkadas, Dimitrios M.; Sirkar, Kamalesh K.

doi:10.1021/ie0401004

Cited by 38 publications

(41 citation statements)

References 39 publications

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“…On the other hand, the smaller the ID the better is the temperature control for cooling crystallization. The smaller the ID the lower is the difference in the temperature between the wall and the centerline leading to a much reduced level of difference in the supersaturation levels at different radial locations (Zarkadas and Sirkar, 2004).…”

Section: Shfcc Module Fabricationmentioning

confidence: 99%

“…To overcome most of the deficiencies of previous techniques, we have adapted the solid hollow fiber cooling crystallization (SHFCC) method developed earlier (Zarkadas and Sirkar, 2004). In the SHFCC, a solution of the drug to be crystallized flows in the bore of a solid hollow fine fiber whose wall is impervious; a cold liquid flows on the shell side of this hollow fine fiber in a countercurrent direction setting up a rapid and highly efficient heat exchange (Song et al, 2010) leading to cooling-based crystallization of the solute in the lumen-side liquid.…”

Section: Introductionmentioning

confidence: 99%

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Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization

Chen

Singh

Sirkar

et al. 2016

International Journal of Pharmaceutics

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A facile way to continuously coat drug crystals with a polymer is needed in controlled drug release. Conventional polymer coating methods have disadvantages: high energy consumption, low productivity, batch processing. A novel method for continuous polymer coating of drug crystals based on solid hollow fiber cooling crystallization (SHFCC) is introduced here. The drug acting as the host particle and the polymer for coating are Griseofulvin (GF) and Eudragit RL100, respectively. The polymer's cloud point temperature in its acetone solution was determined by UV spectrophotometry. An acetone solution of the polymer containing the drug in solution as well as undissolved drug crystals in suspension were pumped through the tube side of the SHFCC device; a cold liquid was circulated in the shell side to rapidly cool down the feed solution-suspension in the hollow-fiber lumen. The polymer precipitated from the solution and coated the suspended crystals due to rapid temperature reduction and heterogeneous nucleation; crystals formed from the solution were also coated by the polymer. Characterizations by scanning electron microscopy, thermogravimetric analysis, laser diffraction spectroscopy, X-ray diffraction, Raman spectroscopy, and dissolution tests show that a uniformly coated, free-flowing drug/product can be obtained under appropriate operating conditions without losing the drug's pharmaceutical properties and controlled release characteristics.

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Section: Shfcc Module Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization

Chen

Singh

Sirkar

et al. 2016

International Journal of Pharmaceutics

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“…2.3 [67,84]. For instance, Zarkadas et al [79] used membrane cooling crystallisation to crystallise potassium nitrate in a solid hollow fibre crystalliser in a stirred tank. The crystals obtained were 3-4 times smaller in average crystal size compared to crystals produced by conventional cooling crystallisation approach.…”

Section: Membrane Crystallisationmentioning

confidence: 99%

“…Membrane crystallisation offers several advantages over traditional crystallisation technologies by being less energy intensive [61,83,94]. This process also provides effective means for crystal size control [79,[95][96][97], in addition to attaining heterogeneous nucleation, thus reducing the levels of supersaturation needed for crystallisation by providing a nucleation site [67,70,91,98]. Another important advantage found with membrane crystallisation is the scalability of the systems [99].…”

Section: Membrane Crystallisationmentioning

confidence: 99%

“…Schematic representation of different membrane crystallisation solidification processes[67]. The dilution and reaction supersaturation modes correspond to antisolvent crystallisation and precipitation processes respectively.There are generally five different membrane crystallisation approaches for the formation of solid material[67,68,[71][72][73][74][75][76][77][78][79]. Currently, membrane crystallisation has either been used as a means for creating supersaturation and nucleation before the liquid of interested is transferred into a crystalliser (hybrid membrane crystallisation)[66,67,80], or where nucleation and crystal growth occurs near the surface of a membrane unit (integrated membrane crystallisation)[67,[81][82][83].…”

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Novel percrystallisation process by inorganic carbon membranes

Madsen¹

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This thesis demonstrates, for the first time, the use of sucrose derived inorganic membranes for crystallisation. In addition, this thesis also shows, for the first time, a process where solvents and solutes are separated in a single step, contrary to polymeric membrane crystallisation which requires two extra steps downstream to filter and dry crystals. There are two further major aspects of this first demonstration as a contribution to the body knowledge in the area of crystallisation. The third novelty is the demonstration of the percrystalisation transport mechanism, occurring as the solution permeates through the membrane where a wet thin film is formed on the permeate face of the membrane. The wet thin film forms a solid-liquid-vapour interface. At this interface, effective evaporation of the solvent occurs under a vacuum, resulting in the crystallisation of the solute on the membrane surface. Hence, a unique single step separation process occurs as the solvent evaporates and concomitantly the crystallised solute is continuously ejected from the surface of the membranes. This novel process is called percrystallisation reflecting the single step permeation and crystallisation. Additionally, this process is able to produce essentially pure water at rates comparable to reverse osmosis. This is possible, even at a concentration that far exceeds the capabilities of reverse osmosis. Further, high production crystallised solute rates are achieved as one metre square of membrane can deliver crystallised NaCl fluxes of up to 48,000 kg m-2 per year. The fourth additional demonstration is related to morphology of the membrane and process operations in affecting crystal formation. For instance, by varying carbonisation temperature and feed temperature or vacuum pressure, it is possible to tune the crystallite size and particle size state of the treated solute. Indeed this thesis demonstrates how sodium chloride particles are produced with a much smaller and narrower particle size distribution compared to conventional methods. Likewise, changes in the carbon content of the membrane, feed temperature, and feed concentration are able to produce nickel sulphate with different hydration states. This thesis further shows examples how versatile membrane percrystallisation can be for processing several types of solutes such as paracetamol (a pharmaceutical analgesic), Vitamin C (food and pharmaceutical compound) and several nitrate and sulphate salts for hydrometallurgy applications. This thesis opens a window of research opportunities to effectively crystallise compounds of interest for a wide spectrum of industries.

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