Solid heterogeneous phantoms for multimodal ultrasound and diffuse optical imaging: an outcome of the SOLUS project for standardization

Sieno, Laura Di; Cubeddu, Rinaldo; Sportouche, H.; Savery, David; Sekar, Sanathana Konugolu Venkata; Rosinski, Bogdan; Farina, Andrea; Ferocino, Edoardo; Lanka, Pranav; Taroni, Paola; Pifferi, Antonio; Mora, Alberto Dalla

doi:10.1117/12.2526645

Cited by 4 publications

(4 citation statements)

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“…225 Standardization of DOI systems for clinical translation is ongoing, e.g., through a project to characterize DOI systems using phantoms, 242 particularly for breast cancer detection. 243 5.3 Spectroscopic OCT…”

Section: Limitationsmentioning

confidence: 99%

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

et al. 2022

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. Significance: Measurement and imaging of hemoglobin oxygenation are used extensively in the detection and diagnosis of disease; however, the applied instruments vary widely in their depth of imaging, spatiotemporal resolution, sensitivity, accuracy, complexity, physical size, and cost. The wide variation in available instrumentation can make it challenging for end users to select the appropriate tools for their application and to understand the relative limitations of different methods. Aim: We aim to provide a systematic overview of the field of hemoglobin imaging and sensing. Approach: We reviewed the sensing and imaging methods used to analyze hemoglobin oxygenation, including pulse oximetry, spectral reflectance imaging, diffuse optical imaging, spectroscopic optical coherence tomography, photoacoustic imaging, and diffuse correlation spectroscopy. Results: We compared and contrasted the ability of different methods to determine hemoglobin biomarkers such as oxygenation while considering factors that influence their practical application. Conclusions: We highlight key limitations in the current state-of-the-art and make suggestions for routes to advance the clinical use and interpretation of hemoglobin oxygenation information.

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Section: Limitationsmentioning

confidence: 99%

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

et al. 2022

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“…Joint US-DOT heterogeneous phantoms were specifically developed by the SOLUS consortium for this study and for future experimental validation of the multimodal probe. Their detailed description can be found in [ 48 ]. Solid materials were preferred to obtain stable and durable phantoms.…”

Section: Image Reconstruction In Diffuse Optical Tomographymentioning

confidence: 99%

“…Both bulk and perturbation phantoms were fabricated with different optical properties by adding different calibrated (at 690 nm wavelength) quantities of titanium (IV) oxide powder (Sigma Aldrich, USA) as a scattering element and toner powder (Infotec, Toner Black 46/l) as absorber, thus permitting an almost flat absorption coefficient over a broad spectral range. It is worth noting that the recipe was validated demonstrating the independence between acoustic properties and the concentration of absorbers and scatterers (in the concentrations of interest for this study) [ 48 ]. Here, a bulk phantom with (nominally) μ s ′ = 1 mm −1 and μ a = 0.01 mm −1 was used, with a top slice of 5 mm thickness (featuring same optical properties as the bulk) covering a 1 cm 3 perturbation with (nominally) μ s ′ = 1 mm −1 and μ a = 0.005, 0.01, 0.02, 0.04 or 0.06 mm −1 .…”

Section: Image Reconstruction In Diffuse Optical Tomographymentioning

confidence: 99%

Enhanced diffuse optical tomographic reconstruction using concurrent ultrasound information

Sciacca

Sieno

Farina

et al. 2021

Phil. Trans. R. Soc. A.

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Multimodal imaging is an active branch of research as it has the potential to improve common medical imaging techniques. Diffuse optical tomography (DOT) is an example of a low resolution, functional imaging modality that typically has very low resolution due to the ill-posedness of its underlying inverse problem. Combining the functional information of DOT with a high resolution structural imaging modality has been studied widely. In particular, the combination of DOT with ultrasound (US) could serve as a useful tool for clinicians for the formulation of accurate diagnosis of breast lesions. In this paper, we propose a novel method for US-guided DOT reconstruction using a portable time-domain measurement system. B-mode US imaging is used to retrieve morphological information on the probed tissues by means of a semi-automatical segmentation procedure based on active contour fitting. A two-dimensional to three-dimensional extrapolation procedure, based on the concept of distance transform, is then applied to generate a three-dimensional edge-weighting prior for the regularization of DOT. The reconstruction procedure has been tested on experimental data obtained on specifically designed dual-modality silicon phantoms. Results show a substantial quantification improvement upon the application of the implemented technique. This article is part of the theme issue ‘Synergistic tomographic image reconstruction: part 2’.

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“…The measurement of tissue chromophore performed by broadband TD-DOS could complement other technologies like an ultrasound for morphological information, elastography to estimate tissue stiffness, diffuse correlation spectroscopy to monitor blood flow. Some exploration is already under progress in this direction [36,187,188,191]. A further push is foreseen in the near future to bring in a multimodal broadband TD-DOS, where the specificity of TD-DOS will be combined with complementary information from other modalities.…”

Section: Future Outlookmentioning

confidence: 99%

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

et al. 2019

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This review presents recent developments and a wide overview of broadband time domain diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration, advanced instrumentation, methods of analysis, applications covering multiple domains (tissue chromophore, in vivo studies, food, wood, pharmaceutical industry) are elaborated. The key role of standardization and recent studies in that direction are discussed. Towards the end, a brief outlook is presented on the current status and future trends in broadband TD-DOS.

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Solid heterogeneous phantoms for multimodal ultrasound and diffuse optical imaging: an outcome of the SOLUS project for standardization

Abstract: Solid heterogeneous phantoms for multimodal ultrasound and diffuse optical imaging: an outcome of the SOLUS project for standardization," Proc.

Cited by 4 publications

References 10 publications

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

Enhanced diffuse optical tomographic reconstruction using concurrent ultrasound information

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

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