Solid facial edema preceding a diagnosis of retro-orbital B-cell lymphoma

Dragan, Laryssa; Baron, Joseph M.; Stern, Scott; Shaw, James C.

doi:10.1016/s0190-9622(00)90258-5

Cited by 17 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review of the literature revealed 17 cases of facial edema as clinical manifestations of primary cutaneous lymphoma or as accompanying lesions in non‐cutaneous lymphoma in the head and neck area (Table ) . The reports included 11 cases of primary cutaneous lymphoma presenting as facial swelling and six cases with non‐cutaneous lymphoma of the head and neck with accompanying facial swelling.…”

Section: Discussionmentioning

confidence: 99%

Facial swelling: an atypical presentation of cutaneous lymphoma

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Facial swelling: an atypical presentation of cutaneous lymphoma

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Since the lymphatic system controls important immunological functions, it is clear that, whatever the cause, inadequate lymph drainage of a given region makes it an immunologically vulnerable area, 1,2 i.e. a privileged site for a subsequent development of immunocompetencerelated diseases, such as tumours, infections, and immune disorders [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] (Table 2).…”

Section: Regional Chronic Lymphoedemamentioning

confidence: 99%

“…Paradigmatic examples are the case of a basal cell carcinoma and KS both appearing on the same immunocompromised leg, 3 the report of more than 20 basal cell carcinomas on a leg after recurrent erysipelas and chronic lymphoedema, 5 two cases of non-Hodgkin's lymphomas initially confined to lymphoedematous limbs, which then progressed centripetally (as occurs in KS), 8,9 the observation of chronic facial lymphoedema preceding the onset of retro-orbital B-cell lymphoma, 10 and the appearance of cutaneous metastases in a lymphoedematous leg from a follicular centre cell lymphoma. 11…”

Section: Tumoursmentioning

confidence: 99%

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Ruocco¹,

Brunetti

Puca

et al. 2009

Acad Dermatol Venereol

206

275

View full text Add to dashboard Cite

Systemic immunodeficiency is known to facilitate the onset of opportunistic infections, tumours and immune disorders in any district of the body. There are clinical events, such as chronic lymphoedema, herpetic infections, vaccinations and heterogeneous physical injuries which can selectively damage and immunologically mark the cutaneous district they act upon. After the causing event has disappeared, the affected district may appear clinically normal, but its immune behaviour is often compromised forever. An immunocompromised district becomes a site which is particularly susceptible to subsequent outbreaks of opportunistic infections, tumours and immune disorders confined to the district itself. In this review, there is an ample case-report collection of opportunistic disorders (infectious, neoplastic, immune) which appeared in immunocompromised districts. The cases have been grouped according to the clinical settings responsible for the local immune imbalance: regional chronic lymphoedema; herpes-infected sites, which feature the well-known Wolf's isotopic response; and otherwise damaged areas, comprising sites of vaccination, ionizing or UV radiation, thermal burns and traumas. Whatever the immunocompromising factor, a common denominator which facilitates the occurrence of tumours, infections and dysimmune reactions in an immunocompromised district may reside in locally hampered lymph drainage and/or locally altered neuromediator signalling. In fact, any obstacle to the normal trafficking of immunocompetent cells through lymphatic channels or any interference with the signals that the neuropeptides and neurotransmitters released by peripheral nerves send to cell membrane receptors of immunocompetent cells, can significantly alter the local immune response, thus paving the way for heterogeneous opportunistic disorders in the immunocompromised district.

show abstract

“…Idiopathic orbital inflammation [78,79] Lupus erythematosus [41,43,47,48] Cold urticaria [49] Melkersson-Rosenthal syndrome [54,55,80,81] Scleredema adultorum of Buschke [58] Allergic eosinophilic gastroenteritis [53] Relapsing polychondritis [50] Orofacial granulomatosis [82] Lymphoma [83] Polyarteritis nodosa [56] Kaposi's sarcoma [84] Protein-losing enteropathy [85] Superior vena cava syndrome [86] Type B Niemann-Pick disease [87] Esthesioneuroblastoma [88] disorder causing periorbital edema in an ophthalmology setting, we performed a retrospective case series at the University of Iowa Hospitals and Clinics Oculoplastics clinic from 2009-2011. Forty patients were referred with the chief complaint of periorbital edema.…”

Section: Retrospective Case Reviewmentioning

confidence: 99%