Solid Dispersions for Oral Administration: An Overview of the Methods for their Preparation

Abstract

Oral drug delivery remains the most physiological and therefore the most preferred, simplest and easiest administration route. Nevertheless, a multitude of potentially clinically important drugs will not reach the market or achieve their full potential unless their oral bioavailability is improved by formulation. The aim of this review is to present an overview of properties, formulation, excipients and characterization of solid dispersions corresponding to one of the different formulation strategies for design and development of poorly soluble drugs. This work will review and compare in detail the evolution of solid dispersions focused on the different methods of formulation and production of solid dispersions, their stability, their release properties, their pharmacokinetics and methods for their physicochemical characterization.

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs

“…Techniques used for characterization are can be thermal methods, spectroscopic methods, microscopic methods, microthermal analysis, macroscopic techniques, etc. 88 Their significance and characteristic features are listed in Table 7.…”

Physicochemical and dissolution properties of ezetimibe–aspirin binary system in development of fixed-dose combinations

“…Most common method utilised to prepare solid dispersion is fusion method [26][27][28]. However, thermostability of ingredients is basic condition of using this method [29].…”

Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization

“…In brief, SD is defined as the dispersion of drug in a matrix at solid state that has been used to improve the solubility of drugs [ 17 ]. The enhancement in solubility can be endorsed to better wettability, reduction in particle size, decrease in agglomeration, modification in the physical state of the drug from crystalline to amorphous and even in dispersion of the drug on a molecular level [ 18 , 19 ]. In addition, sustained release formulations are designed to reduce the dosing frequency and have shown to improve patient compliance and suitability compared with traditional multiple daily dosing regimens [ 20 , 21 ].…”