Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability

Li, Bin; Konecke, Stephanie; Harich, Kim; Wegiel, Lindsay A.; Taylor, Lynne S.; Edgar, Kevin J.

doi:10.1016/j.carbpol.2012.11.073

Cited by 112 publications

(73 citation statements)

References 34 publications

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“…ASD significantly increases water solubility of quercetin in vitro, and its matrix can be modified to regulate the rate and completeness of quercetin release [95]. However, no studies have yet to be performed examining quercetin-containing ASD in cellular or experimental models of bioavailability.…”

Section: Nano-formulationsmentioning

confidence: 98%

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Endogenous and exogenous mediators of quercetin bioavailability

Guo

Bruno

2015

The Journal of Nutritional Biochemistry

205

125

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Section: Nano-formulationsmentioning

confidence: 98%

“…In addition to lipid-based nano-formulations, amorphous solid dispersions (ASD) are another promising delivery strategy for quercetin [95]. ASD significantly increases water solubility of quercetin in vitro, and its matrix can be modified to regulate the rate and completeness of quercetin release [95].…”

Section: Nano-formulationsmentioning

confidence: 99%

Endogenous and exogenous mediators of quercetin bioavailability

Guo

Bruno

2015

The Journal of Nutritional Biochemistry

205

125

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“…However, Q exhibits a poor solubility in aqueous media. 2,3 Previous studies showed that several strategies were used to improve the solubility of Q, such as solid dispersion 3 and complexation with β-cyclodextrin. 4 Co-crystallization is one of methods used to improve the solubility profile of APIs.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization and <i>In Vitro</i> Dissolution Test of Quercetin-Succinic Acid Co-crystals Prepared Using Solvent Evaporation

Setyawan

Oktavia

Farizka

et al. 2017

tjps

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Objectives: Quercetin is one of the flavonoids with a polyhydroxyaromatic structure. Quercetin has been proposed to exhibit a bioWactivity against oxidative stress. However, quercetin has poor solubility in aqueous media. The purpose of this study was to investigate the physicochemical properties and dissolution rates of quercetin-succinic acid co-crystals. Materials and Methods:The quercetin-succinic acid co-crystals were prepared in 1:1 molar ratio using solvent evaporation. X-ray diffraction, differential thermal analysis, infrared spectroscopy, and scanning electron microscopy were performed to determine the physicochemical properties of quercetin-succinic acid co-crystals. Dissolution was studied in medium citrate buffer with 2% SLS for 60 min using USP II (paddle) apparatus at 100 rpm and 37°C. Results: Based on diffractogram, thermogram, infrared spectrum, and microscopic capture, the physicochemical properties of quercetin-succinic acid co-crystals showed difference to those of quercetin. In addition, the in vitro dissolution test showed that the dissolution profile of co-crystals was significantly higher than pure quercetin. Conclusion: This study suggests that the formation of quercetin-succinic acid co-crystals using solvent evaporation enhanced the physicochemical properties and dissolution rate of quercetin.

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“…In particular, polysaccharides have recently been demonstrated to form ASDs that significantly enhance the solubility of natural compounds including ellagic acid, quercetin, curcumin, naringenin, and resveratrol. [97][98][99] These studies suggest that ASDs in nanoparticle form could potentially be very useful in improving bioavailability through improved solubility and transport across physiological barriers.…”

mentioning

confidence: 99%

Natural product-based nanomedicine: recent advances and issues

Watkins¹,

Wu²,

Zhang³

et al. 2015

IJN

157

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Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications.

show abstract

Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability

Cited by 112 publications

References 34 publications

Endogenous and exogenous mediators of quercetin bioavailability

Endogenous and exogenous mediators of quercetin bioavailability

Physicochemical Characterization and <i>In Vitro</i> Dissolution Test of Quercetin-Succinic Acid Co-crystals Prepared Using Solvent Evaporation

Natural product-based nanomedicine: recent advances and issues

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