Endogenous and exogenous mediators of quercetin bioavailability

Guo, Yi; Bruno, Richard S.

doi:10.1016/j.jnutbio.2014.10.008

Cited by 206 publications

(131 citation statements)

References 102 publications

(193 reference statements)

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“…The multiple hydroxyl groups in the molecular structure of quercetin may play crucial roles in its widely demonstrated biological properties such as antioxidant, antiviral, and anticancer activities (Mendoza & Burd, 2011). However, the use of quercetin as a healthpromoting agent has been limited by its poor bioavailability, which is caused by its low water solubility and high instability in neutral and alkaline media as well as in the small intestine, colon, liver, and kidney (Guo & Bruno, 2015). Many studies have proved that quercetin can bind with animal proteins such as bovine serum albumin (Fang et al, 2011), collagen (Yang et al, 2009), and β-casein (Mehranfar et al, 2013), which may promote the solubility, stability, and bioavailability of quercetin.…”

Section: Introductionmentioning

confidence: 99%

Effect of Surface Dielectric Barrier Discharge on the Physiological Activities of Quercetin

Kim¹,

Yong²,

Park³

et al. 2017

The Korean Journal of Food And Nutrition

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In this study, using the surface dielectric barrier discharge (DBD) produced at atmospheric pressure to improve the physiological activities of quercetin was investigated. Quercetin (at 200 ppm) was treated using air DBD with an input power of 250 W. The tyrosinase inhibition effect and total phenolic content of quercetin increased from 38.96 to 91.58% and from 134.53 to 152.93 ppm, respectively, after 20 min of plasma treatment. The antioxidant activity of quercetin treated for 20 min in the lipid models was higher than that of quercetin treated for 0, 5, and 10 min. Furthermore, plasma-treated quercetin exhibited antimicrobial activity against Listeria monocytogenes, Salmonella Typhimurium, and Staphylococcus aureus, whereas activity was not shown in the control. Structural modifications of the quercetin molecule induced by plasma might be responsible for the improvements in its physiological activity. These results indicate that DBD plasma could be used to enhance the physiological activity of quercetin for various applications in food.

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Section: Introductionmentioning

confidence: 99%

Effect of Surface Dielectric Barrier Discharge on the Physiological Activities of Quercetin

Kim¹,

Yong²,

Park³

et al. 2017

The Korean Journal of Food And Nutrition

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“…According to the literature, the increase in the solubility has been reported to be important for the improvement of oral bioavailability and efficacy of quercetin. 10,11 The purpose of this study was to develop the solid dispersion formulation of quercetin to enhance the solubility and dissolution rate. Considering it is advantageous in solid dispersion systems that molecular dispersion of the drug is achieved over carrier matrix, the drug is needed to be homogeneously mixed with the carrier during the preparation of solid dispersion.…”

Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Quercetin-Loaded Solid Dispersion by Solvent Evaporation and Freeze-Drying Method

Park¹,

Song²,

Choi³

2016

Mass Spectrometry Letters

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: We prepared solid dispersion formulations of quercetin to enhance its solubility and dissolution rate. Various quercetinloaded solid dispersion were tested with quercetin, poloxamer 407, and carrier such as hydroxypropyl methyl cellulose (HPMC), polyethylene glycol 8000 (PEG 8000), and polyvinylpyrrolidone K40 (PVP K40) using solvent evaporation and freeze drying methods in terms of both the aqueous solubility and the dissolution rates of quercetin. The solubility of quercetin as its solid dispersion formulations was markedly improved compared with that of quercetin powder. Especially, highest solubility of quercetin was observed when HPMC was used as a carrier. The cumulative dissolution of quercetin within 360 min from solid dispersion composed of quercetin, poloxamer 407, and HPMC was 8.8-fold higher than the dissolution of pure quercetin. The results of powder Xray diffraction (XRD) and scanning electron microscope (SEM) indicated that quercetin transformed from a crystalline to an amorphous form through the solid dispersion formulation process. These results suggest that the solid dispersion formulation of quercetin with poloxamer 407 and HPMC could be a promising option for enhancing the solubility and dissolution rate of quercetin.

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“…Also, QC is metabolized immediately through enzymatic hydrolysis [9] in GIT when administered orally. It is also glucuronidated, sulphated and methylated [8][9][10] . More than 95 % of QC absorbed is metabolized by hepatic metabolism [6,10] and is eliminated from the intestinal cells through an efflux pump mechanism [10] .…”

Section: Research Papermentioning

confidence: 99%

“…More than 95 % of QC absorbed is metabolized by hepatic metabolism [6,10] and is eliminated from the intestinal cells through an efflux pump mechanism [10] . The absolute bioavailability of QC in rats and human after oral administration of aglycone QC are 16 and 44.8 %, respectively [10] .…”

Section: Research Papermentioning

confidence: 99%

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Ramadon¹,

Anwar²,

Harahap³

2017

pharmaceutical-sciences

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Quercetin has been widely used to treat many diseases because of its high antioxidant activity. However, it has low oral bioavailability and penetration through the skin. The aim of this research was to enhance penetration and bioavailability of quercetin using transdermal ethosomal gel. Three ethosomal formulae, E1 (1 %), E2 (1.5 %) and E3 (2 %) with different concentration of quercetin were prepared using thin-film hydration method. Their physical properties were characterized, and then a selected ethosomal formula was incorporated into a gel dosage form. Two gels, one ethosomal and the other non-ethosomal were prepared. In vitro penetration using Franz diffusion cells and bioavailability study in Sprague Dawley male rats were carried out. Results showed that E2 was the chosen formula to be incorporated into the gel dosage form. According to the in vitro penetration study, the diffusion flux of quercetin from the ethosomal and non-ethosomal gels were 343.35±17.69 ng/cm 2 /h and 120.68±11.92 ng/cm 2 /h, respectively (P<0.05). In the bioavailability study, ethosomal gel showed higher maximum concentration (C max ) and area under curve (AUC 0-t ) when compared to non-ethosomal gel and oral suspension. C max from the ethosomal gel, nonethosomal gel, and oral suspension were 413.49±28.64, 189.46±49.68, and 61.92±14.31 ng/ml, respectively (P<0.05). AUC 0-t from the ethosomal gel, non-ethosomal gel, and oral suspension were 4035.15±560.60, 584.87±265.46, and 431.21±239.85, respectively (P<0.05). In conclusion, ethosomal gel could increase penetration and bioavailability of quercetin compared to non-ethosomal gel.

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Endogenous and exogenous mediators of quercetin bioavailability

Cited by 206 publications

References 102 publications

Effect of Surface Dielectric Barrier Discharge on the Physiological Activities of Quercetin

Effect of Surface Dielectric Barrier Discharge on the Physiological Activities of Quercetin

Preparation and Characterization of Quercetin-Loaded Solid Dispersion by Solvent Evaporation and Freeze-Drying Method

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

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