Solid Carcinomas of the Exocrine Pancreas

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

“…2). This desmoplastic reaction (DR) is associated with an abnormal vasculature with numerous circuitous small leaky blood vessels and capillaries (3). The abundant connective tissue is due to manifestation of growth factor production, such as transforming growth factor h (TGFh), by the tumor microenvironment (TME).…”

Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma

“…1). This manifests itself as bands of fibrous stroma surrounding malignant cells and results in a 3-fold increase in collagen compared with the normal pancreas (2)(3)(4).…”

Human pancreatic ribonuclease 1

“…Islets of Langerhans persist in carcinomas of the pancreas in many conditions associated with fibrosis, 26 although we did not expect that some of those islets would express an acinar protein, RNase 1. Islets of Langerhans persist in carcinomas of the pancreas in many conditions associated with fibrosis, 26 although we did not expect that some of those islets would express an acinar protein, RNase 1.…”