Solid Cancer Mortality Associated with Chronic External Radiation Exposure at the French Atomic Energy Commission and Nuclear Fuel Company

Metz-Flamant, Camille; Samson, Eric; Caër-Lorho, Sylvaine; Acker, A.; Laurier, Dominique

doi:10.1667/rr2528.1

Cited by 27 publications

(27 citation statements)

References 103 publications

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“…Leuraud et al: Radioprotection 2017, 52(3), 199-210 This cohort study is the most informative ever conducted in France among nuclear workers. The merging of the CEA-AREVA NC and EDF cohorts into a large national cohort resulted in better statistical precision in radiation risk estimates than in previous analyses (Laurent et al, 2010;Metz-Flamant et al, 2011b. The low percentage of workers lost to follow-up in this cohort reflects the good quality of this study, partly due to the precision of identifying information contained in the companies' personnel files.…”

Section: Analysis Of the Dose-risk Relationshipmentioning

confidence: 93%

“…The French nuclear worker cohort results from the combination of two nuclear worker cohorts implemented in the 1990s, namely the CEA-AREVA NC cohort (Telle-Lamberton et al, 2007;Metz-Flamant et al, 2011b) that included 36 769 workers and the EDF cohort (Rogel et al, 2005;Laurent et al, 2010) that included 22 392 workers. In 2011, these two cohorts were pooled after handling overlapping individuals (Metz-Flamant et al, 2013).…”

Section: Study Populationmentioning

confidence: 99%

“…Dose reconstruction and dosimetric practices were described elsewhere for the CEA-AREVA NC cohort (Telle-Lamberton et al, 2007;Metz-Flamant et al, 2011b) and the EDF cohort (Laurent et al, 2010). Annual exposure to external IR (primarily gamma rays) was calculated for each worker from individual doses recorded in the frame of radiological protection surveillance and centralized in companies' dosimetric registries.…”

Section: Radiation Exposure Datamentioning

confidence: 99%

“…Among workers who complied with the inclusion criteria of this study, 157 workers from CEA were not included in the cohort as they died before 1968. This problem was discussed by Metz-Flamant et al (2011b) who estimated the SMR for all causes of death including those workers on the 1946-2004 period and showed that it was similar to the SMR for the 1968-2004 period in the CEA-AREVA NC cohort. Moreover, this cohort only includes workers hired by the three employers, CEA, AREVA NC or EDF.…”

Section: Strengths and Potential Limitationsmentioning

confidence: 99%

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Mortality in the French cohort of nuclear workers

et al. 2017

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-Populations of nuclear workers are particularly relevant to study health effects of protracted exposures to low doses at low dose-rates of ionizing radiation. In France, a cohort of nuclear workers employed by the Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AREVA Nuclear Cycle (AREVA NC), or Électricité de France (EDF), and badge-monitored for external radiation exposure, has been followed-up for several decades. Annual exposure to penetrating photons was reconstructed for each worker. Standardized mortality ratios were calculated using national mortality rates as the reference. Estimates of radiation dose-mortality associations were obtained using linear excess relative risk models. Mortality of 59 004 workers was followed-up between 1968 and 2004, for an average of 25 years. The mean cumulative photon H p (10) dose was 18.4 mSv in the whole cohort (median value: 2.1 mSv) and 25.7 mSv among exposed workers. At the end of the follow-up, workers were 56 years old on average and 6310 workers had died. A strong healthy worker effect was observed. Estimated dose-risk relationships were consistent with those from other worker studies for all solid cancers and leukaemia excluding chronic lymphocytic leukaemia, but remained associated to a large uncertainty. This cohort is the most informative study ever conducted in France among nuclear workers.

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Section: Analysis Of the Dose-risk Relationshipmentioning

confidence: 93%

Section: Study Populationmentioning

confidence: 99%

Section: Radiation Exposure Datamentioning

confidence: 99%

Section: Strengths and Potential Limitationsmentioning

confidence: 99%

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Mortality in the French cohort of nuclear workers

et al. 2017

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“…The 90% CI of SMR was applied in 2 studies (34,35); this value was difficult to convert to 95% CI for the present meta-analysis, and the calculation of skewed distribution may have reduced the precision. Another source of bias was the combined colorectal SMR in three individual parts of the colon, small intestines and rectum in several studies (17,26,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47), which could increase heterogeneity. Unfortunately, while the type of work-related exposure may be similar, a large-scale study also has significant differences in sensitivity and may have skewed the results of the meta-analysis.…”

Section: Follow-up --------------------------------------------------mentioning

confidence: 99%

Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Gao

Tang

et al. 2018

mol clin onc

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Abstract. Low-dose ionizing radiation (LDIR) may increase the mortality of solid cancers in nuclear industry workers, but only few individual cohort studies exist, and the available reports have low statistical power. The aim of the present study was to focus on solid cancer mortality risk from LDIR in the nuclear industry using standard mortality ratios (SMRs) and 95% confidence intervals. A systematic literature search through the PubMed and Embase databases identified 27 studies relevant to this meta-analysis. There was statistical significance for total, solid and lung cancers, with meta-SMR values of 0.88, 0.80, and 0.89, respectively. There was evidence of stochastic effects by IR, but more definitive conclusions require additional analyses using standardized protocols to determine whether LDIR increases the risk of solid cancer-related mortality.

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Relationship between exposure to ionizing radiation and mesothelioma risk: A systematic review of the scientific literature and meta‐analysis

Visci

Rizzello²,

Zunarelli

et al. 2022

Cancer Medicine

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Malignant mesothelioma is an infrequent neoplasm that usually arises from the lining cells of the pleural and peritoneal cavities. According to the evidence, asbestos is the most significant risk factor of mesothelioma 1,2 ; the cumulative lifetime risk of developing the disease in the absence of exposure to asbestos, has been estimated to be approximately 3 in 10,000. 3 Recent epidemiological studies have focused on additional possible causal factors of mesothelioma, including asbestiform mineral fibers (erionite; fluoroadenine); carbon nanotubes; chronic serous inflammation; and ionizing radiation. 4

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Solid Cancer Mortality Associated with Chronic External Radiation Exposure at the French Atomic Energy Commission and Nuclear Fuel Company

Cited by 27 publications

References 103 publications

Mortality in the French cohort of nuclear workers

Mortality in the French cohort of nuclear workers

Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Relationship between exposure to ionizing radiation and mesothelioma risk: A systematic review of the scientific literature and meta‐analysis

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