Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Qu, Shugen; Gao, Jin; Tang, Bo; Yu, Bo; Shen, Yueping; Yu, Ting

doi:10.3892/mco.2018.1590

Cited by 7 publications

(5 citation statements)

References 56 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous studies indicate that nuclear workers have an increased risk of brain cancer (e.g., Alexander 1991 ; Qu et al 2018 ; Schubauer-Berigan et al 2005 )) although not all studies show this ( Boice et al 2006 ; Dupree-Ellis et al 2000 ; Hunter et al 2013 ; Kreuzer et al 2015 ; Loomis & Wolf 1996 ; Lopez-Abente et al 2001 ). It is unlikely that the size of the nuclear work force would be sufficient to substantially raise brain cancer incidence rates at the state level.…”

Section: Discussionmentioning

confidence: 99%

Brain cancer incidence rates and the presence of nuclear reactors in US states: a hypothesis-generating study

Williamson

Klug

Schwartz

2021

Environ Geochem Health

View full text Add to dashboard Cite

Background The etiology of brain cancer is poorly understood. The only confirmed environmental risk factor is exposure to ionizing radiation. Because nuclear reactors emit ionizing radiation, we examined brain cancer incidence rates in the USA in relation to the presence of nuclear reactors per state. Methods Data on brain cancer incidence rates per state for Whites by sex for three age groups (all ages, 50 and older, and under 50) were obtained from cancer registries. The location, number, and type of nuclear reactor, i.e., power or research reactor, was obtained from public sources. We examined the association between these variables using multivariate linear regression and ANOVA. Results Brain cancer incidence rates were not associated with the number of nuclear power reactors. Conversely, incidence rates per state increased with the number of nuclear research reactors. This was significant for both sexes combined and for males in the ‘all ages’ category (β = 0.08, p = 0.0319 and β = 0.12, p = 0.0277, respectively), and for both sexes combined in the’50 and older’ category (β = 0.18, p = 0.0163). Brain cancer incidence rates for counties with research reactors were significantly higher than the corresponding rates for their states overall (p = 0.0140). These findings were not explicable by known confounders. Conclusions Brain cancer incidence rates are positively associated with the number of nuclear research reactors per state. These findings merit further exploration and suggest new opportunities for research in brain cancer epidemiology.

show abstract

Section: Discussionmentioning

confidence: 99%

Brain cancer incidence rates and the presence of nuclear reactors in US states: a hypothesis-generating study

Williamson

Klug

Schwartz

2021

Environ Geochem Health

View full text Add to dashboard Cite

show abstract

“…Its most significant target is to explore the longer term impacts of bomb-derived radiation on reasons for death and the occurrence of malignancy. The examination has indicated that the danger of solid malignancy and leukemia among atomic specialists is steady with the dosage assessed, even if they get the radiation at low dose rates over numerous years [ 58 ]. The global INWORKS study has shown that in any event, when the combined dose of atomic industry laborers was under 100 mSv and the dose rate was under 10 mGy every year, the danger of solid malignancy is steady based on the dosage assessment [ 59 ].…”

Section: Biological Effects In Nuclear and Radiological Accidentsmentioning

confidence: 99%

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

et al. 2022

View full text Add to dashboard Cite

Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed radiation exposure devices. Direct damage is caused when radiation interacts directly with cellular components. Indirect effects are mainly caused by the generation of reactive oxygen species due to radiolysis of water molecules. Acute and persistent oxidative stress associates to radiation-induced biological damages. Biological impacts of atomic radiation exposure can be deterministic (in a period range a posteriori of the event and because of destructive tissue/organ harm) or stochastic (irregular, for example cell mutation related pathologies and heritable infections). Potential countermeasures according to a specific scenario require considering basic issues, e.g., the type of radiation, people directly affected and first responders, range of doses received and whether the exposure or contamination has affected the total body or is partial. This review focuses on available medical countermeasures (radioprotectors, radiomitigators, radionuclide scavengers), biodosimetry (biological and biophysical techniques that can be quantitatively correlated with the magnitude of the radiation dose received), and strategies to implement the response to an accidental radiation exposure. In the case of large-scale atomic or radiological events, the most ideal choice for triage, dose assessment and victim classification, is the utilization of global biodosimetry networks, in combination with the automation of strategies based on modular platforms.

show abstract

“…1948-1953 1954-1963 1964-1973 1974-1983 1984-1993 1994-2003 2004-2013 1948-1953 1954-1963 1964-1973 1974-1983 1984-1993 1994-2003 1948-1953 1954-1963 1964-1973 1974-1983 1984-1993 1994-2003 Установлены статистически значимые различия в СП смертности от ЗНО и всех опухолей при содержании плутония > 0,50 кБк у мужчин при сравнении с группой < 0,10 кБк. Проведен крупный мета-анализ по изучению влияния профессионального облучения в низких дозах на риск смертности от солидных опухолей [20]. Выявлена небольшая гетерогенность между исследованиями риска смертности от опухолей ЦНС (Р=0,31, I 2 =11,9 %).…”

Section: результаты и обсуждениеunclassified

Incidence and Mortality from Central Nervous System Tumors in the Cohort of Workers Chronically Exposed to Radiation

Moseeva¹,

Azizova²,

Bannikova³

2022

MEDICAL RADIOLOGY AND RADIATION SAFETY

View full text Add to dashboard Cite

Purpose: To analyze incidence and mortality rates of central nervous system (CNS) primary tumors (PT) in the cohort of workers chronically exposed to radiation. Material and methods: Study cohort included 22237 Mayak Production Association workers. Work history data and dose estimates from the “Mayak Worker Dosimetry System 2013” were used. Clinical and epidemiology data were obtained from the “Clinic” database. Crude and age-adjusted (by indirect method) incidence and mortality rates for CNS PT per 100000 person-years were calculated. Standardized incidence and mortality trends were analyzed by Jointpoint 4.0.4. Results: 53 cases and 47 deaths from malignant neoplasms (MN) of brain and spinal cord, cerebral nerve and other parts of CNS (C70–C72 ICD-10 codes) as well as 40 cases and 7 deaths from non-malignant neoplasms (NMN) of brain and other parts of CNS (D-33 ICD-10 code) were identified. CNS MN were more frequent among males (83 %), and CNS NMN were more frequent among females (55 %). Both CNS MN and NMN developed at younger ages among males as compared with females, CNS PT frequency increased with increased attained age. Analysis in relation to calendar period revealed the increasing trend for CNS PT incidence among females only (р=0,008). Effects of chronic occupational radiation exposure on CNS PT incidence and mortality rates were not established either among males or females. Conclusion: Findings should be considered as preliminary and require further studies.

show abstract

Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Cited by 7 publications

References 56 publications

Brain cancer incidence rates and the presence of nuclear reactors in US states: a hypothesis-generating study

Brain cancer incidence rates and the presence of nuclear reactors in US states: a hypothesis-generating study

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

Incidence and Mortality from Central Nervous System Tumors in the Cohort of Workers Chronically Exposed to Radiation

Contact Info

Product

Resources

About