Solicitation behavior in the estrous female rat: A review

Erskine, Mary S.

doi:10.1016/0018-506x(89)90037-8

Cited by 420 publications

(318 citation statements)

References 94 publications

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“…Solicitation, pacing and lordosis in females (Erskine, 1989), and genital grooming, erection, mounting, intromission, and ejaculation in males (Sachs and Meisel, 1988) appear as typical sexual behaviors in rat during puberty, which occurs between postnatal days 30-50 in rat (Ebling and Cronin, 2000). Hormonal and other physiological changes take place in parallel with the behavioral events.…”

Section: Potential Functions Of Tip39mentioning

confidence: 99%

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Dobolyi

Wang

Irwin

et al. 2006

J of Comparative Neurology

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Tuberoinfundibular peptide of 39 residues (TIP39) is a selective agonist of the parathyroid hormone 2 (PTH2) receptor. The topographical distributions of TIP39 and the PTH2 receptor in the brain, described in young male rats, suggested that TIP39 has limbic and endocrine functions. In the present study, we investigated the expression of TIP39 and the PTH2 receptor in male and female rat brain during postnatal development by means of in situ hybridization histochemistry, quantitative RT-PCR and immunocytochemistry. TIP39's distribution and expression levels are similar in young female and male brains. TIP39 mRNA levels peak at postnatal day 14 and subsequently decline both in the subparafascicular area and the medial paralemniscal nucleus, the two major sites where TIP39 is synthesized. A greater developmental decrease in TIP39 expression in males leads to greater levels in older females than older males. The decrease is partially reversed by pre-pubertal but not post-pubertal gonadectomy. TIP39 peptide levels in cell bodies change in parallel with mRNA levels, while TIP39 appears and disappears somewhat later in nerve fibers. In addition, TIP39 peptide levels are also sexually dimorphic in older rats. In contrast, PTH2 receptor expression in the brain does not decrease during puberty and is not sexually dimorphic even in old animals. The appearance of TIP39 during early, and decline during late, postnatal development together with the gender dependent levels in mature animals suggest that TIP39 may play a role in sexual maturation or gender specific functions. Indexing termstuberoinfundibular peptide of 39 residues; parathyroid hormone 2 receptor; TIP39 and PTH2 receptor in situ hybridization and immunocytochemistry and quantitative

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Section: Potential Functions Of Tip39mentioning

confidence: 99%

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Dobolyi

Wang

Irwin

et al. 2006

J of Comparative Neurology

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“…Biochemical and behavioral assessments of female rat sexual behavior appear to be modified by the type of copulatory environment. In a natural or seminatural copulatory environment, in which there is increased space or opportunity for a female to influence the pace of the copulatory series, the female demonstrates more proceptive behaviors and increases the time between discrete copulatory acts (mounts, intromissions, ejaculations; for review see Beach, 1976;Erskine, 1985Erskine, , 1989McClintock & Adler, 1978;McClintock & Anisko, 1982). Biochemical alterations during paced copulation may better represent changes that occur during copulation in a natural setting and during the full repertoire of proceptive and receptive female sexual behaviors.…”

mentioning

confidence: 99%

Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity.

Matuszewich¹,

Lorrain²,

Hull³

2000

Behavioral Neuroscience

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Dopamine (DA) is responsive to hormonal manipulations and has been implicated in the regulation of female rat sexual behavior. In the present studies, extracellular DA levels were assessed in the medial preoptic area (MPOA) of ovariectomized female rats in response to exogenous ovarian hormones and during sexual activity. In female rats primed with a low dose of estradiol benzoate (2 jxg), but not with a higher dose (20 /xg), a 500-/zg progesterone injection increased extraceUular DA and facilitated copulatory behavior. Extracellular DA levels in the MPOA were further augmented during sexual interactions with a male rat in a nonpacing copulatory chamber by either perineal or vaginal stimulation. However, in a pacing chamber, DA efflux did not increase, although the metabolites rose significantly during copulation. Together, these findings suggest that extracellular DA in the MPOA responds to the hormonal state of the female rat and may contribute to her expression of sexual behavior.

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“…Estradiol treatment alone can induce certain aspects of estrous behavior, such as sexual receptivity (e.g. lordosis); however, estradiol followed by progesterone induces the full complement of behaviors that occur during normal estrus, such as ear-wiggling, dart-hopping, and solicitational behavior (Blaustein and Olster, 1989;Erskine, 1989;Tennent et al, 1980;Whalen, 1974).…”

mentioning

confidence: 99%

Progesterone, but Not Progesterone-Independent Activation of Progestin Receptors by a Mating Stimulus, Rapidly Decreases Progestin Receptor Immunoreactivity in Female Rat Brain

Auger

LaRiccia

Moffatt

et al. 2000

Hormones and Behavior

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Recent studies suggest that progestin receptors may be activated in vivo by neurotransmitters in the absence of ligand. More specifically, vaginal-cervical stimulation (VCS) can influence sexual behavior by activating progestin receptors in the absence of progesterone. Another way to test if progestin receptors are influenced by particular stimuli is to examine progestin receptor immunostaining. We report that progestin receptor immunoreactivity is decreased in the forebrain of estradiolprimed ovariectomized (OVX) rats within 1 h after a subcutaneous injection of progesterone, a time by which rapid down-regulation of progestin receptors does not seem to have occurred. In estradiol-primed OVX rats, VCS also decreased progestin receptor immunoreactivity within 1 h in the medial preoptic area, but not in any other area examined. To determine if the decrease in immunoreactivity by VCS was due to adrenal secretions or by ligand-independent activation of progestin receptors, we repeated the experiment in estradiol-primed OVX/adrenalectomized rats. Prior removal of the adrenal glands blocked the rapid decrease in progestin receptor immunoreactivity, even though data from other experiments suggest that progestin receptors are activated by VCS at this time. These studies suggest the possibility that progestin receptors may be affected differentially by progesterone-dependent or by progesterone-independent pathways. This raises the possibility that activation of progestin receptors by these two distinct pathways may lead to different neuronal consequences.

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Solicitation behavior in the estrous female rat: A review

Cited by 420 publications

References 94 publications

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity.

Progesterone, but Not Progesterone-Independent Activation of Progestin Receptors by a Mating Stimulus, Rapidly Decreases Progestin Receptor Immunoreactivity in Female Rat Brain

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