Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

“…BEC enhances the intrinsic ratio of Bax to Bcl-2 by up-regulating Bax and down-regulating Bcl-2 and Bcl-xL expressions. These effects result in activation of Caspase -8, -9 and -3 in cancer cells, indicating that BEC triggers extrinsic and intrinsic apoptotic pathways in cancer cells [6,[30][31][32][33][34][35][36][37].…”

“…Induction of apoptosis in cancer cells or malignant tissues is accepted as an efficient approach for cancer chemotherapy. Figure 3 shows that BEC rapidly kills cancer cells by the characteristic apoptotic pathway of cell shrinkage, condensation of chromatin and nuclear fragmentation [32,38].…”

“…BEC and its individual components solamargine and solasonine kill cancer cells in a dose-dependent manner and, at therapeutic doses, do not affect normal cells [5,32,34].…”

“…Ex Vivo studies have demonstrated that BEC is effecttive against a wide spectrum of human cancers and that BEC is, in a dose dependent manner, selectively killing cancer cells without harming normal cells [11][12][13][14][15][16]32,34,47,[49][50][51][52]. Figure 4 illustrates the specificity of BEC on cancer cells and lack of effect on normal cells.…”

Solanum cernuum Vell: estudo fitoquímico, avaliação das atividades gastroprotetora, antimicrobiana, citotóxica e obtenção do extrato seco por spray dryer

“…Solasonina e solamargina são glicoalcaloides majoritários encontrados em pelo menos 100 espécies desse gênero (BLANKEMEYER et al, 1998). Estudos demonstraram ação citotóxica desses glicoalcaloides em diferentes linhagens de células tumorais humanas (ZHOU et al, 2014;DING et al, 2013;CHAM, CHASE, 2012;PUNJABI et al, 2008;KUO et al, 2000;DAUNTER, CHAM, 1990;CHAM et al, 1987). , 2008;LORENZI, 1992).…”