Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Abstract

ABSTRACT

Intralesion and Curaderm<sup>BEC5</sup> Topical Combination Therapies of Solasodine Rhamnosyl Glycosides Derived from the Eggplant or Devil’s Apple Result in Rapid Removal of Large Skin Cancers. Methods of Treatment Compared

“…Curaderm BEC5 is a topical cream which contains a mixture of solasodine glycosides (BEC) and is very effective for treating nonmelanoma skin cancers. Advantages of treatment of these lesions with Curaderm BEC5 compared with well established surgical interventions and other therapies have previously been reported [1][2][3]19,20,24,28,29,[33][34][35][36][37].…”

“…The treatment time period with topical Curaderm BEC5 to completely eliminate skin cancers varies from days to months depending on size and type of skin tumours. Large nonmelanoma skin cancers can successfully be treated with Curaderm BEC5 and it may take several months of treatment to eliminate these large tumours [1][2][3]19,20,24,28,29,33,[33][34][35][36][37].…”

“…The incidences of nonmelanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have increased more than 300 percent since 1992 [1,2,38]. For malignant melanoma, increased rates of over 500 percent have been reported from 1975 to 2008 [1,39].…”

“…Limitations and costs of current treatments for skin cancers pose many shortfalls and many patients afflicted with these diseases do not seek proper treatment, resulting in increased morbidity and mortality [1,3,40,41].…”

The use of Kuraderm drug in the treatment of basal cell carcinoma of the head and neck

“…В качестве актив-ного действующего вещества препарат содержит гли-коалкалоиды соласонин и соламаргин, получаемые из растений семейства пасленовых, в концентрации 0,005 %. Содержащийся в углеводной части алкалои-дов моносахарид рамноза избирательно связывается с TNFR-1 рецепторами на поверхности опухолевых клеток, повышает уровень белка Bax относительно Bcl-2, что приводит к усилению апоптоза [3][4][5][6][7].…”