Solar Urticaria

Effects of Chloroquine on Release of Mediators from Mast Cells

“…The docu mented efficacy of chloroquine (CQ) in the treatment of solar urticaria, a mast-cell-mediated dermatosis, suggests that CQ may also have an effect on mast cells [7,8], How ever, the interactions of CQ and mast cells have not been examined; the present study was designed to investigate this possibility. Because human dermal mast cells are pre dominantly of the connective-tissue type [9], a highly purified population of rat serosal mast cells, an established model for the study of connective-tissue mast cell physiol ogy, was chosen in this study [10].…”

Solar Urticaria: A Case with Good Therapeutic Response to Cimetidine

“…Occasional therapeutic successes for so lar urticaria have been achieved with the re gimens including H, or conventional antihistamines, such as chlorpheniramine [11], homochlorcyclizine hydrochloride [2,12], hydroxyzine hydrochloride [4], methylbenzyltetrahydrocarboline [5], and antimalarial agents [6]. In general, however, the drug therapy for solar urticaria is not satis factory.…”

“…Although the pathogenetic mechanisms re main unsolved, it is thought that the condi tion is induced by a variety of etiologies and mechanisms [1][2][3][4][5]. Various wavelengths are responsible for the condition, and most of the cases reported in the English literature are induced by an ultraviolet light range [6], while Japanese patients are most frequently sensitive to visible light [7]. Although vari ous drug therapies for solar urticaria have been tried, their effectiveness is disappoint ing [8,9].…”

Lichtdermatosen im Kindesalter

“…Die Lichturtikaria (LU) ist eine seltene urtikarielle Reaktion der Haut, die durch elektromagnetische Strahlung aus dem Sonnenlichtspektrum ausgelöst wird.Die Pathogenese ist unbekannt [8,14,27]. Die LU imponiert durch Juckreiz, Erythemund Quaddelbildung.…”