Solanum torvum, a source of new steroidal saponins

Colmenares, Alida Pérez; Rojas, LB; Mitaine-Offer, Anne Claire; Pouységu, Laurent; Quideau, Stéphane; Paululat, Thomas; Usubillaga, Alfredo; Lacaille-Dubois, MA

doi:10.1055/s-0032-1320981

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“…It is popularly known as 'laranjinha do mato', 'jurubebarana' 2 or 'jurubeba-branca', being used in folk medicine to treat anemia, liver disorders and as digestive as well. 1 Although phytochemical studies on Solanum species resulted in the isolation of a great variety of steroidal alkaloids and glycoalkaloids, 4,5 to the best of our knowledge, the only report found for this species was an unsuccessful search for solasodine in its unripe fruits.…”

Section: Introductionmentioning

confidence: 99%

Caavuranamide, a novel steroidal alkaloid from the ripe fruits of Solanum caavurana Vell. (Solanaceae)

Vaz¹,

Costa²,

Santos³

et al. 2012

J. Braz. Chem. Soc.

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A investigação fitoquímica dos frutos maduros de Solanum caavurana Vell. (Solanaceae) forneceu um novo alcaloide esteroidal do tipo espirosolano, caavuranamida, juntamente com os alcaloides 4-tomatiden-3-ona e 5α-tomatidan-3-ona. Suas estruturas foram elucidadas através de métodos espectroscópicos. As atividades antiproliferativa e antimicrobiana para o extrato etanólico e subfrações provenientes de partição e de extração ácido-base foram investigadas. A caavuranamida apresentou atividade antibacteriana similar ao controle positivo cloranfenicol contra Rhodococcus equi.Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of spectroscopic methods. The antiproliferative and antimicrobial activities for the ethanolic extract, sub-fractions obtained from partition and acid-base treatment were also evaluated. Caavuranamide showed antibacterial activity similar to the chloramphenicol positive control against Rhodococcus equi.

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Section: Introductionmentioning

confidence: 99%