Sol–gel derived silica/polyethylene glycol hybrids as potential oligonucleotide vectors

Kapusuz, Derya

doi:10.1557/jmr.2019.341

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…This method consists of a set of hydrolysis and polycondensation reactions of metal alkoxides that allows the transition of a sol-gel system from a colloidal solution (the 'sol') into a solid 'gel' phase [8]. During this process, a polymer network is formed and the incorporation of a variety of compounds, such as quercetin, is possible [9]. Furthermore, much research has demonstrated that the introduction of polyethylene glycol (PEG) used as an organic additive in the sol-gel methods can protect and change the speed of drug release incorporated into the matrix [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…During this process, a polymer network is formed and the incorporation of a variety of compounds, such as quercetin, is possible [9]. Furthermore, much research has demonstrated that the introduction of polyethylene glycol (PEG) used as an organic additive in the sol-gel methods can protect and change the speed of drug release incorporated into the matrix [9][10][11]. Regarding the antibacterial properties, it was observed that a minimum of 20 μg/mL of quercetin is sufficient for the inhibition of Staphylococcus aureus and Pseudomonas aeruginosa; a minimum of 300 μg/mL for the inhibition of Proteus vulgaris, and a minimum of 400 μg/mL can inhibit Escherichia coli.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol–Gel Route

et al. 2022

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This paper aims to synthesize, via the sol–gel method, a biomaterial usable in the medical field. Here, the silica-PEG-quercetin system was evaluated in relation to the different concentrations of PEG (0, 6, 12, 24, 50 wt%) and quercetin (0, 5, 10, 15 wt%), respectively. In addition, Fourier Transform-Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Kirby–Bauer analyses were performed. FT-IR was used to evaluate the hybrid formation and the influence of both PEG and Quercetin in the hybrid synthesized materials, SEM was used to evaluate the morphological properties, while the Kirby–Bauer test was used to understand the ability of the materials to inhibit the growth of the assayed bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol–Gel Route

et al. 2022

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“…Silica hybrid gels are among the so-called organic modified silica (ORMOSILs). Nowadays, these materials are being used for multiple applications such as the adsorption of metals in water [ 1 , 2 , 3 ], catalyst support [ 4 , 5 , 6 ], support for luminescent compounds [ 7 , 8 , 9 ], anti-corrosive or fungicide coatings [ 10 , 11 , 12 , 13 ], and biomedicine [ 14 , 15 , 16 , 17 , 18 , 19 ]. The key behind the tunability of the properties of these materials is the synergetic effect that generates the coexistence, at a nanometric scale, of an inorganic skeleton with flexible and functional organic constituents [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Silica Hybrid Xerogels Prepared by Co-Condensation of TEOS and ClPhTEOS: A Chemical and Morphological Study

Cruz-Quesada

Espinal‐Viguri²,

López-Ramón³

et al. 2022

Gels

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The search for new materials with improved properties for advanced applications is, nowadays, one of the most relevant and booming fields for scientists due to the environmental and technological needs of our society. Within this demand, hybrid siliceous materials, made out of organic and inorganic species (ORMOSILs), have emerged as an alternative with endless chemical and textural possibilities by incorporating in their structure the properties of inorganic compounds (i.e., mechanical, thermal, and structural stability) in synergy with those of organic compounds (functionality and flexibility), and thus, bestowing the material with unique properties, which allow access to multiple applications. In this work, synthesis using the sol-gel method of a series of new hybrid materials prepared by the co-condensation of tetraethoxysilane (TEOS) and 4-chlorophenyltriethoxysilane (ClPhTEOS) in different molar ratios is described. The aim of the study is not only the preparation of new materials but also their characterization by means of different techniques (FT-IR, 29Si NMR, X-ray Diffraction, and N2/CO2 adsorption, among others) to obtain information on their chemical behavior and porous structure. Understanding how the chemical and textural properties of these materials are modulated with respect to the molar percentage of organic precursor will help to envisage their possible applications: From the most conventional such as catalysis, adsorption, or separation, to the most advanced in nanotechnology such as microelectronics, photoluminescence, non-linear optics, or sensorics.

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“…Sol-gel preparation can be done with a wide variety of precursors, but silica-based carriers are preferred because they are a well-known system, inexpensive, and biodegradable [21]. Moreover, it has also been reported that silica/PEG hybrids allow us to obtain greater elasticity, to avoid particle agglomeration, and to create a network that entraps many kinds of drugs and compounds in only one step [22].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route

et al. 2021

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The aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO2/Fe20 wt% to modulate the release kinetics of the drug from the systems. Fourier-transform infrared (FTIR) spectroscopy was used to study the interactions between different components in the hybrid materials. The release kinetics in a simulated body fluid (SBF) were investigated, and the amount of Fe2+ released was detected via ultraviolet-visible spectroscopy (UV-Vis) after reaction with ortho-phenanthroline. Furthermore, biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated via the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using spectroscopy. Finally, the potential antibacterial properties of seven different materials against two different bacteria—E. coli and S. aureus—were investigated.

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Sol–gel derived silica/polyethylene glycol hybrids as potential oligonucleotide vectors

Abstract: Abstract

Cited by 12 publications

References 46 publications

Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol–Gel Route

Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol–Gel Route

Novel Silica Hybrid Xerogels Prepared by Co-Condensation of TEOS and ClPhTEOS: A Chemical and Morphological Study

Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route

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