Sol-gel coating loaded with inhibitor on ZE21B Mg alloy for improving corrosion resistance and endothelialization aiming at potential cardiovascular application

Li, Weijie; Ya, SU; Liang, Ma; Zhu, Shijie; Zheng, Yufeng; Guan, Shaokang

doi:10.1016/j.colsurfb.2021.111993

Cited by 27 publications

(5 citation statements)

References 54 publications

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“…More research is now focused on how to prepare endothelial cell layers on the surface of cardiovascular devices [ 29 , 30 ]. Li [ 31 ] designed a series of sol–gel coatings loaded with an inhibitor on ZE21B Mg alloy to improve corrosion resistance and endothelialization, aiming at a potential cardiovascular application. The results suggested the potential of a Schiff base inhibitor-loaded sol–gel coating for enhanced corrosion protection and biocompatibility in bioabsorbable cardiovascular implants.…”

Section: Discussionmentioning

confidence: 99%

CD34 Antibody-Coated Biodegradable Fiber Membrane Effectively Corrects Atrial Septal Defect (ASD) by Promoting Endothelialization

Cui

Fan

et al. 2022

Polymers

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Biodegradable materials are a next-generation invention for the treatment of congenital heart diseases. However, the corresponding technology used to develop ideal biomaterials still presents challenges. We previously reported the first biodegradable atrial septal defect (ASD) occluder made of poly-lactic acid (PLLA). Unfortunately, the PLLA occluder had a limited endothelialization effect. In this study, the surface of the occluder membrane was coated with sericin/CD34 antibodies to promote the growth of endothelial cells and the regeneration of defective tissue and enhance the repair of the atrial septal defect. The physicochemical properties of the coat on the surface of the fiber membrane were characterized. The sericin coat successfully covered the fiber surface of the membrane, and the thickness of the membrane increased with the sericin concentration. The swelling rate reached 230%. The microscopic observation of fluorescently labeled CD34 antibodies showed that the antibodies successfully attached to the fiber membrane; the fluorescence intensity of PLLA-SH5 was particularly high. The in vitro experiment showed that the PLLA-SH-CD34 fiber membrane was biocompatible and promoted the adhesion and proliferation of endothelial cells. According to our findings, the PLLA-SH-CD34 membrane provides a theoretical and technical basis for the research and development of novel biodegradable occluders.

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Section: Discussionmentioning

confidence: 99%

CD34 Antibody-Coated Biodegradable Fiber Membrane Effectively Corrects Atrial Septal Defect (ASD) by Promoting Endothelialization

Cui

Fan

et al. 2022

Polymers

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“…The corrosion inhibition ability of amino acids can be attributed to their propensity to form hydrogen bonds with oxides or hydroxides on metal surfaces [ 66 ]. Li et al prepared a sol-gel coating containing the corrosion inhibitor paeonol condensation tyrosine (PCTyr) Schiff base on the surface of ZE21B Mg alloy to improve corrosion resistance and biocompatibility [ 67 ]. The i corr value of PCTyr Schiff base sol-gel (3.64 × 10 −6 A/cm 2 ) was about two orders of magnitude lower than that of the substrate (1.31 × 10 −4 A/cm 2 ) in simulated body fluid (SBF).…”

Section: Bare Sol-gel Coatingsmentioning

confidence: 99%

Advances in the Modification of Silane-Based Sol-Gel Coating to Improve the Corrosion Resistance of Magnesium Alloys

2023

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As the lightest structural materials, magnesium (Mg) alloys play a significant role in vehicle weight reduction, aerospace, military equipment, energy saving, and emission reduction. However, the poor corrosion resistance of Mg alloys has become a bottleneck restricting its wide application. Developing a good surface protective coating can effectively improve the corrosion resistance of Mg alloys. The silane-based sol-gel coating technology has been widely used in the corrosion protection of Mg alloys in recent years due to its advantages of simple process, accessible tailoring of film composition and structure, and excellent corrosion resistance. Whereas the synthesis of sol-gel coatings includes the hydrolysis and dehydration process, which may inherently contain micron or nano defects in the coatings, thereby making it detrimental to the anti-corrosion effect. Therefore, in order to enhance their protection against corrosion, the appropriate modification of sol-gel coatings has become a current research hotspot. This review is based on the modification methods of silane-based sol-gels on the surface of Mg alloys, which are divided into four categories: bare sol-gel, nanoparticles, corrosion inhibitors, and sol-gel-based composite coatings. The modification methods and corrosion protection mechanism are discussed respectively, and the application, development, and research strategies of silane-based sol-gel coatings are included.

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“…Currently, metal-based stents without coating and ceramic-coated stents are used for the treatment of cardiovascular diseases. [17][18][19][20][21][22][23] However, their design and production still make it difficult to achieve the desired availability and product quality.…”

Section: Introductionmentioning

confidence: 99%

In vitro hemocompatibility studies on small-caliber stents for cardiovascular applications

et al. 2023

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Sol-gel coating loaded with inhibitor on ZE21B Mg alloy for improving corrosion resistance and endothelialization aiming at potential cardiovascular application

Cited by 27 publications

References 54 publications

CD34 Antibody-Coated Biodegradable Fiber Membrane Effectively Corrects Atrial Septal Defect (ASD) by Promoting Endothelialization

CD34 Antibody-Coated Biodegradable Fiber Membrane Effectively Corrects Atrial Septal Defect (ASD) by Promoting Endothelialization

Advances in the Modification of Silane-Based Sol-Gel Coating to Improve the Corrosion Resistance of Magnesium Alloys

In vitro hemocompatibility studies on small-caliber stents for cardiovascular applications

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