Software for Bioprinting

Abstract

The bioprinting of heterogeneous organs is a crucial issue. To reach the complexity of such organs, there is a need for highly specialized software that will meet all requirements such as accuracy, complexity, and others. The primary objective of this review is to consider various software tools that are used in bioprinting and to reveal their capabilities. The sub-objective was to consider different approaches for the model creation using these software tools. Related articles on this topic were analyzed. Software tools are classified based on control tools, general computer-aided design (CAD) tools, tools to convert medical data to CAD formats, and a few highly specialized research-project tools. Different geometry representations are considered, and their advantages and disadvantages are considered applicable to heterogeneous volume modeling and bioprinting. The primary factor for the analysis is suitability of the software for heterogeneous volume modeling and bioprinting or multimaterial three-dimensional printing due to the commonality of these technologies. A shortage of specialized suitable software tools is revealed. There is a need to develop a new application area such as computer science for bioprinting which can contribute significantly in future research work.

Establishing a point-of-care additive manufacturing workflow for clinical use

“…For example, Osirix can be employed for research and development purposes, while Materialize Mimics is better suited for clinical use [ 7 , 58 , 59 ]. For further information regarding modeling and segmentation software, Catherine et alprovides a comprehensive overview of both research directed and more clinically geared options [ 60 ].…”

The 3D Bioprinted Scaffolds for Wound Healing

“…According to Pakhomova et al, [128] the software is classified based on control tools, general computer-aided design (CAD), tools used to convert medical data to CAD formats, and only a few specialised research project tools. The process of bioprinting shows three distinct phases.…”

“…Complexity at this stage is related to the specific printing method and the combination of materials (bioink, scaffold, and other additives). Finally, the post-processing phase includes all steps that occur before bioprinted tissue is completely mature and ready to use [128,129].…”

Function Representation for Basic Processes Modeling in 3D Bioprinting

“…Simulation using the Metropolis Monte Carlo method (SIMMMC) is the specialized application for predicting post-printing structure formation in bioprinted constructs, generating 3D models of various bioprinted constructs [2]. The application has been extended for bioprinting purposes, such as modeling and simulation of the development of bioprinted tissue constructs composed of living cells, hydrogels, and cell culture medium.…”

“…The problem of this software is similar to SIMMMC. Surface Evolver was developed to predict, and model directed self-assembly in multicellular systems by examining each individual cell using the finite element method [2,3]. In the field of bioprinting, Surface Evolver can be used to simulate the fusion of spheroids for vessel printing.…”