Soft tissues

doi:10.1016/b978-0-323-06969-4.00012-x

Cited by 2 publications

(4 citation statements)

References 1,577 publications

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“…Analysis of tissue biopsies of GCTs is key to arriving at an ultimate diagnosis because they are associated with a characteristic pathological scheme. Staining of GCTs with H&E shows ill-defined masses consisting of large polygonal to round cells with abundant cytoplasmic granules [ 1 ]. The borders of these neoplasms are often irregular.…”

Section: Discussionmentioning

confidence: 99%

“…The borders of these neoplasms are often irregular. Gross inspection will involve a small, firm, tan-yellow mass, typically about 1 cm along its greatest dimension, and a high likelihood of an ulcerated or eroded surface [ 1 - 3 , 18 ]. Immunohistochemical stains support a diagnosis of GCT.…”

Section: Discussionmentioning

confidence: 99%

“…The origin of the name of the neoplasm known as a granular cell tumor (GCT) becomes evident when microscopic tissue studies of a GCT reveal ample coarse, eosinophilic granules populating the cytoplasms of disorganized sheets of tumor cells. The borders of GCTs are often irregular and may be so poorly defined as to suggest an invasive nature [ 1 ]. However, in most cases, GCTs are benign, with estimates of the proportion of malignant forms ranging from 2 to 4% [ 2 - 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, in most cases, GCTs are benign, with estimates of the proportion of malignant forms ranging from 2 to 4% [ 2 - 4 ]. Documented instances of GCTs most often describe solitary lesions, although sporadic occurrences of GCTs presenting multifocally are estimated to compose 5 to 7% of cases [ 1 - 3 ]. The largest portion of GCTs form in the gastrointestinal tract, followed by the skin as the second-most common site of origin and the respiratory tract as the third-most common site [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Esophageal Granular Cell Tumor: An Uncommon Cause of Dysphagia

Revia¹,

Mandalia²,

Parikh³

et al. 2023

Cureus

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Granular cell tumors (GCTs) are rare, typically benign, solitary neoplasms that can arise throughout the body, with reports of cases in the tongue, esophagus, colon, skin, vulva, and skeletal muscle, among others. Although GCTs are usually asymptomatic, esophageal GCTs can grow large enough to cause dysphagia. When developing the differential diagnosis for dysphagia, a broad consideration includes routine etiologies such as esophageal strictures, eosinophilic esophagitis, carcinoma, webs and rings, achalasia, and motility disorders, but GCTs may not readily come to mind. Due to their scarcity, this case report is presented to raise awareness of esophageal GCTs and emphasize key goals for diagnosing and managing this uncommon yet treatable cause of dysphagia. This case report details the clinical course of a patient presenting with a chief complaint of difficulty swallowing that was found to be caused by a subepithelial esophageal tumor discovered with esophagogastroduodenoscopy (EGD) and endoscopic ultrasound (EUS). Histopathological studies paired with immunohistochemical investigations of a tissue biopsy confirmed the etiology of the offending esophageal mass to be a GCT. The patient's dysphagia resolved after endoscopic mucosal resection of the GCT, and follow-up evaluations have remained negative for recurrence. This case highlights the esophageal GCT as an uncommon source of dysphagia and the need for EGD and EUS evaluations of subepithelial esophageal lesions accompanied by histopathological analysis for a definitive diagnosis of GCT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Esophageal Granular Cell Tumor: An Uncommon Cause of Dysphagia

Revia¹,

Mandalia²,

Parikh³

et al. 2023

Cureus

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Neurofibromatosis and Neoplasms–two Interesting Cases

Dinesh¹,

Reddy²,

Anantharaj³

2016

jemds

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Neurofibromatosis is an inherited disorder with varied systemic manifestations in the soft tissues, nervous system and skin. Cutaneous manifestations include multiple neurofibromas, café-au-lait macules, Lisch nodules and intertriginous freckling. Hematopoietic neoplasms like lymphomas and leukemias have been reported. We report here two interesting neoplasms associated with neurofibromatosis. The first case is a benign chondroid syringoma of the skin, occurring as a collision tumor in synchrony with neurofibroma. The second report is of a case of chronic myeloid leukemia in an adult with neurofibromatosis. Both cases are presented here for their rarity.

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Soft tissues

Cited by 2 publications

References 1,577 publications

Esophageal Granular Cell Tumor: An Uncommon Cause of Dysphagia

Esophageal Granular Cell Tumor: An Uncommon Cause of Dysphagia

Neurofibromatosis and Neoplasms–two Interesting Cases

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