Soft tissue volume alterations after connective tissue grafting at teeth: the subepithelial autologous connective tissue graft <i>versus</i> a porcine collagen matrix – a pre‐clinical volumetric analysis

Schmitt, Christian; Matta, Ragai Edward; Moest, Tobias; Humann, Julia; Gammel, Lisa; Neukam, Friedrich Wilhelm; Schlegel, Karl Andreas

doi:10.1111/jcpe.12547

Cited by 45 publications

(72 citation statements)

References 29 publications

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“…VCMX in contrast does not demonstrate any encapsulation, making it more prone to undergo remodeling processes. A higher shrinkage rate of collagen matrices compared to SCTGs over time has previously been reported [37]. In that particular study, 70% (SCTG) and 99% (collagen matrix) of the augmented volumes were lost during a 10-month healing period.…”

Section: Discussionsupporting

confidence: 56%

Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

et al. 2017

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Section: Discussionsupporting

confidence: 56%

Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

et al. 2017

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“…Collagen matrix (CM) is routinely used as a biocompatible material for soft tissue augmentation. Xenogeneic CM achieved acceptable tissue volume and thickness increases, minimal pain in patients, and no evidence of infections compared to autogenous transplants based on several preclinical and clinical studies (Herford, Akin, Cicciu, Maiorana, & Boyne, ; Schmitt et al, ; Schmitt et al, ; Thoma et al, ; Thoma, Naenni, Benic, Hämmerle, & Jung, ). To improve the high shrinkage of natural noncross‐linked CM (ncl_CM), cross‐linked CM (cl_CM) was proposed, which could maintain a stable tissue volume because enzymatic degradation was controlled, resulting in slower degradation (Herford, Nguyen, Miller, Tandon, & Signorino, ; Huber, Zeltner, Hämmerle, Jung, & Thoma, ; Rothamel et al, ; Thoma et al, ).…”

Section: Introductionmentioning

confidence: 99%

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

Fujioka‐Kobayashi

Ülgür

Katagiri

et al. 2020

J Biomedical Materials Res

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Collagen biomaterials are widely used for soft tissue augmentation. Cross‐linking techniques for collagen matrix (CM) achieve mechanical and volumetric stability; nevertheless, cross‐linking may compromise biocompatibility. The aim of the present study was to investigate two different three‐dimensional (3D) porcine‐derived CMs, noncross‐linked (ncl)_CM and cross‐linked (cl)_CM, for their effects on macrophages (Mφ) and gingival fibroblasts. The effects of the CMs on the cell viability, proliferation, and polarization of Mφ derived from human monocyte THP‐1 cells were assessed. The effects of paracrine factors from Mφ cultured on the CMs were further studied in human gingival fibroblasts (HGF‐1 cells). The spongy layer of ncl_CM was partially resorbed after 1 day of culture. cl_CM maintained increased numbers of viable cells when compared with ncl_CM on day 3 for both THP‐1 and HGF‐1 cells. Higher mRNA levels of M1 markers, including IL‐1 and IL‐6, were found in Mφ cultured on cl_CM, while no significant differences were observed in M2 marker expression levels, including Arg1 and CD206, for cells cultured on both CMs when compared with those of the control. Furthermore, the conditioned medium collected from Mφ cultured on both CMs decreased cell viability. Nevertheless, neither of the CM‐conditioned media influenced the mRNA levels of TGF‐β, COL1a2, and PDGF‐A in HGF‐1 cells when compared with the control media. A comparison showed that cl_CM tended to result in more viable cells than ncl_CM, while cl_CM polarized Mφ toward an M1 phenotype, which was confirmed by the observation of increased mRNA levels of pro‐inflammatory cytokines.

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“…A porcine acellular dermal collagen matrix (CM) has been introduced as an alternative to SCTGs in order to avoid surgical risks and to decrease patient morbidity . These matrices proved their ability to increase soft tissue thickness in preclinical animal studies . In a comparative dog study, a porcine CM has shown similar results as SCTG after a 10‐month follow‐up .…”

Section: Introductionmentioning

confidence: 99%

Soft tissue augmentation applying a collagenated porcine dermal matrix during second stage surgery: A prospective multicenter case series

Fischer

Testori

Wachtel

et al. 2019

Clin Implant Dent Rel Res

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Background The achievement and preservation of an adequate amount of soft tissue around implants is a critical factor for the prognosis of the treatment. Purpose To evaluate the effectiveness of a porcine dermal matrix applied during second stage implant surgery for horizontal soft tissue augmentation and preservation of dimensional stability. Materials and Methods Twenty patients (mean age 50.2 ± 11.9 [SD] years) candidate to implant therapy and requiring soft tissue augmentation were recruited in four centers. Augmentation was performed in 24 cases. A porcine dermal matrix was placed into a buccal split‐thickness pouch during uncovering surgery. Silicone impressions were taken before surgery (T0), 2 weeks later at suture removal (T2), 6 months (T3), and 24 months (T4) post augmentation. Dimensional changes of soft tissue were evaluated using superimposition of digitalized study casts. Results Nineteen patients (23 implants) could be evaluated at 6 months and 13 patients (17 implants) at 24 months. After 6‐month follow‐up, there was a significant dimensional gain respect to baseline, averaging 0.83 ± 0.64 mm (P < .01). This did not change significantly at 24 months (0.77 ± 0.65 mm, P = .19). The gain was >0.5 mm in 65.2% and 64.7% of the cases, respectively. Soft tissue shrinkage averaged 34.2% ± 77.0% from T2 to T3 (P < .01) and did not change thereafter (P = .39). Shrinkage was more consistent in the posterior mandible than in the maxilla, but not significantly (P = .23 at 6‐month and .36 at 24‐month). No adverse events occurred. Conclusion Within the limitations of this prospective case series, the use of a porcine dermal matrix may provide consistent soft tissue augmentation that maintains up to 24‐month follow‐up, although graft shrinkage may occur in the first 6 months, depending on the location of surgery.

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Soft tissue volume alterations after connective tissue grafting at teeth: the subepithelial autologous connective tissue graft versus a porcine collagen matrix – a pre‐clinical volumetric analysis

Abstract: Ten months after soft tissue thickening, the CM is statistically non-inferior to the SCTG in terms of soft tissue volume and thickness increase. Further 3D studies are needed to confirm the data.

Cited by 45 publications

References 29 publications

Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

Soft tissue augmentation applying a collagenated porcine dermal matrix during second stage surgery: A prospective multicenter case series

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