Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

Naenni, Nadja; Bienz, Stefan P.; Benić, Goran I.; Jung, Ronald E.; Hämmerle, Christoph H. F.; Thoma, Daniel S.

doi:10.1007/s00784-017-2210-3

Cited by 25 publications

(16 citation statements)

References 35 publications

(44 reference statements)

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“…These processes led to a decrease of the augmented area between 2 and 6 months after augmentation both for VCMX and autologous connective tissue grafts in a preclinical setting [3]. This is supported by contour measurements, resulting in a volume decrease for VCMX as well as for autogenous connective tissue grafts in a preclinical study [19]. Results from the present study revealed a decrease of the obtained soft tissue amount mainly within the first 8 weeks (roughly 50%).…”

Section: Discussionsupporting

confidence: 82%

Augmentation of soft tissue volume at pontic sites: a comparison between a cross-linked and a non-cross-linked collagen matrix

et al. 2020

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Aim To assess histopathological and histomorphometric outcomes of soft tissue volume augmentation procedures at pontic sites using a volume-stable cross-linked collagen matrix (VCMX) and a non-cross-linked collagen matrix (XCM). Materials and methods In twelve adult beagle dogs, the mandibular premolars and first molar were hemisected and the mesial root extracted. Soft tissue augmentation was randomly performed using VCMX, XCM, or a sham-operated control. Sacrifice was performed after 4, 8, and 26 weeks. Non-decalcified sections were analyzed for histopathologic and histomorphometric measurements at four different levels below the crest (1.5, 2.5, 3.5, and 5.5 mm). Results Group VCMX presented a greater overall amount of soft tissue at all healing time points, more pronounced fibroblast ingrowth, vascularization, and a substantial new collagen deposition. Over time, group XCM demonstrated faster signs of degradation compared with group VCMX. Four weeks after augmentation, group VCMX yielded a higher mean ridge width compared with groups XCM (2.22 mm VCMX, 0.89 mm XCM (at 2.5 mm); 2.05 mm VCMX, 0.80 mm XCM (at 3.5 mm) p < 0.05) and sham (0.59 mm sham (at 1.5 mm); 0.48 mm (at 2.5 mm); 0.44 mm (at 3.5 mm) p < 0.05). After healing periods of 8 and 26 weeks, measurements in group VCMX remained significantly higher compared with group sham both at 8 weeks (levels of 1.5 mm, 2.5 mm and 5.5 mm) and at 26 weeks (levels of 1.5 mm, 3.5 mm and 5.5 mm) (p < 0.05). Conclusion The use of a cross-linked collagen matrix resulted in a greater and more stable ridge width over time compared with control groups. Clinical relevance Soft tissue volume augmentation at pontic sites is more effective when using a cross-linked compared with a non-cross-linked collagen matrix.

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Section: Discussionsupporting

confidence: 82%

Augmentation of soft tissue volume at pontic sites: a comparison between a cross-linked and a non-cross-linked collagen matrix

et al. 2020

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“…The VCMX tested was described in three studies in canines where the focus was on volume gain and volume changes over time [21,35,36]. These studies have shown that gain of thickness of newly formed tissues adjacent to bone and dental implants was observed up to three months, but not so in the long-term, i.e., at six months.…”

Section: Discussionmentioning

confidence: 99%

Tissue Response to a Porous Collagen Matrix Used for Soft Tissue Augmentation

et al. 2019

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A short inflammatory phase and fast ingrowth of blood vessels and mesenchymal cells are essential for tissue integration of a biomaterial. Macrophages play a key role in this process. We investigated invasion of macrophages, blood vessels, and proliferating cells into a highly porous and volume-stable collagen matrix (VCMX) used for soft tissue augmentation around teeth and dental implants. The biomaterial was implanted in submucosal pouches in the canine maxilla, and the tissue response was analyzed at six different time points. Immunohistochemistry was done for proliferating cells (PCNA), macrophages (MAC387), multinucleated giant cells (CD86), and blood vessels (TGM2). Blood rapidly filled the VCMX pores. During the first week, MAC387+ cells populated the VCMX pores, blood vessels and PCNA+ cells invaded the VCMX, and CD86+ scattered cells were observed. At 15 days, MAC387+ cells were scanty, blood vessels had completely invaded the VCMX, the number of proliferating cells peaked, and fibroblasts appeared. At 30 days, MAC387+ were absent, the numbers of proliferating and CD86+ cells had declined, while blood vessel and fibroblast numbers were high. At 90 days, residual VCMX was well-integrated in soft connective tissue. In conclusion, the VCMX elicited a short inflammatory phase followed by rapid tissue integration.

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“…Consequently, the present study focused on assessing soft tissue substitute materials such as VCMX. Several studies have demonstrated the effectiveness of VCMX in various pre‐clinical and clinical scenarios (Thoma et al, 2016, 2020; Zeltner et al, 2017; Huber et al, 2018; Naenni et al, 2018; De Angelis et al, 2021). A systematic comparison of CTG and VCMX for all four implant timing protocols had not been undertaken previously.…”

Section: Discussionmentioning

confidence: 99%

“…The STL files of each group were superimposed over adjacent tooth structures (Naenni et al, 2018). Superimposition and measurement were performed by one investigator, supervised by a senior investigator who was blinded to the treatment groups (Figure 2).…”

Section: Methodsmentioning

confidence: 99%

Dimensional ridge changes in conjunction with four implant timing protocols and two types of soft tissue grafts: A pilot pre‐clinical study

Lee

Shin

Hämmerle

et al. 2022

J Clinic Periodontology

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Aim: To determine the effect of (1) implant placement timing and (2) the type of soft tissue graft in terms of ridge profile changes.Materials and Methods: Four implant treatment modalities were applied in the mesial root areas of the third and fourth mandibular premolars of 10 mongrel dogs alongside connective-tissue graft (CTG) and volume-stable cross-linked collagen matrix (VCMX): immediate, early, and delayed placement (DP), and DP following alveolar ridge preservation (ARP). All dogs were sacrificed 3 months after soft tissue augmentation. Standard Tessellation Language files from designated time points were analysed.Results: Compared with the pre-extraction situation, the median width of the ridge demontstrated a linear increase only in group ARP/CTG (0.07 mm at the 2-mm level), whereas all other groups showed a reduction (between À1.87 and À0.09 mm, p > .05). Groups ARP/CTG (0.17 mm) and DP/CTG (0.05 mm) exhibited a profilometric tissue gain in a set region of interest (p > .05). The net effect of CTG and VCMX ranged from 0.14 to 0.79 mm. Conclusions: Dimensional ridge changes varied between treatment protocols. ARP with CTG led to the smallest difference in ridge profile between the pre-extraction and the study end time point. Both CTG and VCMX enhanced the ridge contour. K E Y W O R D S connective tissue graft, implant placement, tissue remodelling, volume-stable cross-linked collagen matrix Clinical Relevance Scientific rationale for study: Effects of implant placement timing (immediate placement, early placement, and delayed placement [DP] with or without alveolar ridge preservation [ARP]) and soft tissue augmentation types (connective-tissue graft [CTG]; volume-stable cross-linked collagen matrix [VCMX]) have previously been compared only among selected combinations. There has been no previous thorough investigation encompassing the various treatment modalities within a single model.

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Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data

Cited by 25 publications

References 35 publications

Augmentation of soft tissue volume at pontic sites: a comparison between a cross-linked and a non-cross-linked collagen matrix

Augmentation of soft tissue volume at pontic sites: a comparison between a cross-linked and a non-cross-linked collagen matrix

Tissue Response to a Porous Collagen Matrix Used for Soft Tissue Augmentation

Dimensional ridge changes in conjunction with four implant timing protocols and two types of soft tissue grafts: A pilot pre‐clinical study

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