Soft-tissue tumors update: MR imaging features according to the WHO classification

Vilanova, Joan C.; Woertler, Klaus; Narváez, José Antonio; Barceló, Joaquim; Martinez, Salutario; Villalón, Miguel; Miró, Josefina

doi:10.1007/s00330-005-0130-0

Cited by 66 publications

(50 citation statements)

References 44 publications

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“…Regarding the imaging features, it has been noted that ASPSs mainly present as large and well-defined masses, with equal or slight hyperintensity on T1WI and hyperintensity on T2WI compared with the surrounding structures, and frequently occurring vascular signal voids (6). These features of a high signal intensity on T1WI and the presence of vascular signal voids within and around the tumor may represent the typical MRI features of ASPS (6).…”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

Sun

et al. 2016

Oncology Letters

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Abstract. Alveolar soft-part sarcoma (ASPS) is a rare, highly vascular malignant soft-tissue tumor that predominantly affects young adults. The tumor can occur in any bodily region, but is most frequently observed in the lower deep soft tissues of the extremities, and is rarely observed in the upper extremities. The present study reported a case of ASPS of the right deltoid muscle. The patient presented with a 3-year history of a mass on the right shoulder that exhibited rapid growth in the month prior to diagnosis. Computed tomography (CT) and magnetic resonance imaging (MRI) were performed. The lesion mainly demonstrated isointense or mildly hyperintense signals compared with the muscle on the T1-weighted images of the MRI, and heterogeneous high signal intensity on the T2-weighted images. CT enhancement showed a homogeneous enhanced mass. The tumor was resected and submitted for histopathological examination. The diagnosis was verified as ASPS by microscopic examination and immunohistochemical analysis. No distant metastases were noted. No evidence of local tumor recurrence was seen at 6 weeks following the wide surgical excision. The CT scan revealed no metastatic nodules in either lung during the follow-up. ASPS should be considered as a possible diagnosis when a slow-growing, large mass is detected in young adults in the soft tissue of the extremities, with high signal intensity and numerous signal voids on T1-weighted images (T1WI) and T2WI, and strong contrast-enhancement. IntroductionAlveolar soft-part sarcoma (ASPS) is an infrequently encountered type of soft-tissue sarcoma that usually develops in the soft tissues of the extremities. The tumor accounts for <1% of soft-tissue sarcomas and predominantly affects teenagers and young adults (1). ASPS has a high propensity for metastasis and the lungs are the most frequent site of metastasis by the hematogenous route. Although prolonged survival is possible even in patients with metastasis, the long-term disease specific mortality rate is high. The prognosis of ASPS is poor due to the high frequency of metastatic disease. A large study indicated that the median survival time was 3 years if metastatic disease was present at diagnosis and 11 years without metastatic disease at presentation (1,2). ASPS is a rare, aggressive malignancy of uncertain histological origin, with a predisposition towards vascular invasion and distant metastasis. ASPS is most commonly observed in the extremities (1), but most commonly in the lower rather than the upper limbs. A previous study reported that ASPS is most commonly identified in the lower extremities (44%) and is rarely seen in the upper extremities (2).Magnetic resonance imaging (MRI) is the favored imaging modality for evaluation of this lesion due to its excellent soft tissue contrast, multiplanar imaging capability and lack of radiation exposure. Computed tomography (CT) enhancement and CT angiography clearly showed rich blood vessels within and around the tumor. The present study reports a case of ASPS of the right d...

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Section: Discussionmentioning

confidence: 99%

“…These features of a high signal intensity on T1WI and the presence of vascular signal voids within and around the tumor may represent the typical MRI features of ASPS (6). The precise cause of this high signal intensity on T1WI has not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

Sun

et al. 2016

Oncology Letters

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“…Although the role of MRI in evaluating the extent of sarcomas has already been established, its ability in differentiating between benign and malignant lesions and between the various subtypes of sarcoma is still controversial as most soft tissue tumors have nonspecific imaging findings: intermediate SI on T1WI, high SI on T2WI, and heterogeneous enhancement after contrast administration, due to the presence of hemorrhage and necrosis in the tumor [41]. MR imaging features can, however, be of help in the differential diagnosis if lesions have an atypical appearance, e.g., high SI on T1WI and/or low SI on T2WI.…”

Section: Mr Imaging Featuresmentioning

confidence: 99%

Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors

et al. 2009

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“…At MR imaging, they are well-circumscribed masses, isointense to muscle on T1-weighted images and heterogeneously hyperintense on T2-weighted images and show variable enhancement with a gadolinium contrast agent, depending on the degree of necrosis and hemorrhage (65) (Fig 17).…”

Section: Ewing/primitive Neuroectodermal Tumorsmentioning

confidence: 99%

Pediatric Soft-Tissue Tumors and Pseudotumors: MR Imaging Features with Pathologic Correlation

Laffan¹,

Ngan²,

Navarro³

2009

RadioGraphics

117

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Soft-tissue tumors update: MR imaging features according to the WHO classification

Cited by 66 publications

References 44 publications

Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors

Pediatric Soft-Tissue Tumors and Pseudotumors: MR Imaging Features with Pathologic Correlation

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