Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors

Vliet, M. van; Kliffen, Mike; Krestin, Gabriël P.; Dijke, Cornelis F. van

doi:10.1007/s00330-008-1292-3

Cited by 99 publications

(80 citation statements)

References 37 publications

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“…The median tumor size of the maximal lung metastasis was 15 mm (6-41 mm), and the detection rate by CXR was 66.7% (12/18). The time from detection to surgery for lung metastasis was 4.8 m (1-23), number of CT scans after detection of lung metastasis to surgery was 3.1 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and the interval was markedly shortened to 1.6m (1-4.0m).…”

Section: Resultsmentioning

confidence: 99%

“…A retrospective analysis of consecutive 18 patients (synovial sarcoma, 6; liposarcoma, 3; malignant peripheral nerve sheath tumor, 2; leiomyosarcoma, 2; malignant fibrous histiocytoma, 2; alveolar rhabdomyosarcoma, 2; ewing sarcoma, 1) that underwent surgery for lung metastasis due to STS during a 4-year period was performed between August 2006 and October 2010. The subjects included 9 males and 9 females with a mean age of 42.6 ± 8.6 (12 to 67) years.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effective Utilization of Chest X-ray for Follow-up of Metastatic Lung Tumor due to Soft Tissue Sarcoma

Shikada

Yano

Maruyama

et al. 2013

ATCS

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Computed tomography (CT) is widely used for follow-up of lung metastasis in patients due to soft tissue sarcoma (STS), the frequency of chest X-ray (CXR) is obviously reduced. This study verified the current status of diagnostic measures and the efficacy of CXR. A retrospective analysis of 18 patients that underwent surgery for lung metastasis due to STS was performed. The investigation compared the follow-up interval using CT after STS surgery, time from STS surgery to lung metastasis, tumor size of lung metastasis, detection rate with CXR, time from detection to surgery for lung metastasis, number of CT scans and follow-up interval using CT after detection of lung metastasis. The follow-up interval when using CT after STS surgery was 3.5 months (m). Time from STS surgery to lung metastasis was 34.3m. Tumor size of lung metastasis was 15 mm, and the detection rate by CXR was 66.7%. The time from detection to surgery for lung metastasis was 4.8m, the number of CT scans was 3.1, and the interval was markedly shortened to 1.6m. Follow-up should be performed by CXR if the tumor is detected by CXR. CT evaluation is required when the tumor size has increased, and prior to surgery for lung metastasis.Keywords: soft tissue sarcoma, lung metastasis, follow-up size, histological type and grade, and positive surgical margins. [4][5][6][7][8] Imaging of the chest by computed tomography (CT) and chest X-ray (CXR) is recommended regularly for detecting the presence of pulmonary metastasis after curative resection for STS.Computed tomography is widely used for follow-up of lung metastasis in patients with STS. On the other hand, the frequency of CXR is obviously reduced. The effective radiation dose from CXR is estimated to be between 0.02 mSv and 0.1 mSv, which is equivalent to between 2.4 days and 10 days of background radiation. Obviously, the overall radiation dose of CXR is smaller than that of CT. Furthermore, CT may give false positive results in the presence of small lung nodules (<5 mm). 9)Although CXR is a valid and feasible way, CT is performed without CXR.The aim of this study is to elucidate the current status of diagnostic measures for the follow-up of lung metastasis due to STS and the efficacy of CXR.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effective Utilization of Chest X-ray for Follow-up of Metastatic Lung Tumor due to Soft Tissue Sarcoma

Shikada

Yano

Maruyama

et al. 2013

ATCS

View full text Add to dashboard Cite

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“…The tumor accounts for <1% of soft-tissue sarcomas and predominantly affects teenagers and young adults (1). ASPS has a high propensity for metastasis and the lungs are the most frequent site of metastasis by the hematogenous route.…”

Section: Introductionmentioning

confidence: 99%

“…The prognosis of ASPS is poor due to the high frequency of metastatic disease. A large study indicated that the median survival time was 3 years if metastatic disease was present at diagnosis and 11 years without metastatic disease at presentation (1,2). ASPS is a rare, aggressive malignancy of uncertain histological origin, with a predisposition towards vascular invasion and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

Sun

et al. 2016

Oncology Letters

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Abstract. Alveolar soft-part sarcoma (ASPS) is a rare, highly vascular malignant soft-tissue tumor that predominantly affects young adults. The tumor can occur in any bodily region, but is most frequently observed in the lower deep soft tissues of the extremities, and is rarely observed in the upper extremities. The present study reported a case of ASPS of the right deltoid muscle. The patient presented with a 3-year history of a mass on the right shoulder that exhibited rapid growth in the month prior to diagnosis. Computed tomography (CT) and magnetic resonance imaging (MRI) were performed. The lesion mainly demonstrated isointense or mildly hyperintense signals compared with the muscle on the T1-weighted images of the MRI, and heterogeneous high signal intensity on the T2-weighted images. CT enhancement showed a homogeneous enhanced mass. The tumor was resected and submitted for histopathological examination. The diagnosis was verified as ASPS by microscopic examination and immunohistochemical analysis. No distant metastases were noted. No evidence of local tumor recurrence was seen at 6 weeks following the wide surgical excision. The CT scan revealed no metastatic nodules in either lung during the follow-up. ASPS should be considered as a possible diagnosis when a slow-growing, large mass is detected in young adults in the soft tissue of the extremities, with high signal intensity and numerous signal voids on T1-weighted images (T1WI) and T2WI, and strong contrast-enhancement. IntroductionAlveolar soft-part sarcoma (ASPS) is an infrequently encountered type of soft-tissue sarcoma that usually develops in the soft tissues of the extremities. The tumor accounts for <1% of soft-tissue sarcomas and predominantly affects teenagers and young adults (1). ASPS has a high propensity for metastasis and the lungs are the most frequent site of metastasis by the hematogenous route. Although prolonged survival is possible even in patients with metastasis, the long-term disease specific mortality rate is high. The prognosis of ASPS is poor due to the high frequency of metastatic disease. A large study indicated that the median survival time was 3 years if metastatic disease was present at diagnosis and 11 years without metastatic disease at presentation (1,2). ASPS is a rare, aggressive malignancy of uncertain histological origin, with a predisposition towards vascular invasion and distant metastasis. ASPS is most commonly observed in the extremities (1), but most commonly in the lower rather than the upper limbs. A previous study reported that ASPS is most commonly identified in the lower extremities (44%) and is rarely seen in the upper extremities (2).Magnetic resonance imaging (MRI) is the favored imaging modality for evaluation of this lesion due to its excellent soft tissue contrast, multiplanar imaging capability and lack of radiation exposure. Computed tomography (CT) enhancement and CT angiography clearly showed rich blood vessels within and around the tumor. The present study reports a case of ASPS of the right d...

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“…Synovial sarcoma has a slow clinical course and a relatively well-defined margin, and it consists of multilobular septate masses demonstrating heterogeneous signal intensity on T1-and T2-weighted images as well as heterogeneous contrast enhancement. Heterogeneity caused by areas of necrosis, calcification, cysts, and hemorrhage within a tumor can be helpful for suspicion of synovial sarcoma [17]. Undifferentiated pleomorphic sarcoma is the most common type of soft tissue sarcoma in adults, and in those the MR signal intensity is nonspecific, depending on the cellularity and myxoid content of the lesion as well as the presence of hemorrhage, necrosis, and/or calcification [17].…”

Section: Discussionmentioning

confidence: 99%

MRI features of calcifying aponeurotic fibroma in the upper arm: a case report and review of the literature

et al. 2016

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Calcifying aponeurotic fibroma is a rare soft tissue tumor that occurs in the distal extremities of children and adolescents. We report a case of pathologically proven calcifying aponeurotic fibroma in the left upper arm of a 23-year-old female. Radiographs revealed increased soft tissue density with multiple stippled calcifications in the mid-portion of the patient's left upper arm. Magnetic resonance imaging (MRI) showed a well-defined soft tissue mass with low to intermediate signal intensity on T1-weighted images, heterogeneously low signal intensity on T2-weighted images, and heterogeneous enhancement on fat-suppressed, contrast-enhanced T1-weighted images. Histologically, spindle cell proliferation with scattered calcifications and hyalinization was present. Seven years after surgery, there was no evidence of local recurrence. This is the first report of MRI findings of calcifying aponeurotic fibroma in the upper arm. We also summarize the MRI findings of 16 previously reported cases of calcifying aponeurotic fibroma originating in the upper or lower extremities.

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Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors

Cited by 99 publications

References 37 publications

Effective Utilization of Chest X-ray for Follow-up of Metastatic Lung Tumor due to Soft Tissue Sarcoma

Effective Utilization of Chest X-ray for Follow-up of Metastatic Lung Tumor due to Soft Tissue Sarcoma

Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report

MRI features of calcifying aponeurotic fibroma in the upper arm: a case report and review of the literature

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