Soft tissue tuberculosis – An unusual presentation of a common disease

Manicketh, Indu; Panjwani, Poonam; Ravikumar, Gayatri; Mathan, Leo Prince

doi:10.1016/j.ijtb.2017.04.002

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Soft tissue TB occurs mostly in the extremities, and patients present with local masses, swelling, and weakness. Only a small percentage of patients present with constitutional symptoms such as fever and weight loss[ 25 , 26 ]. Most cases of soft tissue TB reported in the literature were diagnosed by histological examination and MTB culture, whereas some were confirmed by rapid PCR.…”

Section: Discussionmentioning

confidence: 99%

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

He¹,

Huang²,

Yi³

et al. 2023

World J Clin Cases

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BACKGROUND Soft tissue tuberculosis is rare and insidious, with most patients presenting with a localized enlarged mass or swelling, which may be factors associated with delayed diagnosis and treatment. In recent years, next-generation sequencing has rapidly evolved and has been successfully applied to numerous areas of basic and clinical research. A literature search revealed that the use of next-generation sequencing in the diagnosis of soft tissue tuberculosis has been rarely reported. CASE SUMMARY A 44-year-old man presented with recurrent swelling and ulcers on the left thigh. Magnetic resonance imaging suggested a soft tissue abscess. The lesion was surgically removed and tissue biopsy and culture were performed; however, no organism growth was detected. Finally, Mycobacterium tuberculosis was confirmed as the pathogen responsible for infection through next-generation sequencing analysis of the surgical specimen. The patient received a standardized anti-tuberculosis treatment and showed clinical improvement. We also performed a literature review on soft tissue tuberculosis using studies published in the past 10 years. CONCLUSION This case highlights the importance of next-generation sequencing for the early diagnosis of soft tissue tuberculosis, which can provide guidance for clinical treatment and improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

He¹,

Huang²,

Yi³

et al. 2023

World J Clin Cases

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“…General symptoms such as fever and weight loss are inconsistent. 14 , 15 Recent cases of soft tissue tuberculosis published in the last 10 years were identified by conducting a search on PubMed ( Table 1 ). We found 17 reported cases in the literature, including 10 males and seven females.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Tuberculous abscess of the popliteal fossa: A case report

Belhassen,

Khlif,

Ferjani

et al. 2023

F1000Res

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Introduction Tuberculosis of the soft tissues is a rare form of extra pulmonary tuberculosis, and isolated localization in the popliteal fossa is particularly exceptional. Atypical clinical presentation can lead to delayed diagnosis and serious complications. Case report We report the case of a 17-year-old patient who was diagnosed with tuberculosis of the popliteal fossa. He presented with a painful inflammatory swelling of the right popliteal fossa associated with a homolateral inguinal lymph node, without knee joint effusion. Standard chest and knee X-rays were normal, while MRI showed an 8 cm well vascularized, partly liquefied mass in the popliteal fossa, developed in contact with the semimembranosus and medial gastrocnemius muscles, associated with a popliteal lymph node without synovial effusion or thickening. Microbiological tests did not isolate any germs. The diagnosis was made on histological examination after biopsy, which revealed a caseous granuloma surrounded by epithelioid cells. The patient was treated with anti-tuberculosis therapy for 9 months. The clinical and radiological regression of the swelling was observed without recurrence at 2 years of follow-up. Conclusion Any soft tissue abscess should raise suspicion of tuberculosis, especially in endemic countries. The importance of histopathological examination should be emphasized to establish the diagnosis in the absence of signs in favor of a primary localization.

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“…It represents 10% of all types of extrapulmonary TB and its presentation is 1-5% of all musculoskeletal TB cases 10,11 . It should be considered in immunocompetent patients 12,13 . The main risk factor is to have a history of TB, which is reported in up to 70-80% of cases 14 .…”

Section: Discussionmentioning

confidence: 99%

Chest wall soft-tissue tuberculosis: A case report

Álvarez-Moran¹,

Ávila-Sánchez

Fernández-Lara³

2020

HGMX

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Chest wall tuberculosis (TB) is a rare condition, making up 1-5% of all musculoskeletal TB cases. We report a case of a 39-year-old woman with a palpable mass on the right hemithorax with a 3-month evolution. The computed tomography scan showed a mass of 4 cm above the pectoralis major muscle. Complete removal of the tumor was performed, which showed caseous material with positive polymerase chain reaction for Mycobacterium tuberculosis. The patient has not presented any symptoms 6 months after a quadruple-based therapy. We emphasize the fact of suspecting this pathology, when soft-tissue masses are found on the chest wall, due to its rare localization.

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Soft tissue tuberculosis – An unusual presentation of a common disease

Cited by 4 publications

References 2 publications

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

Case Report: Tuberculous abscess of the popliteal fossa: A case report

Chest wall soft-tissue tuberculosis: A case report

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