Soft Tissue Anaplastic Large T-Cell Lymphoma Associated with a Metallic Orthopedic Implant: Case Report and Review of the Current Literature

Invited Discussion on: “What is the Evidence of Lymphoma in Patients with Prostheses Other Than Breast Implants?”

“…The presence of the dental implants in the site of primary lesion formation allowed the authors to search for similarities with BIA-ALCL and compare their case with a previously reported orthopedic case of CD30? ALK-negative T cell lymphoma in a patient with a tibial implant [3]. Since 2015, there have been no other reports on mucosal lymphomas or LPDs associated with dental implants, despite the fact that according to the results of a survey, conducted by the American Association of the Oral and Maxillofacial surgeons, 500,000 people undergo dental implant procedures each year.…”

“…To the authors best knowledge, up until 2010 and ever since there has been no medical reports on cases of T cell lymphomas arising in the areas of orthopedic prothesis installment. However, in 2010, a case report by Bharath Palraj was published in the Journal of Foot and Ankle Surgery [3]. A case of a 77-year-old man presented with a 2-week history of pain and erythema at the medial aspect of the distal portion of his right leg, adjacent to an old wound where 7 years earlier he had undergone placement of a stainless steel plate and screws for repair of a spiral fracture of the tibia.…”

Differenzialdiagnostische Erwägungen zur Periimplantitis

“…Die Pathogenese ist weiterhin unklar. Chronische Entzündungsvorgänge gelten als mögliche Ursache [33]. Generell gilt eine Immunsuppression als möglicher Risikofaktor [34].…”

Finding Consensus After Two Decades of Breast Implant-Associated Anaplastic Large Cell Lymphoma

“…27 Localized ALK-CD30+ ALCL has been described in limited case reports arising around a tibial metallic plate, dental implant, a shoulder repair, and a textured gluteal implant. [28][29][30][31] Interestingly, one case of an implant-associated ALK-CD30+ ALCL after bariatric surgery was reported, and the device was fabricated from elastopolymers similar to breast implants (Lap-Band AP; Allergan). 32 A case described by Engberg et al, presented with a unique skin ALCL in a single plague directly over an implanted chemotherapy port (product #0655640, Bard Access Systems) containing silicone and polyurethane.…”