Soft poly(N-vinylcaprolactam) nanogels surface-decorated with AuNPs. Response to temperature, light, and RF-field

Siirilä, Joonas; Karesoja, Mikko; Pulkkinen, Petri; Malho, Jani Markus; Tenhu, Heikki

doi:10.1016/j.eurpolymj.2019.03.010

Cited by 21 publications

(22 citation statements)

References 62 publications

(118 reference statements)

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“…It is known that in aqueous solutions of linear PNVCL, hydrophobic pockets (partly folded regimes) exist inside the coil even at room temperature 47 , 52 and that their number is elevated in PNVCL gel particles. 16 Upon heating, the emission intensity from PNVCL–PA nanogel decreased, indicating the diffusion of the probe out from the particles. This was not due to the precipitation of the nanogels, and therefore it was attributed to gel collapse.…”

Section: Resultsmentioning

confidence: 99%

“…PNVCL nanogels were synthesized via precipitation polymerization according to a literature protocol. 16 The synthesis is presented in Figure 2 . In a typical reaction, the monomers NVCL (1.880 g, 13.5 mmol), methacrylic acid (MAA, 20 mg, 0.23 mmol), the crosslinker BAC (20 mg, 0.077 mol), and the surfactant sodium dodecyl sulfate (SDS, 50 mg, 0.0173 mmol) together with a base NaHCO 3 (50 mg) were dissolved in 196 g of water.…”

Section: Methodsmentioning

confidence: 99%

“…The synthesis of surface-functionalized PNVCL nanogels can be performed through a semibatch precipitation polymerization, which typically produces core–shell particles. 14 Previously, this method has been applied to the synthesis of PNVCL nanogels using glycidyl methacrylate, GMA, 15 or propargyl acrylate, PA, 16 as comonomers. The GMA or PA groups, which reside on the surface of the nanogels can be further functionalized through postpolymerization reactions.…”

Section: Introductionmentioning

confidence: 99%

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Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(N-Vinylcaprolactam) Nanogels

et al. 2020

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Soft nanoparticles are interesting materials due to their size, deformability, and ability to host guest molecules. Surface properties play an essential role in determining the fate of the particles in biological medium, and coating of the nanoparticles (and polymers) with carbohydrates has been found to be an efficient strategy for increasing their biocompatibility and fine-tuning other important properties such as aqueous solubility. In this work, soft nanogels of poly( N -vinylcaprolactam), PNVCL, were surface-functionalized with different glucose and maltose ligands, and the colloidal properties of the gels were analyzed. The PNVCL nanogels were first prepared via semibatch precipitation polymerization, where a comonomer, propargyl acrylate (PA), was added after preparticle formation. The aim was to synthesize “clickable” nanogels with alkyne groups on their surfaces. The nanogels were then functionalized with two separate azido-glucosides and azido-maltosides (containing different linkers) through a copper-catalyzed azide–alkyne cycloaddition (CuAAc) click reaction. The glucose and maltose bearing nanogels were thermoresponsive and shrank upon heating. Compared to the PNVCL–PA nanogel, the carbohydrate bearing ones were larger, more hydrophilic, had volume phase transitions at higher temperatures, and were more stable against salt-induced precipitation. In addition to investigating the colloidal properties of the nanogels, the carbohydrate recognition was addressed by studying the interactions with a model lectin, concanavalin A (Con A). The binding efficiency was not affected by the temperature, which indicates that the carbohydrate moieties are located on the gel surfaces, and are capable of interacting with other biomolecules independent of temperature. Thus, the synthesis produces nanogels, which have surface functions capable of biorelevant interactions and a thermoresponsive structure. These types of particles can be used for drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(N-Vinylcaprolactam) Nanogels

et al. 2020

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“…Nanogels have been widely explored as cargo carriers. The release of cargo from nanogels can be triggered with different stimuli, including redox potential [460,461], pH changes [462,463], salt concentration [464], US [29], temperature [465], or light [466][467][468]. Also, it is possible to render nanogels responsive to specific stimuli, such as magnetic fields [469], by decorating nanogels with magnetic NPs.…”

Section: Nanogelsmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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“…The mechanistic action of MTRSI-NGs in the body occurs by three following successions: first, magnetically conducting MTRSI-NGs to targeted tissue, second, the magnet leads to the increasing temperature of Fe 3 O 4 and then heat transfer to thermoresponsive nanogels to LCST until to protein release, third wipe out body from MTRSI-NGs (He et al 2013;Smith et al 2021;Uhrich et al 1999).Cytotoxicity of PNVCL was investigated by Han et al The results showed that PNVCL did not show toxicity with short-term cell exposure. PNVCL withstand increases in temperature, while others change from twophase to single-phase by increasing temperature (Dinari et al 2021;Fernández-Quiroz et al 2015;Siirilä et al 2019;Vihola et al 2005).Temperature responsive polymers present an excellent hydrophobic-hydrophilic balance in their structure. The slight change in temperature near the cloud point makes the chains collapse.…”

Section: Introductionmentioning

confidence: 99%

Magnetic dual-responsive semi-IPN nanogels based on chitosan/PNVCL and study on BSA release behavior

et al. 2021

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Magnetic thermoresponsive nanogels present a promising new approach for targeted drug delivery. In the present study, bovine serum albumin (BSA) loaded thermo-responsive magnetic semi-IPN nanogels (MTRSI-NGs) were developed. At first poly(N-vinyl caprolactam) (PNVCL) was synthesized by free radical polymerization and then MTRSI-NGs were prepared by crosslinking chitosan in presence of chitosan and Fe 3 O 4 . The formation of MTRSI-NGs has been confirmed by FTIR, and the average molecular weight of PNVCL was determined by GPC analysis. Rheological and turbidimetry analysis were used to determine lower critical solution temperature (LCST) of PNVCL and magnetic thermo-responsive nanogels (MTRSI-NGs) around 32 and 37 °C, respectively. FE-SEM analysis showed particle size at less than 20 nm in the dried state. Dynamic light scattering determined particle size at about 30 nm in a swelling state. The analysis of release behavior showed that the BSA release ratio at 40 °C was faster than 25 °C. The pH release behavior was evaluated at pH 5.5 and 7.4 and showed that the drug release rate at pH 5.5 was more rapid than pH 7.4. The results show MTRSI-NGs are applicable to protein targeted delivery by thermosensitive targeted drug delivery systems. KeywordsMagnetic thermoresponsive nanogels • Poly(N-vinyl caprolactam) • Chitosan nanogel • Albumin release behavior • Target drug delivery • Semi-IPN nanogels * Morteza Ehsani

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Soft poly(N-vinylcaprolactam) nanogels surface-decorated with AuNPs. Response to temperature, light, and RF-field

Cited by 21 publications

References 62 publications

Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(N-Vinylcaprolactam) Nanogels

Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(N-Vinylcaprolactam) Nanogels

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Magnetic dual-responsive semi-IPN nanogels based on chitosan/PNVCL and study on BSA release behavior

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