Soft corals collected from Jeju Island; a potential source of anti-inflammatory phytochemicals

Wang, Lei; Oh, Jae-Young; Fernando, Ilekuttige Priyan Shanura; Sanjeewa, K. K. Asanka; Kim, Eun-A; Lee, Wonwoo; Jeon, You‐Jin

doi:10.17642/jcc.21.4.4

Cited by 13 publications

(14 citation statements)

References 23 publications

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“…Therefore, NO inhibitors are essential for the prevention of inflammatory diseases. Previous studies have indicated that extract of D. gigantea suppressed NO generation and the expression of iNOS and proinflammatory cytokines in murine macrophage cells (Wang et al 2016). SCDE in this study also significantly reduced the elevated NO level induced by LPS treatment in zebrafish embryos.…”

Section: Discussionsupporting

confidence: 73%

“…Recently, the number of Alcyonacean soft coral populations in the sea of Jeju Island is increasing due to the tropical weather. Recent in vitro studies have demonstrated that extract of Dendronephthya gigantea collected from Jeju Island possesses anti-inflammatory effect (Wang et al 2016). Although such results indicate the potential use of the soft coral D. gigantea extract (SCDE) as anti-inflammatory candidates, no studies have yet reported its effects on toxicity and anti-inflammatory activities in vivo model.…”

Section: Introductionmentioning

confidence: 99%

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Developmental toxicity and anti-inflammatory effect of the soft coral Dendronephthya gigantea collected from Jeju Island in zebrafish model

Lee

2017

Fish Aquatic Sci

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Recent in vitro studies have demonstrated that extract of soft coral Dendronephthya gigantea (SCDE) had strong anti-inflammatory activities. However, the direct effects of SCDE on anti-inflammatory activities in vivo model remained to be determined. Therefore, the present study was designed to assess in vivo anti-inflammatory effect of SCDE using lipopolysaccharide (LPS)-stimulated zebrafish model. We also investigated whether SCDE has toxic effects in zebrafish model. The survival, heart beat rate, and developmental abnormalities were no significant change in the zebrafish embryos exposed to at a concentration below 100 μg/ml of SCDE. However, lethal toxicity was caused after exposure to 200 and 400 μg/ml of SCDE. Treating zebrafish model with LPS treatment significantly increased the reactive oxygen species (ROS) and nitric oxide (NO) generation. However, SCDE inhibited this LPS-stimulated ROS and NO generation in a dose-dependent manner. These results show that SCDE alleviated inflammation by inhibiting the ROS and NO generation induced by LPS treatment. In addition, SCDE has a protective effect against the cell damage induced by LPS exposure in zebrafish embryos. This outcome could explain the profound anti-inflammatory effect of SCDE both in vitro as well as in vivo, suggesting that the SCDE might be a strong anti-inflammatory agent.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Developmental toxicity and anti-inflammatory effect of the soft coral Dendronephthya gigantea collected from Jeju Island in zebrafish model

Lee

2017

Fish Aquatic Sci

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“…Therefore, NO inhibitors are essential for the prevention of inflammatory diseases. Previous studies have indicated that the extract of soft coral D. puetteri collected from Jeju Island suppressed NO generation in murine macrophage cells [ 11 ]. In the present study, we found that DPE also significantly reduced the elevated NO level induced by LPS-treatment in zebrafish embryos.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the number of Alcyonacean soft coral populations in the sea of Jeju Island, Korea’s southernmost island, has been increasing due to tropical weather. Several studies have recently demonstrated that Dendronephthya species collected from Jeju Island display a range of biological activities [ 11 , 12 , 13 ]. Although such results indicate the potential of the soft coral Dendronephthya species as natural bioactive candidates, Dendronephthya puetteri collected from the sea of Jeju Island has not been extensively studied in terms of toxicity and anti-inflammatory activities in an in vivo model.…”

Section: Introductionmentioning

confidence: 99%

Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish

Kim

Ding

Yang

et al. 2018

IJMS

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Marine-derived extract and/or bioactive compounds have attracted increasing demand due to their unique and potential uses as cures for various inflammation-based diseases. Several studies revealed anti-inflammatory candidates found in soft corals. However, the effects of soft corals on inflammation in an in vivo model remain to be determined. Therefore, the extract of soft coral Dendronephthya puetteri (DPE) was investigated for an in vivo anti-inflammatory effect in a lipopolysaccharide (LPS)-stimulated zebrafish model to determine its potential use as a natural anti-inflammatory agent. We also investigated whether DPE has toxic effects in a zebrafish model. No significant changes were observed in terms of survival, heart beat rate, or developmental abnormalities in the zebrafish embryos exposed to a concentration below 100 µg/mL of DPE. Treating the zebrafish model with LPS-treatment significantly increased the ROS, NO generation, and cell death. However, DPE inhibited this LPS-stimulated ROS, NO generation, and cell death in a dose-dependent manner. In addition, DPE significantly reduced the mRNA expression of both iNOS and COX-2 and markedly suppressed the expression levels of the proinflammatory cytokines, TNF-α and IL-6, in an LPS-stimulated zebrafish model. These findings demonstrate that DPE has profound anti-inflammatory effect in vivo, suggesting that DPE might be a strong natural anti-inflammatory agent.

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“…HDF cells were seeded in a 24-well plate and incubated for 24 h. Cells were treated with DPHC (25, 50, and 100 µM) for 1h, and ERM-CZ-100 (200 µg/mL) was added into each well. After 3 h, the intracellular ROS levels of ERM-CZ-100-treated HDF cells were evaluated by DCF-DA assay following the protocol described previously [43,44]. After 24 h, the viabilities of ERM-CZ-100-treated HDF cells were measured by MTT assay according to the methods described previously [45,46].…”

Section: Determination Of the Effect Of Dphc On Pm-induced Cytotoxicimentioning

confidence: 99%

Protective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae Against Particulate Matter-Induced Skin Damage by Regulation of NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

Wang

Kim

et al. 2020

Molecules

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Particulate matters (PM), the main contributor to air pollution, have become a serious issue that threatens human’s health. Skin is the largest organ in humans, as well as the primary organ exposed to PM. Overexposure of PM induces skin damage. Diphlorethohydroxycarmalol (DPHC), an algal polyphenol with the potential of skin protection, has been isolated from the edible brown seaweed Ishige okamurae. The purpose of the present study is to investigate the protective effect of DPHC against PM (ERM-CZ100)-induced skin damage in human dermal fibroblasts (HDF) cells. The results indicated that DPHC significantly and dose-dependently reduced intracellular reactive oxygen species generation in HDF cells. In addition, DPHC significantly induced collagen synthesis and inhibited collagenase activity in ERM-CZ100-stimulated HDF cells. Further study demonstrated that DPHC remarkably reduced the expression of human matrix metalloproteinases through regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases signaling pathways in ERM-CZ100-stimulated HDF cells. This study suggested that DPHC is a potential candidate to protect skins against PM-induced damage, and it could be used as an ingredient in pharmaceutical and cosmeceutical industries.

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Soft corals collected from Jeju Island; a potential source of anti-inflammatory phytochemicals

Cited by 13 publications

References 23 publications

Developmental toxicity and anti-inflammatory effect of the soft coral Dendronephthya gigantea collected from Jeju Island in zebrafish model

Developmental toxicity and anti-inflammatory effect of the soft coral Dendronephthya gigantea collected from Jeju Island in zebrafish model

Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish

Protective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae Against Particulate Matter-Induced Skin Damage by Regulation of NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

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