SODs, DNA binding and cleavage studies of new Mn(III) complexes with 2-((3-(benzyloxy)pyridin-2-ylimino)methyl)phenol

Copper(II) complexes with new fluoroquinolones: Synthesis, structure, spectroscopic and theoretical study, DNA damage, cytotoxicity and antiviral activity

“…Based on the above findings for the system under study we can propose two parallel mechanisms of action: intercalation of phenanthroline moiety into DNA, as well as free radicals production by Fenton/HaberWeiss reactions, forming damaging hydroxyl radicals, as well as superoxide radical anions. These results are consistent with many in vitro studies conducted with copper(II) complexes and DNA that confirmed the DNA binding and cleavage capabilities in the presence of hydrogen peroxide or ascorbic acid [36,38,76,77,80].…”

“…It has been observed that in the presence of metal complexes, the covalently closed circular form of plasmid DNA (SC, supercoiled DNA) can be cleaved to nicked circular (relaxed) form (single strand scission) or to linear form (double strand scission) [76][77][78]. The occurrence of nicked and/or linear conformation states of plasmid DNA, monitored by gel electrophoresis, is commonly considered as a result of the DNAmetal complex interaction.…”

Deep UV dispersion and absorption spectroscopy of biomolecules

“…Calf thymus DNA: DNA extracted from calf thymus is an abundant source of high molecular weight pure DNA to study properties and interactions of DNA. One of the main applications of calf DNA is to study DNA binding anticancer agents [34][35][36].…”

Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

“…Manganese is potential antimicrobial agent with low toxicity and high selectivity than nickel, copper, titanium, zirconium, silver, cadmium and zinc [73]. The antimicrobial activity indicates that the complex is more active than the ligand.…”