Sodium  -Resorcylate in Rheumatic Fever

Reid, James; Watson, R. Douglas; Cochran, Joel B.; Sproull, D. H.

doi:10.1136/bmj.2.4727.321

Cited by 61 publications

(18 citation statements)

References 2 publications

(3 reference statements)

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“…Weight loss, though it can result from treatment with any of these agents and may be associated with a depression in the butanol-extractable iodine of serum (37), appears not to be essential since rats not exhibiting weight loss show similar thyroid depression [ (5) and Table IV], and the salicylate-treated patients described in the previous paper (1) exhibit thyroid inhibition in the absence of weight (40), it is in loss. means of de A theory of action that has been proposed for the literature salicylates is that which emphasizes ortho-phenolic thyroid is e3 substitution and the chelation resulting from in-of cortisone ternal hydrogen bonding (17). Two possible ef-suppress iod fects might be involved: a) replacement of the hy-(50 mg. per drogen by some metal ion required for enzymatic from the gla reactions, and b) stabilization of the carboxylate per day did anion leading to increased acidity, especially in the FurthermorC case of the di-ortho-substituted -y-resorcylate appear to be (38).…”

Section: Commentsmentioning

confidence: 99%

Salicylates and Thyroid Function. II. The Effect on the Thyroid-Pituitary Interrelation

Wolff¹,

Austen²

1958

J. Clin. Invest.

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In the preceding paper (1) it was pointed out that the administration of sodium salicylate to man induces a number of changes suggestive of thyrotoxicosis. There is an elevated basal metabolic rate (BMR), negative nitrogen balance, a fall in the cholesterol level of the hypothyroid subject, and an accelerated fractional disappearance rate of labeled thyroxine from the circulation. Paradoxically, salicylate-induced hypermetabolism is not accompanied by certain of the clinical characteristics of hyperthyroidism and is associated with depressed thyroid function as measured by thyroidal radioiodine uptake and clearance, or the serum protein bound iodine (PBI) concentration. The salicylate level in the serum of such patients is not high enough to interfere with in vitro iodine metabolism in rat thyroid slices, and in acute experiments in rats no depression of the iodide concentrating mechanism can be demonstrated at blood salicylate levels comparable to those attained in the above patients (1). Similar findings had previously been recorded in rats and in man treated with 2,4-dinitrophenol (2-4). It was subsequently shown (5) that this thyroid depression produced by 2,4-dinitrophenol probably resulted from inhibition at a pituitary or higher level.The absence of a direct or immediate effect of salicylates on thyroid tissue, despite marked thyroid depression upon more prolonged exposure to the drug, suggested that this effect may also result from a decrease in thyroid stimulation by thyrotropin (TSH). It is the purpose of this report to suggest a locus of salicylate action and to present some observations on the nature of the inhibitory effect. MATERIALS AND METHODSThree euthyroid patients were studied to evaluate the effect of salicylates on the rate of release of radioiodine from the thyroid gland. The technique was similar to that described by Goldsmith, Stanbury, and Brownell (6). Each patient, while fasting, was given approximately 125 microcuries of radioiodine, and 48 hours later was started on 1-methyl-2-mercaptoimidazole, 30 mg. every six hours, to block the reaccumulation of radioiodine. Counts over the thyroid region were measured each morning with a wide angle scintillation counter. Body background was taken as the thigh count, and the logarithm of the counts remaining in the thyroid after correction for body background and physical decay was plotted against time to determine half-life and rate of release of thyroidal I'.

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Section: Commentsmentioning

confidence: 99%

Salicylates and Thyroid Function. II. The Effect on the Thyroid-Pituitary Interrelation

Wolff¹,

Austen²

1958

J. Clin. Invest.

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“…Cochran, et al (126), found y-resorcylic acid (XX) to be nearly ten times as effective as salicylic acid in relieving rheumatic fever patients. This increased effect was attributed to a greater degree of chelation by the resorcylic acid but no stability constants were listed.…”

Section: Salicylatesmentioning

confidence: 97%

Role of Metal-Binding in the Biological Activities of Drugs

Foye

1961

Journal of Pharmaceutical Sciences

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“…Sporadic reports were published on clinical trials with 2,3-dihydroxybenzoic acid (pyrocatechic acid) and 2,6-dihydroxybenzoic acid (gamma-resorcylic acid) particularly in regard to the treat ment of rheumatic fever [11,3]. Only pyrocatechic acid (Movirene®) and to a certain extent 2,5-dihydroxybenzoic acid (gentisic acid) remained for practical use [8).…”

Section: Effect O F M Ono-an D D Ihydroxybenzoic a Cidsmentioning

confidence: 99%