DOI: 10.2147/jir.s303105
View full text
Dan Chen, Zhi-qi Gao, Ying-ying Wang, Bin-bin Wan, Gang Liu, Jun-liang Chen, Ya-xian Wu, Qin Zhou, Shan-yu Jiang, Ren-qiang Yu, Qing-feng Pang

Abstract: Background Alveolar arrest and the impaired angiogenesis caused by chronic inflammation and oxidative stress are two main factors in bronchopulmonary dysplasia (BPD). Short-chain fatty acids (SCFAs), especially propionate, possess anti-oxidant and anti-inflammatory effects. The present study was designed to examine the roles of sodium propionate (SP) on lipopolysaccharide (LPS)-challenged BPD and its potential mechanisms. Methods WT, Nrf2 -/- …

expand abstract