Health Benefits and Side Effects of Short-Chain Fatty Acids

Xiong, Ruo-Gu; Zhou, Dan-Dan; Wu, Si-Xia; Huang, Siyu; Saimaiti, Adila; Yang, Zhijun; Shang, Ao; Zhao, Cong; Gan, Ren‐You; Li, Hua Bin

doi:10.3390/foods11182863

Cited by 125 publications

(73 citation statements)

References 121 publications

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“…Although BBR exhibited potential anti-BC activity in preclinical studies, there are several predicaments to overcome before it was been advanced into clinical treatment against BC. Firstly, several studies showed that BBR exhibited low toxicity to healthy cells and human beings (126,127). It could also lead to some adverse events, such as constipation and nausea (128,129).…”

Section: Discussionmentioning

confidence: 99%

Berberine as a potential agent for breast cancer therapy

Zhong

Chen

et al. 2022

Front. Oncol.

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Breast cancer (BC) is a common malignancy that mainly occurred in women and it has become the most diagnosed cancer annually since 2020. Berberine (BBR), an alkaloid extracted from the Berberidacea family, has been found with broad pharmacological bioactivities including anti-inflammatory, anti-diabetic, anti-hypertensive, anti-obesity, antidepressant, and anticancer effects. Mounting evidence shows that BBR is a safe and effective agent with good anticancer activity against BC. However, its detailed underlying mechanism in BC treatment remains unclear. Here, we will provide the evidence for BBR in BC therapy and summarize its potential mechanisms. This review briefly introduces the source, metabolism, and biological function of BBR and emphasizes the therapeutic effects of BBR against BC via directly interacting with effector proteins, transcriptional regulatory elements, miRNA, and several BBR-mediated signaling pathways. Moreover, the novel BBR-based therapeutic strategies against BC improve biocompatibility and water solubility, and the efficacies of BBR are also briefly discussed. Finally, the status of BBR in BC treatment and future research directions is also prospected.

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Section: Discussionmentioning

confidence: 99%

Berberine as a potential agent for breast cancer therapy

Zhong

Chen

et al. 2022

Front. Oncol.

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“…High-fiber diets are beneficial and reduce the risk of obesity, diabetes, hypertension, and cardiovascular disease (CVD), which are common comorbidities of RA [ 15 , 16 , 56 ]. In patients with RA, approx.…”

Section: Discussionmentioning

confidence: 99%

“…Reported fiber intakes were not higher in other studies for people with RA or in the general German population [ 38 , 59 , 60 ]. Dietary fiber supplementation has a potential to close this fiber gap [ 56 ]. Interestingly, none of the patients used a dietary fiber supplement or asked for information on high-fiber food sources.…”

Section: Discussionmentioning

confidence: 99%

Nutrition Patterns and Their Gender Differences among Rheumatoid Arthritis Patients: A Descriptive Study

et al. 2022

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Dietary factors probably play a role in the pathogenesis and clinical course of rheumatoid arthritis (RA). There is a paucity of specific dietary guidelines for RA patients and little information on their implementation in daily life. Therefore, this study aimed to determine the nutritional status and provision of nutritional education among outpatients with RA. Here, 61 patients were included with a sex ratio of 2.03 (f/m). Based on BMI, 22% of women were overweight and 32% obese, whereas 50% of men were overweight and 30% obese. Fasting blood and a 3-day estimated dietary record were collected. Additionally, patients were asked whether they had already received information about a specific diet as part of their disease treatment plan. Elevated total cholesterol levels were found in 76% of women and in 60% of men caused by increased non-HDL-C levels. The dietary intake assessment showed a lower self-reported intake of energy, polyunsaturated fat, carbohydrates, fiber, and several micronutrients than recommended. Regarding healthy eating, all patients reported familiarity with dietary recommendations, but found it difficult to implement the recommendations into their diets. These findings suggested that RA patients need more specific recommendations and education in clinical practice to improve the quality of their diet.

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“…Therefore, the net effects of the actions of SCFAs are context-dependent and can be pro- or anti-inflammatory ( Schilf et al, 2021 ). The exact effects of SCFAs may depend on the type of SCFAs, the delivery method, the levels and the health condition of hosts ( Xiong et al, 2022 ). Moreover, fermentation initiators such as sucrose can selectively promote SCFA production by the probiotic S. epidermidis , and improve acne dysbiosis ( Wang et al, 2016 ).…”

Section: Scfa-based Therapy For Inflammatory Skin Diseasesmentioning

confidence: 99%

The role of short-chain fatty acids in inflammatory skin diseases

Xiao

Yao

et al. 2023

Front. Microbiol.

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Short-chain fatty acids (SCFAs) are metabolites of gut microbes that can modulate the host inflammatory response, and contribute to health and homeostasis. Since the introduction of the gut-skin axis concept, the link between SCFAs and inflammatory skin diseases has attracted considerable attention. In this review, we have summarized the literature on the role of SCFAs in skin inflammation, and the correlation between SCFAs and inflammatory skin diseases, especially atopic dermatitis, urticaria, and psoriasis. Studies show that SCFAs are signaling factors in the gut-skin axis and can alleviate skin inflammation. The information presented in this review provides new insights into the molecular mechanisms driving gut-skin axis regulation, along with possible pathways that can be targeted for the treatment and prevention of inflammatory skin diseases.

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Health Benefits and Side Effects of Short-Chain Fatty Acids

Cited by 125 publications

References 121 publications

Berberine as a potential agent for breast cancer therapy

Berberine as a potential agent for breast cancer therapy

Nutrition Patterns and Their Gender Differences among Rheumatoid Arthritis Patients: A Descriptive Study

The role of short-chain fatty acids in inflammatory skin diseases

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