Sodium fluoride and casein phosphopeptide-amorphous calcium phosphate cream plus sodium fluoride efficacy in preventing enamel erosion in a simulated oral environment study model

Amaral, Cristiane Mariote; Miranda, Maria Maria Elisa da Silva Ng; Correa, D.S.; Silva, Eduardo M.

doi:10.4103/0970-9290.142536

Cited by 5 publications

(8 citation statements)

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“…The use of toothpaste would be the preferred mode of topical availability of CPP-ACP, as toothpastes are routinely used in oral hygiene. Accordingly, the use of MI Paste as a toothpaste in the present study is justified 21 . Studies by Wegehaupt & Attin 13 , Rallan 14 and Carvalho 11 which found similar results to our study, used the provision of CPP-ACP through the use of toothpaste, unlike the studies by Iijima 7 , Cai et al 15 , Prestes 16 and Alencar 17 in which the CPP-ACP was released on to the enamel with the use of chewing gum, which may explain the difference found in the results.…”

Section: Discussionmentioning

confidence: 95%

“…Several authors have shown that different lengths of exposure for acidic beverages result in very different estimates of erosive potential and that the choice of study methodology can affect the results of the study 21 . In the study by Carvalho 11 the erosive challenge was conducted for five minutes, four times a day for 5 days, similar to the present study, and both produced the same result.…”

Section: Discussionmentioning

confidence: 99%

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Effect of CPP-ACP on enamel eroded extrinsically: in vitro study

Scardini

Dias

Castro

et al. 2018

RGO, Rev. Gaúch. Odontol.

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Objective: The aim of this study was to evaluate the remineralization effect of CPP-ACP on tooth enamel that is eroded extrinsically. Methods: Sixty freshly extracted bovine teeth were stored in a solution of thymol (0.1%), cut into enamel blocks (6x6mm), abraded with silicon carbide sandpaper (600, 800 and 1200 grit) and polished with felt. The specimens were randomly divided into 4 groups (n=15), varying the immersion medium , deionized water or citric acid, and the optional use of CPP-ACP. (G1: deionized water; G2: citric acid; G3: deionized water + CPP-ACP; G4: citric acid + CPP-ACP). The samples were subjected to 4 cycles of erosion every day, comprising 5 minutes immersion in one medium and 2 hours of immersion in artificial saliva, for 5 consecutive days. After each erosive cycle, 20 uL of the MI Paste was applied for 5 minutes on one half of the samples and washed with deionized water. Before and after the erosive cycling, the measurements of Vickers hardness and surface roughness were taken. Results: The results were evaluated through statistical testing. The final hardness and roughness values showed no statistically significant difference between G2 and G4. The paste in G4 did not promote an increase in hardness values nor a decrease in roughness values. Conclusion: It was concluded that CPP-ACP was unable to remineralize enamel subjected to extrinsic erosion, being ineffective in preventing erosion of enamel and in the remineralization of the eroded enamel.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Effect of CPP-ACP on enamel eroded extrinsically: in vitro study

Scardini

Dias

Castro

et al. 2018

RGO, Rev. Gaúch. Odontol.

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“…Os fosfopeptídeos de caseína (CPP) contêm a sequência de peptídeos -Ser (P) -Ser (P) -Ser (P) -Glu -Glu -que possuem capacidade para estabilizar fosfato de cálcio amorfo (ACP) em solução metaestável sobressaturada 13,34,35 . Assim sendo, o CPP-ACP atua como uma fonte suplementar de cálcio e fosfato biodisponíveis no ambiente bucal 17 , sendo proposto tanto por inibir a perda de minerais 3,5 , como para intensificar sua deposição em lesões desmineralizadas do esmalte dentário, à exemplo das lesões erosivas 30 19,25,27,[43][44][45][46] . No que diz respeito aos seus mecanismos de controle da erosão dentária, o CPP-ACP pode atuar tanto na precipitação mineral 17,39 , como na redução da desmineralização da estrutura dentária 36,39 .…”

Section: Resultados O Erosãounclassified

“…Vários estudos avaliaram o poder preventivo das pastas de CPP-ACP aplicadas no esmalte previamente ao desafio erosivo, associadas ou não ao fluoreto, comparadas a diversos outros agentes protetores, utilizando protocolos de estudo distintos e enquanto alguns 3,5,40 obtiveram resultados positivos, outros 25,27,42,44,[47][48][49][50] encontraram resultados pouco favoráveis.…”

Section: Resultados O Erosãounclassified

Utilização de pastas contendo fosfopeptídeo de caseína-fosfato de cálcio amorfo com e sem fluoreto na prevenção da erosão dentária: uma revisão da literatura

Fernandes¹,

Moura²,

Alencar³

et al. 2017

Arch Health Invest

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ResumoIntrodução: A erosão dentária caracteriza-se como uma perda progressiva de estrutura dentária em que ocorre dissolução localizada de minerais da superfície do dente, ocasionada devido a exposição a ácidos de origem não bacteriana. Esse agravo bucal tem ganhado destaque pelo aumento de sua prevalência, que tem ocorrido, principalmente, devido a mudança dos hábitos alimentares e no estilo de vida da sociedade moderna. Objetivo: Apresentar uma síntese da ação das pastas de CPP-ACP no controle da erosão dentária. Material e Método: Foi realizada uma revisão da literatura nas bases de dados eletrônicas: Pubmed, Scopus e Bireme, utilizando os termos Erosão Dentária, Tooth Erosion, Esmalte Dentário, Dental Enamel, Caseínas, Caseins, Fluoreto de Sódio, Sodium Fluoride e os operadores boleanos "AND" e "OR" para realização das buscas, não havendo restrição quanto ao ano ou idioma de publicação. Resultados: Diferentes condutas terapêuticas têm sido avaliadas como potenciais alternativas para o controle da erosão dentária, dentre os quais está o uso da caseína fosfopeptídeo -fosfato de cálcio amorfo (CPP-ACP). As pastas de CPP-ACP parecem ser o tipo de veículo com maior potencial preventivo, além disso, a literatura sugere também, que as abordagens adotadas previamente às exposições ácidas tendem a ser mais bem-sucedidas. Apesar disso, ainda não há um consenso sobre a eficácia desse recurso terapêutico, devido, principalmente a carência de estudos realizados sob protocolos in situ. Conclusão: A ação preventiva das pastas de CPP-ACP, suplementadas ou não pelo fluoreto, permanece incipiente na literatura. Descritores: Erosão Dentária; Esmalte Dentário; Caseínas; Fluoreto de Sódio. AbstractIntroduction: Dental erosion is characterized as a progressive loss of tooth structure in which localized dissolution of minerals from the tooth surface occurs due to exposure to acids of non-bacterial origin. This oral grievance has been highlighted by the increase in its prevalence, which has mainly occurred due to changes in eating habits and in the lifestyle of modern society. Objective: To present a synthesis of the action of CPP-ACP pulps in the control of dental erosion. Material and Methods: A literature review was carried out in the electronic databases: Pubmed, Scopus e Bireme, using the terms Erosion, Tooth Erosion, Dental Enamel, Dental Enamel, Caseins, Caseins, Sodium Fluoride, Sodium Fluoride and the Boolean operators "AND" and "OR" to carry out the searches, without restriction regarding the year or language of publication. Results: Different therapeutic approaches were evaluated as possible alternatives for the control of dental erosion, among them the use of phosphine casein -amorphous calcium phosphate (CPP-ACP). CPP-ACP pulps seem to be the type of vehicle with the greatest preventive potential, and the literature also suggests that approaches adopted prior to acid exposures tend to be more successful. Despite this, there is still no consensus on the efficacy of this therapeutic resource, due mainly to the lack of st...

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“…The key of remineralization or regeneration of tooth hard tissue is finding an appropriate organic template and inducing the process of mineralization. The frequently used agents are fluoride [3], salivary proteins [4], casein phosphopeptide amorphous calcium phosphate [5], or organic polymers [6]. However, these approaches either call for too severe conditions to apply in clinics, or reconstruct structures unlike natural enamel.…”

Section: Introductionmentioning

confidence: 99%

Constructed amphiphilic gel as natural auxiliary medium to mimick remineralized dental hydroxyapatite

Tian¹,

Liu²,

Xu³

et al. 2016

Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics

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For obtain enamel-like hydroxyapatite, we are trying to induce the growth of crystal with modified chitosan which can simulate the organic template like extracellular matrix--Amelogenin to induce the deposition of miner ions. Phosphorous acid modification was applying into natural polycation polysaccharide chitosan to synthesize polyanion derivate phosphorylated chitosan. Amphiphilic hydrogels combined with phosphorylated chitosan (+cation) and gelatin (-anion) were built through peptide binding reaction which using Genipin as crosslinker. The gels self assembled on the inert surface of tooth which stimulated by ultraviolet radiation. CaCl 2 and Na 3 PO 4 -12H 2 O solutions provided mineralized ion then the hydroxyapatite assembled and grown in situ of the tooth. All of the samples detected by FTIR, SEM and XRD to confirm the character of neonatal crystal. The amphiphilic gel can enhance the proportion of organic elements on the surface of dentin which confirmed by FTIR. After mineralized reaction, we observed bunch and column (15-25nm) crystal arranged on the dentin base. XRD result showed the neonatal crystal is hydroxyapatite and scratch tester testified the coalescent force between 22-25N. The amphiphilic gel can be induced the enamel-like crystal grown under demineralizing tooth basement.

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Sodium fluoride and casein phosphopeptide-amorphous calcium phosphate cream plus sodium fluoride efficacy in preventing enamel erosion in a simulated oral environment study model

Abstract: It was concluded that tooth brushing with dentifrices with high concentration of NaF and CPP-ACPF cream was not able to prevent enamel erosion in simulated oral environment.

Cited by 5 publications

References 0 publications

Effect of CPP-ACP on enamel eroded extrinsically: in vitro study

Effect of CPP-ACP on enamel eroded extrinsically: in vitro study

Utilização de pastas contendo fosfopeptídeo de caseína-fosfato de cálcio amorfo com e sem fluoreto na prevenção da erosão dentária: uma revisão da literatura

Constructed amphiphilic gel as natural auxiliary medium to mimick remineralized dental hydroxyapatite

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